Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Jorge Cruz-Reyes"'
Autor:
Zachary T Goodall, Wenshe R. Liu, Miriam A. Giardini, Arthur Laganowsky, Claudia M. Calvet, Jiyun Zhu, Kai S Yang, Jana Gomez, Diane Thomas, Chien-Te K Tseng, Balachandra Chenna, A. Joshua Wand, Jair L. Siqueira-Neto, Linfeng Li, Aleksandra Drelich, Zahra Moghadamchargari, Jean A. Bernatchez, Lauren R Blankenship, Drake M. Mellott, Jorge Cruz-Reyes, Thomas D. Meek, Taylor R. Cole, Elizabeth Alvarez Hernandez, Andrew Rademacher
Publikováno v:
Journal of medicinal chemistry. 64(15)
Cysteine proteases comprise an important class of drug targets, especially for infectious diseases such as Chagas disease (cruzain) and COVID-19 (3CL protease, cathepsin L). Peptide aldehydes have proven to be potent inhibitors for all of these prote
Autor:
Jorge Cruz-Reyes, Joshua Meehan, Karissa Hughes, Pawan K. Doharey, Shelly Gulati, Vikas Kumar, Mary Grace Martinez, Blaine H. M. Mooers
Publikováno v:
PLoS ONE
PLoS ONE, Vol 14, Iss 4, p e0211525 (2019)
PLoS ONE, Vol 14, Iss 4, p e0211525 (2019)
Uridylate insertion/deletion RNA editing inTrypanosoma bruceiis a complex system that is not found in humans, so there is interest in targeting this system for drug development. This system uses hundreds of small non-coding guide RNAs (gRNAs) to modi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86526f60b24f7c8ab3a3e12703e89126
https://doi.org/10.1101/524702
https://doi.org/10.1101/524702
Publikováno v:
WIREs RNA. 9
Publikováno v:
WIREs RNA. 9
RNA editing causes massive remodeling of the mitochondrial mRNA transcriptome in trypanosomes and related kinetoplastid protozoa. This type of editing involves the specific insertion or deletion of uridylates (U) directed by small noncoding guide RNA
Autor:
Bhaskara R. Madina, Michael Kinter, Kevin Ro, Alfredo J. Hernandez, Belinda Willard, James A. Wohlschlegel, Jorge Cruz-Reyes
Publikováno v:
Journal of Biological Chemistry. 285:1220-1228
Regulation of gene expression in kinetoplastid mitochondria is largely post-transcriptional and involves the orchestration of polycistronic RNA processing, 3′-terminal maturation, RNA editing, turnover, and translation; however, these processes rem
Autor:
Alevtina G. Zhelonkina, Julie A. Law, Jorge Cruz-Reyes, Barbara Sollner-Webb, Catherine E. Huang, Vadim S. Alatortsev, Sean F. O'Hearn
Publikováno v:
RNA. 12:476-487
Trypanosome RNA editing is massive post-transcriptional U-insertion and U-deletion, which generates mature mRNA coding regions through cycles of endonuclease, terminal U transferase (TUTase) or 3′-U-exo, and ligase action. Both types of editing are
Autor:
Blaine H. M. Mooers, Chiedza Kanyumbu, Shelly Gulati, Vikas Kumar, Danielle Lane, Jorge Cruz-Reyes
Publikováno v:
Acta Crystallographica Section A Foundations and Advances. 73:a381-a381
Publikováno v:
The EMBO Journal. 16:4069-4081
Kinetoplastid mitochondrial RNA editing, the insertion and deletion of U residues, is catalyzed by sequential cleavage, U addition or removal, and ligation reactions and is directed by complementary guide RNAs. We have purified a approximately 20S en
Autor:
Barbara Sollner-Webb, Jorge Cruz-Reyes
Publikováno v:
Proceedings of the National Academy of Sciences. 93:8901-8906
We have studied the mechanism of accurate in vitro RNA editing of Trypanosoma brucei ATPase 6 mRNA, using four mRNA-guide RNA (gRNA) pairs that specify deletion of 2, 3, or 4 U residues at editing site 1 and mitochondrial extract. This extract not on
Autor:
Alfredo J. Hernandez, Kenneth Stuart, Catherine Cifuentes-Rojas, Aswini K. Panigrahi, Jorge Cruz-Reyes, Anastasia Sacharidou
Publikováno v:
Journal of molecular biology. 381(1)
U-insertion/deletion RNA editing in the single mitochondrion of kinetoplastids, an ancient lineage of eukaryotes, is a unique mRNA maturation process needed for translation. Multisubunit editing complexes recognize many pre-edited mRNA sites and modi