Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Makoto Kurano"'
Publikováno v:
Journal of Lipid Research, Vol 62, Iss , Pp 100029- (2021)
Abstract: Lysophosphatidic acid (LPA) is a potent signaling lipid, and state-dependent alterations in plasma LPA make it a promising diagnostic marker for various diseases. However, plasma LPA concentrations vary widely among reports, even under norm
Externí odkaz:
https://doaj.org/article/cb71ac2ab8934d2da7c4365a9589d3f0
Publikováno v:
Journal of Lipid Research, Vol 62, Iss , Pp 100120- (2021)
Diabetic nephropathy is a major complication of diabetes mellitus, and thus novel biomarkers are desired to evaluate the presence and progression of diabetic nephropathy. In this study, we sought to identify possible metabolites related to diabetic n
Externí odkaz:
https://doaj.org/article/1f45a5d4d5794151884afcbec77bc4f9
Autor:
Shigenobu Emoto, Makoto Kurano, Kuniyuki Kano, Keisuke Matsusaki, Hiroharu Yamashita, Masako Nishikawa, Koji Igarashi, Hitoshi Ikeda, Junken Aoki, Joji Kitayama, Yutaka Yatomi
Publikováno v:
Journal of Lipid Research, Vol 58, Iss 4, Pp 763-771 (2017)
Lysophosphatidic acid (LysoPA) has been proposed to be involved in the pathogenesis of various cancers. Moreover, glycero-lysophospholipids (glycero-LysoPLs) other than LysoPA are now emerging as novel lipid mediators. Therefore, we aimed to elucidat
Externí odkaz:
https://doaj.org/article/3afd00bd40da437890bd6f0c71418d4d
Autor:
Makoto Kurano, Kuniyuki Kano, Tomotaka Dohi, Hirotaka Matsumoto, Koji Igarashi, Masako Nishikawa, Ryunosuke Ohkawa, Hitoshi Ikeda, Katsumi Miyauchi, Hiroyuki Daida, Junken Aoki, Yutaka Yatomi
Publikováno v:
Journal of Lipid Research, Vol 58, Iss 2, Pp 433-442 (2017)
Lysophosphatidic acids (LysoPAs) and lysophosphatidylserine (LysoPS) are emerging lipid mediators proposed to be involved in the pathogenesis of acute coronary syndrome (ACS). In this study, we attempted to elucidate how LysoPA and LysoPS become elev
Externí odkaz:
https://doaj.org/article/01cdbcb81252448da73579c87eec4b46
Autor:
Makoto Kurano, Masumi Hara, Koichi Tsuneyama, Koji Okamoto, Naoyuki Iso-O, Teruhiko Matsushima, Kazuhiko Koike, Kazuhisa Tsukamoto
Publikováno v:
Journal of Lipid Research, Vol 53, Iss 11, Pp 2275-2285 (2012)
Niemann-Pick C1-like 1 protein (NPC1L1), a transporter crucial in intestinal cholesterol absorption, is expressed in human liver but not in murine liver. To elucidate the role of hepatic NPC1L1 on lipid metabolism, we overexpressed NPC1L1 in murine l
Externí odkaz:
https://doaj.org/article/7447357244564a1cacfb3b61ca739c16
Autor:
Mengxuan Liu, Megumi Honjo, Reiko Yamagishi, Nozomi Igarashi, Natsuko Nakamura, Makoto Kurano, Yutaka Yatomi, Koji Igarashi, Makoto Aihara
Publikováno v:
Biomolecules; Volume 12; Issue 9; Pages: 1231
This study examines the potential role of transforming growth factor-beta 3 (TGF-β3) on the fibrotic response of cultured human trabecular meshwork (HTM) cells. The relationships and trans-signaling interactions between TGF-β3 and autotaxin (ATX) i
Autor:
Sayaka Harada, Yoshitaka Taketomi, Toshiki Aiba, Mai Kawaguchi, Tetsuya Hirabayashi, Baasanjav Uranbileg, Makoto Kurano, Yutaka Yatomi, Makoto Murakami
Publikováno v:
Biomolecules. 13:471
The in vivo roles of lysophospholipase, which cleaves a fatty acyl ester of lysophospholipid, remained unclear. Recently, we have unraveled a previously unrecognized physiological role of the lysophospholipase PNPLA7, a member of the Ca2+-independent
Publikováno v:
Prostaglandins & Other Lipid Mediators. 164:106690
Bioactive lipids, such as lysophospholipids, ceramides, and eicosanoids and related mediators, have been demonstrated to be involved in inflammation. We aimed to investigate the possible orchestral modulations of these bioactive lipids in human infla
Autor:
Makoto Kurano, Masahiko Sumitani, Yoshiyuki Akiyama, Masaki Yamada, Daiki Fujimura, Satoshi Yamaki, Kuniyuki Kano, Junken Aoki, Kentaro Hayakawa, Takuya Takahashi, Takashi Hirai, Atsushi Okawa, Haruki Kume, Toru Ogata, Sakae Tanaka, Hirotaka Chikuda, Yutaka Yatomi
Publikováno v:
Clinica Chimica Acta. 541:117249
Autor:
Eriko Morita, Junken Aoki, Yoshifumi Morita, Satoshi Shimamoto, Motoji Sawabe, Makoto Kurano, Yutaka Yatomi, Koji Igarashi
Publikováno v:
Clinica Chimica Acta. 509:156-165
Background While basic researches have shown the involvement of the autotaxin-lysophosphatidic acid (ATX-LPA) axis in the pathogenesis of kidney diseases, no clinical studies have revealed the association between urinary ATX concentrations and kidney