Zobrazeno 1 - 10
of 72
pro vyhledávání: '"Margery A. Connelly"'
Autor:
Hannah L.M. Steffen, Josephine L.C. Anderson, Margot L. Poot, Yu Lei, Margery A. Connelly, Stephan J.L. Bakker, Katariina Öörni, Uwe J.F. Tietge
Publikováno v:
Journal of Lipid Research, Vol 62, Iss , Pp 100083- (2021)
Lipoprotein-proteoglycan binding is an early key event in atherosclerotic lesion formation and thus conceivably could play a major role in vasculopathy-driven chronic graft failure and cardiovascular mortality in renal transplant recipients. The pres
Externí odkaz:
https://doaj.org/article/312aa0e994dc4f4996024c3265f8ebed
Autor:
John D. Douglass, Yin Xiu Zhou, Amy Wu, John A. Zadroga, Angela M. Gajda, Atreju I. Lackey, Wensheng Lang, Kristen M. Chevalier, Steven W. Sutton, Sui-Po Zhang, Christopher M. Flores, Margery A. Connelly, Judith Storch
Publikováno v:
Journal of Lipid Research, Vol 60, Iss 3, Pp 717- (2019)
Externí odkaz:
https://doaj.org/article/958579d899004c369825ee7df8364455
Autor:
John D. Douglass, Yin Xiu Zhou, Amy Wu, John A. Zadrogra, Angela M. Gajda, Atreju I. Lackey, Wensheng Lang, Kristen M. Chevalier, Steven W. Sutton, Sui-Po Zhang, Christopher M. Flores, Margery A. Connelly, Judith Storch
Publikováno v:
Journal of Lipid Research, Vol 56, Iss 6, Pp 1153-1171 (2015)
Monoacylglycerol lipase (MGL) is a ubiquitously expressed enzyme that catalyzes the hydrolysis of monoacylglycerols (MGs) to yield FFAs and glycerol. MGL contributes to energy homeostasis through the mobilization of fat stores and also via the degrad
Externí odkaz:
https://doaj.org/article/b971bbc51aba493cb64a321bc494f40f
Autor:
Jenson Qi, Wensheng Lang, John G. Geisler, Ping Wang, Ioanna Petrounia, Selyna Mai, Charles Smith, Hossein Askari, Geoffrey T. Struble, Robyn Williams, Sanjay Bhanot, Brett P. Monia, Shariff Bayoumy, Eugene Grant, Gary W. Caldwell, Matthew J. Todd, Yin Liang, Micheal D. Gaul, Keith T. Demarest, Margery A. Connelly
Publikováno v:
Journal of Lipid Research, Vol 53, Iss 6, Pp 1106-1116 (2012)
Diacylglycerol acyltransferase (DGAT) catalyzes the final step in triglyceride (TG) synthesis. There are two isoforms, DGAT1 and DGAT2, with distinct protein sequences and potentially different physiological functions. To date, the ability to determi
Externí odkaz:
https://doaj.org/article/bd9cb90a4bc84a398c5c84be64b6a2a9
Autor:
Andrew L. Darrow, Matthew W. Olson, Hong Xin, Sharon L. Burke, Charles Smith, Celine Schalk-Hihi, Robyn Williams, Shariff S. Bayoumy, Ingrid C. Deckman, Matthew J. Todd, Bruce P. Damiano, Margery A. Connelly
Publikováno v:
Journal of Lipid Research, Vol 52, Iss 2, Pp 374-382 (2011)
Endothelial lipase (EL) is a phospholipase A1 (PLA1) enzyme that hydrolyzes phospholipids at the sn-1 position to produce lysophospholipids and free fatty acids. Measurement of the PLA1 activity of EL is usually accomplished by the use of substrates
Externí odkaz:
https://doaj.org/article/629a71b67d5a4d33bf52e845fd601090
Autor:
Jenson Qi, Wensheng Lang, Edward Giardino, Gary W. Caldwell, Charles Smith, Lisa K. Minor, Andrew L. Darrow, Gustaaf Willemsens, Katharina DeWaepenaert, Peter Roevens, Joannes T.M. Linders, Yin Liang, Margery A. Connelly
Publikováno v:
Journal of Lipid Research, Vol 51, Iss 12, Pp 3559-3567 (2010)
Acyl-CoA:diacylglycerol acyltransferase (DGAT) catalyzes the terminal step in triglyceride (TG) synthesis using diacylglycerol (DAG) and fatty acyl-CoA as substrates. In the liver, the production of VLDL permits the delivery of hydrophobic TG from th
Externí odkaz:
https://doaj.org/article/adcb468b74c344d7843f3780adbc81d2
Autor:
Bing Sun, Boris B. Boyanovsky, Margery A. Connelly, Preetha Shridas, Deneys R. van der Westhuyzen, Nancy R. Webb
Publikováno v:
Journal of Lipid Research, Vol 48, Iss 12, Pp 2560-2570 (2007)
Modified forms of LDL, including oxidized low density lipoprotein (OxLDL), contribute to macrophage lipid accumulation in the vessel wall. Despite the pathophysiological importance of uptake pathways for OxLDL, the molecular details of OxLDL endocyto
Externí odkaz:
https://doaj.org/article/67dddbcdee3a4d2faf9756f64d64df49
Autor:
Saj Parathath, Yolanda F. Darlington, Margarita de la Llera Moya, Denise Drazul-Schrader, David L. Williams, Michael C. Phillips, George H. Rothblat, Margery A. Connelly
Publikováno v:
Journal of Lipid Research, Vol 48, Iss 6, Pp 1386-1395 (2007)
Scavenger receptor class B type I (SR-BI) facilitates the uptake of HDL cholesteryl esters (CEs) in a two-step process involving binding of HDL to its extracellular domain and transfer of HDL core CEs to a metabolically active membrane pool, where th
Externí odkaz:
https://doaj.org/article/1cfb97852d2649a19505f406f852a02c
Autor:
Patricia G. Yancey, Bela F. Asztalos, Nicolas Stettler, David Piccoli, David L. Williams, Margery A. Connelly, George H. Rothblat
Publikováno v:
Journal of Lipid Research, Vol 45, Iss 9, Pp 1724-1732 (2004)
Alagille syndrome is associated with bile duct paucity resulting in liver disease. Patients can be divided into mildly and severely icteric groups, with both groups having altered lipoproteins. The incidence of ischemic heart disease is rare in sever
Externí odkaz:
https://doaj.org/article/16b46dd850e34b2783537882de5a86a2
Autor:
Patricia G. Yancey, Masa-aki Kawashiri, Ryan Moore, Jane M. Glick, David L. Williams, Margery A. Connelly, Daniel J. Rader, George H. Rothblat
Publikováno v:
Journal of Lipid Research, Vol 45, Iss 2, Pp 337-346 (2004)
The effects of in vivo modulation of HDL phospholipid (PL) on scavenger receptor class BI (SR-BI)- and ATP binding cassette transporter 1 (ABCA1)-mediated efflux were examined by overexpressing either endothelial lipase (EL) or phosphatidylserine pho
Externí odkaz:
https://doaj.org/article/a1bd48865b4f4803b0e167d06a227fff