Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Michael J. Kruhlak"'
Publikováno v:
Biochemical and Biophysical Research Communications. 663:171-178
Autor:
Naritaka Tamaoki, Stefan Siebert, Takuya Maeda, Ngoc-Han Ha, Meghan L. Good, Yin Huang, Suman K. Vodnala, Juan J. Haro-Mora, Naoya Uchida, John F. Tisdale, Colin L. Sweeney, Uimook Choi, Julie Brault, Sherry Koontz, Harry L. Malech, Yasuhiro Yamazaki, Risa Isonaka, David S. Goldstein, Masaki Kimura, Takanori Takebe, Jizhong Zou, David F. Stroncek, Pamela G. Robey, Michael J. Kruhlak, Nicholas P. Restifo, Raul Vizcardo
Publikováno v:
Cell Reports Methods. 3:100460
Autor:
Gareth N. Corry, Juan Ausió, Darin McDonald, Hilmar Strickfaden, John Th'ng, Michèle Rouleau, Guy G. Poirier, Toyotaka Ishibashi, Jean-François Haince, Michael J. Kruhlak, D. Alan Underhill, Michael J. Hendzel
Publikováno v:
Journal of Biological Chemistry. 291:1789-1802
Chromatin undergoes a rapid ATP-dependent, ATM and H2AX-independent decondensation when DNA damage is introduced by laser microirradiation. Although the detailed mechanism of this decondensation remains to be determined, the kinetics of decondensatio
Autor:
David F. Stroncek, Takuya Maeda, Nicholas P. Restifo, Devikala Gurusamy, Zhiya Yu, Rafiqul Islam, Svetlana Pack, Amanda N Hennings, Li Jia, Marta Bosch-Marce, Francis A. Flomerfelt, Raul Vizcardo, Nicholas D. Klemen, Michael J. Kruhlak, Meghan L. Good, Naritaka Tamaoki
Publikováno v:
Blood. 132:3707-3707
T cells are potentially curative for patients with metastatic cancer, but many patients with cancer have T cells that are 'terminally differentiated', a condition associated with treatment failure. We have observed that less differentiated T cells ha
Publikováno v:
Journal of Biological Chemistry. 287:40328-40338
IL-15 can either be transpresented by IL-15Rα or be secreted.New N- and C-terminal splice versions of human IL-15Rα determine whether IL-15 is secreted or stays bound to the cell membrane.IL-15Rα isoforms determine the mode of action of IL-15.IL-1
Autor:
Susan O. Sharrow, Larry Granger, Tullia Lindsten, Craig B. Thompson, François Van Laethem, Xuguang Tai, Terry I. Guinter, Anthony J. Adams, Lionel Feigenbaum, Alfred Singer, Leonid A. Pobezinsky, Michael J. Kruhlak
Publikováno v:
Blood. 119:5155-5163
CTLA-4 proteins contribute to the suppressor function of regulatory T cells (Tregs), but the mechanism by which they do so remains incompletely understood. In the present study, we assessed CTLA-4 protein function in both Tregs and conventional (Tcon
Autor:
Manuela Fahrleitner, Bernhard Nieswandt, Sabine Ring, Sven G. Meuth, Stephan Gnerlich, Alexander Enk, Stefan W. Schneider, Björn F. Krämer, Tanja Schönberger, Michael J. Kruhlak, Meinrad Gawaz, Sarah Gehring, Harald F. Langer, Anke S. Lonsdorf
Publikováno v:
Journal of Biological Chemistry. 287:2168-2178
A mutual relationship exists between metastasizing tumor cells and components of the coagulation cascade. The exact mechanisms as to how platelets influence blood-borne metastasis, however, remain poorly understood. Here, we used murine B16 melanoma
Autor:
Ruchika Nijhara, Stanley L. Erlandsen, Martin J. Brown, Stephen Shaw, John A. Hallam, Jérôme Delon, Kenneth M. Yamada, Michelle Gignac, Michael J. Kruhlak
Publikováno v:
Blood. 102:3890-3899
Lymphocyte microvilli mediate initial rolling-adhesion along endothelium but are lost during transmigration from circulation to tissue. However, the mechanism for resorption of lymphocyte microvilli remains unexplored. We show that chemokine stimulat
Autor:
David P. Bazett-Jones, Michael J. Hendzel, Melody A Lever, Natalie A.B MacLean, Michael J. Kruhlak, F.-Michel Boisvert
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 76:9-21
The cell nucleus is increasingly recognized as a spatially organized structure. In this review, the nature and controversies associated with nuclear compartmentalization are discussed. The relationship between nuclear structure and organization of pr
Autor:
Jiong Wu, Nicholas Bertos, Marko Vezmar, David P. Bazett-Jones, Xiang-Jiao Yang, Barry I. Posner, Audrey H. Wang, Michael J. Kruhlak
Publikováno v:
Molecular and Cellular Biology. 20:6904-6912
Histone (de)acetylation is important for the regulation of fundamental biological processes such as gene expression and DNA recombination. Distinct classes of histone deacetylases (HDACs) have been identified, but how they are regulated in vivo remai