Zobrazeno 1 - 10
of 294
pro vyhledávání: '"Orme, A"'
Autor:
Mark W. Orme, Susan Hayes Henry, Michael J Reid, Ryo Kubota, Kuo Lee Lieu, Christine Diamond, Niklas Tulberg
Publikováno v:
Mediators of Inflammation
Mediators of Inflammation, Vol 2020 (2020)
Mediators of Inflammation, Vol 2020 (2020)
Vascular adhesion protein-1 (VAP-1) is an ectoenzyme that functions as a copper-containing amine oxidase and is involved in leukocyte adhesion at sites of inflammation. Inhibition of VAP-1 oxidative deamination has become an attractive target for ant
Autor:
Haojie Huang, Ting Wei, Martin E. Gleave, Ladan Fazli, Lei Shi, Yuzhuo Wang, R. Jeffrey Karnes, Jacob J. Orme, Yundong He, Haoyue Sheng, Zhenqing Ye, Rafael E. Jimenez, Liguo Wang, Liewei Wang, Dong Lin
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Nature Communications
Nature Communications
Resistance to next-generation anti-androgen enzalutamide (ENZ) constitutes a major challenge for the treatment of castration-resistant prostate cancer (CRPC). By performing genome-wide ChIP-seq profiling in ENZ-resistant CRPC cells we identify a set
Autor:
Daniel Wendt, Gregory L. Mines, Aaron D. Wilson, Christopher J. Orme, Michael G. Jones, Birendra Adhikari
Publikováno v:
Journal of Membrane Science. 583:258-266
Different methods of introducing CO2 to a heterogeneous mixture of water and 1-cyclohexylpiperidine are explored in order to generate a single-phase aqueous 1-cyclohexylpiperidinium bicarbonate solution. Membrane gas contacting was found to be an eff
Autor:
Verity Talbot, Nancy Dekki, Joseph Shaw, Michal Bista, Michael Dabrowski, Lindsey Leach, Martin J. Main, Davide Gianni, Ian L. Dale, Ana J. Narvaez, Paul Hemsley, Jonathan P. Orme, Daniel Martinez Molina
Publikováno v:
Slas Discovery
Methods to measure cellular target engagement are increasingly being used in early drug discovery. The Cellular Thermal Shift Assay (CETSA) is one such method. CETSA can investigate target engagement by measuring changes in protein thermal stability
Autor:
Joshua Garlich, Mathieu Cinier, Anne Chevrel, Anaëlle Perrocheau, David J. Eyerman, Mark Orme, Olivier Kitten, Lukas Scheibler
Publikováno v:
Biomolecules; Volume 12; Issue 3; Pages: 432
Uncontrolled complement activation contributes to multiple immune pathologies. Although synthetic compstatin derivatives targeting C3 and C3b are robust inhibitors of complement activation, their physicochemical and molecular properties may limit acc
Autor:
Coles, Christopher J., Holm, Richard H., Kurtz, Donald M., Orme-Johnson, William H., Rawlings, Jill, Singer, Thomas P., Wong, Geoffrey B.
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 1979 Aug 01. 76(8), 3805-3808.
Externí odkaz:
https://www.jstor.org/stable/69714
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 1975 Dec 01. 72(12), 4795-4799.
Externí odkaz:
https://www.jstor.org/stable/65290
Autor:
Reeve, John N., Beckler, Gregory S., Cram, David S., Hamilton, Paul T., Brown, James W., Krzycki, Joseph A., Kolodziej, Andrew F., Alex, Lisa, Orme-Johnson, William H., Walsh, Christopher T.
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 1989 May 01. 86(9), 3031-3035.
Externí odkaz:
https://www.jstor.org/stable/33794
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 1983 Jan 01. 80(1), 147-150.
Externí odkaz:
https://www.jstor.org/stable/13338
Autor:
Kojima, Nakao, Fox, Judith A., Hausinger, Robert P., Daniels, Lacy, Orme-Johnson, William H., Walsh, Christopher
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 1983 Jan . 80(2), 378-382.
Externí odkaz:
https://www.jstor.org/stable/13611