Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Jeffery, H"'
Autor:
Keith Blomenkamp, Kyle Stearns, Tina Zelonina, Jeffery H. Teckman, Rui Xiao, Monica P. Goldklang, Jeanine D'Armiento
Publikováno v:
PLoS ONE, Vol 16, Iss 2, p e0246040 (2021)
PLoS ONE
PLoS ONE
Alpha-1 Antitrypsin (AAT) is a serum protease inhibitor that regulates increased lung protease production induced by cigarette smoking. Mutations in the Serpina1 gene cause AAT to form hepatoxic polymers, which can lead to reduced availability for th
Autor:
Amy L. Patton, Laura P. James, William E. Fantegrossi, Keith R. McCain, Jeffery H. Moran, Anna Radominska-Pandya, Paul L. Prather, Ryoichi Fujiwara, Azure L. Yarbrough, Kathryn A. Seely
Publikováno v:
Biochemical and Biophysical Research Communications. 498:597-602
Synthetic cannabinoids (SCBs), synonymous with ‘K2’, ‘Spice’ or ‘synthetic marijuana’, are psychoactive drugs of abuse that frequently result in clinical effects and toxicity more severe than those classically associated with Δ9-tetrahyd
Publikováno v:
Drug Metabolism Letters. 7:34-38
“K2” or “Spice” is an emerging drug of abuse that is laced with psychoactive synthetic cannabinoids JWH-018 and AM2201. Previous studies have identified hydroxylated (OH) and carboxylated (COOH) species as primary human metabolites, and kinet
Autor:
Matthew Trass, Gregory W. Endres, Amy L. Patton, Paul J. Dobrowolski, Krishna C. Chimalakonda, Art Miranda, Laura P. James, William E. Fantegrossi, Keith R. McCain, Kathryn A. Seely, Johnny P Tran, Jeffery H. Moran, Paul D. Kennedy, Anna Radominska-Pandya
Publikováno v:
Analytical Chemistry. 85:9390-9399
Designer synthetic cannabinoids like JWH-018 and AM2201 have unique clinical toxicity. Cytochrome-P450-mediated metabolism of each leads to the generation of pharmacologically active (ω)- and (ω-1)-monohydroxyl metabolites that retain high affinity
Publikováno v:
Toxicology and Applied Pharmacology. 269:100-108
K2 or Spice is an emerging drug of abuse that contains synthetic cannabinoids, including JWH-018 and JWH-073. Recent reports indicate that monohydroxylated metabolites of JWH-018 and JWH-073 retain high affinity and activity at cannabinoid type-1 rec
Autor:
Laura P. James, Cindy L. Moran, Jeffery H. Moran, Krishna C. Chimalakonda, Lisa K. Brents, Kathryn A. Seely, Paul F. Hollenberg, Gregory W. Endres, Anna Radominska-Pandya, Stacie M. Bratton, Paul L. Prather
Publikováno v:
Drug Metabolism and Disposition. 40:2174-2184
Abuse of synthetic cannabinoids (SCs), such as [1-naphthalenyl-(1-pentyl-1H-indol-3-yl]-methanone (JWH-018) and [1-(5-fluoropentyl)-1H-indol-3-yl]-1-naphthalenyl-methanone (AM2201), is increasing at an alarming rate. Although very little is known abo
Autor:
Tamara Vasiljevik, William E. Fantegrossi, Thomas E. Prisinzano, Anna Gallus-Zawada, Paul L. Prather, Anna Radominska-Pandya, Jeffery H. Moran, Lisa K. Brents
Publikováno v:
Biochemical Pharmacology. 83:952-961
K2 and several similar purported “incense products” spiked with synthetic cannabinoids are abused as cannabis substitutes. We hypothesized that metabolism of JWH-073, a prevalent cannabinoid found in K2, contributes to toxicity associated with K2
Autor:
Jeffery H. Moran, Vi-Huyen Le, Kan Hui Nicole Yiew, Anna Dineva, Krishna C. Chimalakonda, Cindy L. Moran, Stacie M. Bratton, Anna Radominska-Pandya, Laura P. James
Publikováno v:
Drug Metabolism and Disposition. 39:1967-1976
K2, a synthetic cannabinoid (SC), is an emerging drug of abuse touted as "legal marijuana" and marketed to young teens and first-time drug users. Symptoms associated with K2 use include extreme agitation, syncope, tachycardia, and visual and auditory
Autor:
Grover P. Miller, Jeffery H. Moran, Chul-Ho Yun, Michael J. Guderyon, So-Young Kim, Drew R. Jones
Publikováno v:
Chemical Research in Toxicology. 23:939-945
Coumadin (R/S-warfarin) anticoagulant therapy poses a risk to over 50 million Americans, in part due to interpersonal variation in drug metabolism. Consequently, it is important to understand how metabolic capacity is influenced among patients. Cytoc
Publikováno v:
Drug Metabolism Reviews. 42:55-61
The widely prescribed anticoagulant, Coumadin (racemic R/S-warfarin), Bristol-Myers Squibb Company, Clinton, NY has a narrow therapeutic range and wide interindividual response due, in part, to drug metabolism. Early identification of hydroxywarfarin