Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Jeffrey E. DeClue"'
Autor:
Alex G. Papageorge, Douglas R. Lowy, Jeffrey E. DeClue, Xiaolan Qian, Pieter H. Anborgh, William C. Vass
Publikováno v:
Molecular and Cellular Biology. 19:4611-4622
Ras GTPases, which play a pivotal role as transducers of various mitogenic and differentiation signals, function as molecular switches, cycling between an inactive GDP-bound state and an active GTP-bound state (33). Ras is negatively regulated by GTP
Publikováno v:
Journal of Biological Chemistry. 272:29301-29308
Tuberous sclerosis is an autosomal dominant disorder characterized by the development of benign growths in many tissues and organs. Linkage analysis revealed two disease-determining genes on chromosome 9 and chromosome 16. The TSC2 gene on chromosome
Autor:
Alma F. Ferrier, Douglas R. Lowy, Giovanna Benvenuto, Deborah K. Morrison, Jeffrey E. DeClue, Wayne B. Anderson, Michael Lee
Publikováno v:
Journal of Biological Chemistry. 272:2136-2142
The Raf-1 serine/threonine protein kinase plays a central role in many of the mitogenic signaling pathways regulating cell growth and differentiation. The regulation of Raf-1 is complex, and involves protein-protein interactions as well as changes in
Publikováno v:
Journal of Biological Chemistry. 270:16409-16414
Tuberous sclerosis (TSC) is a human genetic syndrome characterized by the development of benign tumors in a variety of tissues, as well as rare malignancies. Two different genetic loci have been implicated in TSC; one of these loci, the tuberous scle
Publikováno v:
Trends in genetics : TIG. 7(11-12)
The ras genes encode GTP/GDP-binding proteins that participate in mediating mitogenic signals from membrane tyrosine kinases to downstream targets. The activity of p21ras is determined by the concentration of GTP-p21ras, which is tightly regulated by
Publikováno v:
JAIDS Journal of Acquired Immune Deficiency Syndromes. 5:308
The nef protein of the BH8 clone derived from the IIIB isolate of human immunodeficiency virus 1 (HIV-1) has a molecular weight of 27,000, whereas that produced by a clone of the BRU strain of HIV-1 appears to have a molecular weight of 24,800. To de