Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Huilin Zhao"'
Publikováno v:
Biochemical and Biophysical Research Communications. 626:114-120
New variations of SARS-CoV-2 continue to emerge in the global pandemic, which may be resistant to at least some vaccines in COVID-19, indicating that drug and vaccine development must be continuously strengthened. NSP10 plays an essential role in SAR
Autor:
Huilin Zhao, Xiaocui Wu, Bingjie Wang, Li Shen, Lulin Rao, Xinyi Wang, Jiao Zhang, Yanghua Xiao, Yanlei Xu, Jingyi Yu, Yinjuan Guo, Ying Zhou, Baoshan Wan, Chunyang Wu, Liang Chen, Fangyou Yu
Publikováno v:
mSystems.
ST22 MRSA (methicillin-resistant Staphylococcus aureus ) strains are only sporadically reported in China. Through the phylogenetic reconstruction of 30 ST22 strains from China and 480 ST22 strains from global sources, we found that the global ST22 st
Autor:
Xinyi Wang, Xiaocui Wu, Li Shen, Lulin Rao, Bingjie Wang, Huilin Zhao, Jiao Zhang, Yanghua Xiao, Yinjuan Guo, Yanlei Xu, Liang Chen, Fangyou Yu
Publikováno v:
mSystems. 8
Methicillin-resistant Staphylococcus aureus ST45 is epidemic worldwide. This study contributed to the awareness of the Chinese hyper-virulent MRSA ST45 strains and served as a timely reminder of its wide dissemination of clonotypes. Further, we provi
Autor:
Jie Li, Xin He, Jin Wang, Weijie Wu, Yuanjie Hao, Ziwei Wang, Huilin Zhao, Wei Cui, Meng Yao, Cong Xia
Publikováno v:
Sensors (Basel, Switzerland)
Sensors, Vol 21, Iss 3848, p 3848 (2021)
Sensors
Volume 21
Issue 11
Sensors, Vol 21, Iss 3848, p 3848 (2021)
Sensors
Volume 21
Issue 11
Pixel-based semantic segmentation models fail to effectively express geographic objects and their topological relationships. Therefore, in semantic segmentation of remote sensing images, these models fail to avoid salt-and-pepper effects and cannot a
Autor:
Yulong Wu, Huilin Zhao, Zheng Xu, Xiaofei Ji, Xuelian Bai, Boqing Li, Yunfei Ding, Ran Ma, Qianyu Rong, Ying Zhang
Publikováno v:
Frontiers in Microbiology, Vol 10 (2019)
Helicobacter pylori is the etiologic agent in a variety of gastroduodenal diseases. As its key pathogenic factors, both urease and Hsp60 play important roles in the pathogenesis of H. pylori. Previous studies have suggested that there is close relati
Autor:
Weiwei Yan, Jing Tang, Fuming Wu, Yongli Zhang, Huilin Zhao, Yu Sun, Keke Feng, Zhiming Sun, Jianping Gao
Publikováno v:
Reactive and Functional Polymers. 148:104504
Inverse opal hydrogel films composed of hydroxyethyl 2-methacrylate and phenylboronic acid (IOHGHEMA+3APBA) were prepared by a convenient ultrasonic-induced self-assembly method. The IOHGHEMA+3APBA films had brilliant blue-violet color when they were
Autor:
Xin Huang, Susan M. Turci, Zihao Hua, Randy Serafino, Liyue Huang, Jin Tang, Jason Brooks Human, Ryan White, Lisa Acquaviva, Jennifer Dovey, Barbara Grubinska, Oleg Epstein, Doug Saffran, Huilin Zhao, Steve Schneider, Howard Bregman, Hongbing Huang, Anne B. O’Connor, Violeta Yu, John Newcomb, Jonathan T. Goldstein, Nagasree Chakka, Matthew W. Martin, Vinod F. Patel, Craig A. Strathdee, Virginia Berry, Alexander M. Long, Cindy Wilson, Erin F. DiMauro, Hakan Gunaydin
Publikováno v:
ACS Medicinal Chemistry Letters. 3:1059-1064
Aberrant activation of the Wnt pathway is believed to drive the development and growth of some cancers. The central role of CK1γ in Wnt signal transduction makes it an attractive target for the treatment of Wnt-pathway dependent cancers. We describe
Publikováno v:
Journal of Medicinal Chemistry. 55:956-960
Casein kinase 1 delta (CK1δ) and its closest homologue CK1ε are key regulators of diverse cellular growth and survival processes such as Wnt signaling, DNA repair, and circadian rhythms. We report three crystal structures of the kinase domain of hu
Autor:
Ji-Rong Sun, Steve Bellon, Paul Gallant, Michael Morrison, Richard Kendall, Holly L. Deak, Karina Romero, Robert Radinsky, Patrick Eden, Kelly Hanestad, Laurie B. Schenkel, Alan C. Cheng, Paul E. Rose, Huilin Zhao, Victor J. Cee, Marc Payton, Min-Hwa Jasmine Lin, Vinod F. Patel, Xuhai Be, Stephanie D. Geuns-Meyer, Tammy L. Bush, Hanh Nho Nguyen, Steve Coats, Philip R. Olivieri, Annette Bak, Xin Huang, Brian L. Hodous, Grace Tin-Yun Chung, Jin Tang, Yan Gu, Sandra Ross
Publikováno v:
Journal of Medicinal Chemistry. 53:6368-6377
The discovery of aurora kinases as essential regulators of cell division has led to intense interest in identifying small molecule aurora kinase inhibitors for the potential treatment of cancer. A high-throughput screening effort identified pyridinyl
Autor:
Matthew R. Lee, John G. Allen, Jon Scherrer, Anne B. O’Connor, Christy Boucher, Philip Roveto, David Bauer, William G. Richards, Philip Babij, Russell Graceffa, Shaun Flynn, Chun-Ya E. Han, Huilin Zhao
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:4924-4928
A screening campaign of a diverse collection of approximately 250,000 small molecule compounds was performed to identify inhibitors of proline-rich tyrosine kinase 2 (Pyk2) with potential osteogenic activity in osteoblast cells. Compounds were priori