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pro vyhledávání: '"Michelle Kelleher"'
Autor:
Douglas L. Tolson, Emanuela Handman, Antony Bacic, Terry W. Pearson, Malcolm J. McConville, Martin J Elhay, Michelle Kelleher
Publikováno v:
Molecular and Biochemical Parasitology. 40:255-267
Lipophosphoglycan (LPG) of Leishmania is a polymorphic molecule comprising an alkylglycerol anchor, a conserved oligosaccharide core and a species-specific polymer of oligosaccharide repeats joined by phosphodiester bonds. This molecule, together wit
Autor:
P Mirabile, Michelle Kelleher, Amelia H. Osborn, Antony Bacic, Emanuela Handman, Susan F. Moody
Publikováno v:
Infection and immunity. 63(1)
Promastigotes of the intracellular protozoan parasite Leishmania major invade mononuclear phagocytes by a direct interaction between the cell surface lipophosphoglycan found on all Leishmania species and macrophage receptors. This interaction is medi
Publikováno v:
Molecular and biochemical parasitology. 66(2)
Monoclonal antibodies (MAbs) were generated against Leishmania major promastigote lipophosphoglycan (LPG) to use as tools in defining functional epitopes of this major cell surface glycoconjugate. Epitope mapping of four MAbs, designated 4A2-A2, 2G11
Publikováno v:
Analytical biochemistry. 217(2)
Rabbits were immunized with glycolipid and membrane glycoprotein extracts of the promastigotes of Leishmania major partially purified by two-phase extraction with Triton X-114. The resulting antibodies were affinity purified on agarose immunoadsorben
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 89(1)
Leishmania are obligatory intracellular parasites in mammalian macrophages that gain entry by receptor-mediated phagocytosis. Their major cell surface glycoconjugate, lipophosphoglycan (LPG), has been implicated in this process. A monoclonal antibody