Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Jinle Tang"'
Autor:
Jinle Tang, Yi Zheng, Lipei Fang, Juanli Pan, Yaoqi Zhou, Yunxia Xu, Wei Xu, Yanhong Ma, Jian Zhan, Yingshou Lei, Danting Zhang, Xin Chen, Ke Chen, Bao Zhang
Publikováno v:
International Journal of Biological Macromolecules
COVID-19 is a disease caused by SARS-CoV-2, which has led to more than 4 million deaths worldwide. As a result, there is a worldwide effort to develop specific drugs for targeting COVID-19. Papain-like protease (PLpro) is an attractive drug target be
Autor:
Hao Huang, Beihua Dong, Frank Sicheri, Yize Li, Robert H. Silverman, Jinle Tang, Christina Gaughan, Daniel Mao, Shuvojit Banerjee, Nicolas Tavernier, Gerald D. Gish, Manisha Talukdar, Salima Daou, Susan R. Weiss, Babal K. Jha, Abiodun A. Ogunjimi, Nicole M. Duffy
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance The OAS–RNase L system is an innate immunity pathway activated by viral infection. Viral dsRNA stimulates OAS enzymes to produce short 2′,5′-oligoadenylates (2-5A) that activate RNase L, resulting in cleavage of single-stranded (ss
Autor:
Ziyang Fu, Zhihong Liu, Yingjie Wang, Jihui Li, Yuxin Ye, Jinle Tang, Jiali Gao, Dante Neculai, Manisha Talukdar, Hao Huang, Huan Zhou
Publikováno v:
Biochemical Journal. 477:3387-3399
The pseudokinase (PK) RNase L is a functional ribonuclease and plays important roles in human innate immunity. The ribonuclease activity of RNase L can be regulated by the kinase inhibitor sunitinib. The combined use of oncolytic virus and sunitinib
Autor:
Jinle Tang, Zhengshuang Xu, Robert H. Silverman, Abhishek Asthana, Christina Gaughan, Guoliang Zhang, Hao Huang, Huan Zhou, Ming Liu, Beihua Dong, Xiaogang Niu, Shuyan Liu
Publikováno v:
Journal of medicinal chemistry. 65(2)
The pseudokinase-endoribonuclease RNase L plays important roles in antiviral innate immunity and is also implicated in many other cellular activities. The inhibition of RNase L showed therapeutic potential for Aicardi-Goutieres syndrome (AGS). Thus,
Autor:
Ziyang Fu, Bin Huang, Jinle Tang, Shuyan Liu, Ming Liu, Yuxin Ye, Zhihong Liu, Yuxian Xiong, Dan Cao, Jihui Li, Xiaogang Niu, Huan Zhou, Yong Juan Zhao, Guoliang Zhang, Hao Huang
SARS-CoV-2 is the pathogen responsible for the COVID-19 pandemic. The SARS-CoV-2 papain-like cysteine protease has been implicated in virus maturation, dysregulation of host inflammation and antiviral immune responses. We showed that PLpro preferably
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4f78589d342e21e7519c712edd0b2664
https://doi.org/10.1101/2020.07.17.208959
https://doi.org/10.1101/2020.07.17.208959
Autor:
Lin Qi, Saad Z. Usmani, George Mulligan, Jinle Tang, Heather Lin, Isere Kuiatse, Jiexin Zhang, Jianliang Xu, Bin Li, Wencai Ma, Bingzong Li, Bart Barlogie, Robert Z. Orlowski, H. Wang, Zhiqiang Wang, Richard E. Davis, John Crowley, Xingding Zhang, Lin Yang, Veerabhadran Baladandayuthapani, Walter Hunziker, Qing Zhang, Antje Hoering, Jin He, Dixie-Lee Esseltine, Jing Yang
Publikováno v:
Blood. 124:3414-3414
Background: Proteasome inhibitors (PIs) are important agents against myeloma, but innate and acquired resistance limit their effectiveness. We previously found Tight junction protein (TJP)-1 to be a modulator and potential biomarker of PI sensitivity