Zobrazeno 1 - 10
of 101
pro vyhledávání: '"Markku, Laakso"'
Autor:
Daniel Seung Kim, Anne U. Jackson, Yatong K. Li, Heather M. Stringham, Johanna Kuusisto, Antti J. Kangas, Pasi Soininen, Mika Ala-Korpela, Charles F. Burant, Veikko Salomaa, Michael Boehnke, Markku Laakso, Elizabeth K. Speliotes
Publikováno v:
Journal of Lipid Research, Vol 58, Iss 7, Pp 1471-1481 (2017)
A glutamate-to-lysine variant (rs58542926-T) in transmembrane 6 superfamily member 2 (TM6SF2) is associated with increased fatty liver disease and diabetes in conjunction with decreased cardiovascular disease risk. To identify mediators of the effect
Externí odkaz:
https://doaj.org/article/c308243251f34f96be79794a109cc4c0
The Metabolic Syndrome in Men study: a resource for studies of metabolic and cardiovascular diseases
Autor:
Markku Laakso, Johanna Kuusisto, Alena Stančáková, Teemu Kuulasmaa, Päivi Pajukanta, Aldons J. Lusis, Francis S. Collins, Karen L. Mohlke, Michael Boehnke
Publikováno v:
Journal of Lipid Research, Vol 58, Iss 3, Pp 481-493 (2017)
The Metabolic Syndrome in Men (METSIM) study is a population-based study including 10,197 Finnish men examined in 2005–2010. The aim of the study is to investigate nongenetic and genetic factors associated with the risk of T2D and CVD, and with car
Externí odkaz:
https://doaj.org/article/396d141b88884132a623928f4cb25f9b
Autor:
Lilian Fernandes Silva, Jagadish Vangipurapu, Anniina Oravilahti, Ville Männistö, Markku Laakso
Publikováno v:
Metabolites
Volume 13
Issue 2
Pages: 267
Volume 13
Issue 2
Pages: 267
Both genetic and non-genetic factors are important in the pathophysiology of non-alcoholic fatty liver disease (NAFLD). The aim of our study was to identify novel metabolites and pathways associated with NAFLD by including both genetic and non-geneti
Autor:
Lilian Fernandes Silva, Rowmika Ravi, Jagadish Vangipurapu, Anniina Oravilahti, Markku Laakso
Publikováno v:
Metabolites; Volume 12; Issue 12; Pages: 1159
Organic-anion-transporting polypeptide 1B1 (OATP1B1), encoded by the solute carrier organic anion transporter family member 1B1 gene (SLCO1B1), is highly expressed in the liver and transports several endogenous metabolites into the liver, including s
Autor:
Teemu Kuulasmaa, Markku Laakso, Raimo Jauhiainen, Johanna Kuusisto, Annamaria Laakso, Jagadish Vangipurapu
Publikováno v:
The Journal of Clinical Endocrinology and Metabolism
Background and Aims To investigate the significance of 9 amino acids as risk factors for incident cardiovascular disease events in 9584 Finnish men. Materials and Methods A total of 9584 men (age 57.4 ± 7.0 years, body mass index 27.2 ± 4.2 kg/m2)
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism
J Clin Endocrinol Metab
J Clin Endocrinol Metab
Objective To investigate the metabolite signature of albuminuria in individuals without diabetes or chronic kidney disease to identify possible mechanisms that result in increased albuminuria and elevated risk of type 2 diabetes (T2D). Research Desig
Autor:
William S. Harris, Jason H Y Wu, Matti Uusitupa, Barbara McKnight, Tomi-Pekka Tuomainen, Amanda M. Fretts, Qi Sun, Julie K. Bassett, Allison M. Hodge, Fumiaki Imamura, Rozenn N. Lemaitre, David S. Siscovick, Hung-Ju Lin, Nona Sotoodehnia, Michael Y. Tsai, Lynne E. Wagenknecht, Kalina Rajaobelina, Kuo-Liong Chien, Sabita S. Soedamah-Muthu, Renata Micha, Liana C Del Gobbo, Rachel A. Murphy, Markku Laakso, Dariush Mozaffarian, Albert Koulman, Nita G. Forouhi, Ulf Risérus, Graham G. Giles, Janette de Goede, Andres V Ardisson Korat, Nathan L. Tintle, Nicholas J. Wareham, Waqas Qureshi, Johanna M. Geleijnse, Maria Lankinen, Mackenzie K Senn, Cécilia Samieri, Lars Lind, Wei-Sin Yang, Yun-yu Chen, Frank B. Hu, Matti Marklund, Jyrki K. Virtanen, Alexis C. Wood, Vilmundur Gudnason, Tzu-An Chen, Chaoyu Yu, Luc Djoussé, Jennifer G. Robinson, Catherine Helmer, Kerry L. M. Wong, Ingeborg A. Brouwer
Publikováno v:
PLOS Medicine, 17(6). Nature Publishing Group
PLoS Medicine
PLOS Medicine 17 (2020) 6
PLoS Medicine, Public Library of Science, 2020, 17 (6), pp.e1003102. ⟨10.1371/journal.pmed.1003102⟩
PLoS Medicine, 17(6):e1003102, 1-17. Nature Publishing Group
PLOS Medicine, 17(6)
PLoS Medicine, Vol 17, Iss 6, p e1003102 (2020)
InterAct Consortium 2020, ' Fatty acids in the de novo lipogenesis pathway and incidence of type 2 diabetes : A pooled analysis of prospective cohort studies ', PLoS Medicine, vol. 17, no. 6, e1003102, pp. 1-17 . https://doi.org/10.1371/journal.pmed.1003102
PLoS Medicine
PLOS Medicine 17 (2020) 6
PLoS Medicine, Public Library of Science, 2020, 17 (6), pp.e1003102. ⟨10.1371/journal.pmed.1003102⟩
PLoS Medicine, 17(6):e1003102, 1-17. Nature Publishing Group
PLOS Medicine, 17(6)
PLoS Medicine, Vol 17, Iss 6, p e1003102 (2020)
InterAct Consortium 2020, ' Fatty acids in the de novo lipogenesis pathway and incidence of type 2 diabetes : A pooled analysis of prospective cohort studies ', PLoS Medicine, vol. 17, no. 6, e1003102, pp. 1-17 . https://doi.org/10.1371/journal.pmed.1003102
Background De novo lipogenesis (DNL) is the primary metabolic pathway synthesizing fatty acids from carbohydrates, protein, or alcohol. Our aim was to examine associations of in vivo levels of selected fatty acids (16:0, 16:1n7, 18:0, 18:1n9) in DNL
Autor:
Helena Gylling, Maarit Hallikainen, Jussi Pihlajamäki, Piia Simonen, Johanna Kuusisto, Markku Laakso, Tatu A. Miettinen
Publikováno v:
Journal of Lipid Research, Vol 51, Iss 8, Pp 2422-2427 (2010)
Cholesterol synthesis is upregulated and absorption downregulated in insulin resistance and in type 2 dia-betes. We investigated whether alterations in cholesterol metabolism are observed across the glucose tolerance status, from normoglycemia throug
Externí odkaz:
https://doaj.org/article/6b0fb7c9f0cd4a068421379913d30110
Sex‐Specific Genetic Regulation of Adipose Mitochondria and Their Relationship to Metabolic Syndrome
Autor:
Rebeca Acín-Pérez, Karthickeyan Chella Krishnan, Karen Reue, Aldons J. Lusis, Markku Laakso, Linsey Stiles, Lijiang Ma, Johan L.M. Björkegren, Laurent Vergnes
Publikováno v:
The FASEB Journal. 35
Autor:
Helena Gylling, Maarit Hallikainen, Jussi Pihlajamäki, Jyrki Ågren, Markku Laakso, Radhakrishnan A. Rajaratnam, Rainer Rauramaa, Tatu A. Miettinen
Publikováno v:
Journal of Lipid Research, Vol 45, Iss 9, Pp 1660-1665 (2004)
The roles of polymorphisms of the sitosterolemia genes ABCG5 and ABCG8 in the regulation of cholesterol metabolism and insulin sensitivity were studied in mildly hypercholesterolemic noncoronary subjects (n = 263, 144 men and 119 women) divided into
Externí odkaz:
https://doaj.org/article/525ed55ca4174866bcee6412f86c657f