Zobrazeno 1 - 10
of 141
pro vyhledávání: '"James A. Brown"'
Publikováno v:
Polymer Chemistry. 13:3116-3125
Chain-transfer ring-opening metathesis polymerization (CT-ROMP) provided a route to carboxytelechelic polyethylene (PE) with subsequent incorporation into segmented copolymers.
Autor:
Isaac Ampong, O. John Ikwuobe, James E.P. Brown, Clifford J. Bailey, Dan Gao, Jorge Gutierrez-Merino, Helen R. Griffiths
Publikováno v:
The international journal of biochemistrycell biology. 143
Epidemiological studies show that higher circulating levels of odd chain saturated fatty acids (FA: C15:0 and C17:0) are associated with lower risk of metabolic disease. These odd chain saturated fatty acids (OCSFA) are produced by α-oxidation in pe
Autor:
Yaping Wang, Phillip B. Hylemon, Williams M. Pandak, Lanming Chen, Shunlin Ren, Weiqi Lin, James E. Brown
Publikováno v:
Journal of Lipid Research, Vol 62, Iss, Pp 100063-(2021)
Journal of Lipid Research
Journal of Lipid Research
The oxysterol sulfate, 25-hydroxycholesterol 3-sulfate (25HC3S), has been shown to play an important role in lipid metabolism, inflammatory response, and cell survival. However, the mechanism(s) of its function in global regulation is unknown. The cu
Autor:
Rebecca D. Dodd, Marion Vanneste, Michael B. Cohen, Patrick Breheny, Wade R. Gutierrez, James A. Brown, Michael D. Henry, Devon L. Moose, Nadine Bannick, Courtney Yong, Robert U. Svensson
Publikováno v:
PLoS ONE
PLoS ONE, Vol 15, Iss 9, p e0232807 (2020)
PLoS ONE, Vol 15, Iss 9, p e0232807 (2020)
Here we have improved an existing mouse model of prostate cancer based on prostate-specific deletion of Pten and Trp53 by incorporating a Cre-activatable luciferase reporter. By coupling the deletion of those genes to the activation of a luciferase r
Autor:
David E. Hibbs, Stephen J. Fuller, James O'Brien-Brown, Leanne Stokes, Michael Kassiou, Melissa L. Barron, Kristen K. Skarratt, Danielle J. Vugts, Eryn L. Werry, Mansoor Chishty, Albert D. Windhorst, Shane M. Wilkinson, Jennifer Ong, Bieneke Janssen
Publikováno v:
ACS Chemical Neuroscience, 8(11), 2374-2380. American Chemical Society
Wilkinson, S M, Barron, M L, O'Brien-Brown, J, Janssen, B, Stokes, L, Werry, E L, Chishty, M, Skarratt, K K, Ong, J A, Hibbs, D E, Vugts, D J, Fuller, S, Windhorst, A D & Kassiou, M 2017, ' Pharmacological Evaluation of Novel Bioisosteres of an Adamantanyl Benzamide P2X 7 Receptor Antagonist ', ACS Chemical Neuroscience, vol. 8, no. 11, pp. 2374-2380 . https://doi.org/10.1021/acschemneuro.7b00272
Wilkinson, S M, Barron, M L, O'Brien-Brown, J, Janssen, B, Stokes, L, Werry, E L, Chishty, M, Skarratt, K K, Ong, J A, Hibbs, D E, Vugts, D J, Fuller, S, Windhorst, A D & Kassiou, M 2017, ' Pharmacological Evaluation of Novel Bioisosteres of an Adamantanyl Benzamide P2X 7 Receptor Antagonist ', ACS Chemical Neuroscience, vol. 8, no. 11, pp. 2374-2380 . https://doi.org/10.1021/acschemneuro.7b00272
Adamantanyl benzamide 1 was identified as a potent P2X7R antagonist but failed to progress further due to poor metabolic stability. We describe the synthesis and SAR of a series of bioisosteres of benzamide 1 to explore improvements in the pharmacolo
Autor:
James O'Brien-Brown, Michael Kassiou, Tristan A. Reekie, Sarah L. Bowyer, Erick C.N. Wong, Eryn L. Werry
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 27:2439-2442
We report on P2X7 receptor antagonists based on a lead adamantly-cyanoguanidine-aryl moiety. We have investigated the importance of the central cyanoguanidine moiety by replacing it with urea, thiourea or guanidine moieties. We have also investigated
Publikováno v:
Biochemical Society Transactions
Two opposing enzyme classes regulate fundamental elements of genome maintenance, gene regulation and metabolism, either through addition of an acetyl moiety by histone acetyltransferases (HATs) or its removal by histone de-acetyltransferases (HDAC),
Autor:
Samuel P. Forry, Matthew D. Wallenstein, Ophelia S. Venturelli, Christer Jansson, Costas D. Maranas, James B. Brown, Stephen R. Lindemann, Scott W. Behie, Elizabeth A. Shank, Nitin S. Baliga, José R. Dinneny, Scott A. Jackson, Jennifer Pett-Ridge, Hans C. Bernstein, Trent R. Northen, Karsten Zengler, Matthias Hess, Sheri A. Floge, Kirsten S. Hofmockel
Publikováno v:
Nature methods. 16(7)
Microbiomes play critical roles in ecosystems and human health, yet in most cases scientists lack standardized and reproducible model microbial communities. The development of fabricated microbial ecosystems, which we term EcoFABs, will provide such
Autor:
James A. Brown
Publikováno v:
Current Protocols in Pharmacology. 79
Acetylation is a core cellular process involved in maintaining genomic integrity, gene regulation, and metabolism. Histone acetyltransferases (HATs) are an enzyme family that regulates these processes by catalyzing the transfer of an acetyl moiety on
Autor:
Paul McVeigh, Stephanie Paul, Matthew Rice, Kamela O. Alegre, Christopher J. Law, Scarlett R. Holdsworth, James A. Brown, Sharon M. Kelly
Publikováno v:
Molecular Microbiology. 92:872-884
Summary Resistance to high concentrations of bile salts in the human intestinal tract is vital for the survival of enteric bacteria such as Escherichia coli. Although the tripartite AcrAB-TolC efflux system plays a sig- nificant role in this resistan