Zobrazeno 1 - 10
of 155
pro vyhledávání: '"Hiroyuki Watanabe"'
Publikováno v:
ACS Chemical Neuroscience. 13:2982-2990
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals.
Publikováno v:
ACS Chemical Neuroscience. 13:16-26
Deposition of α-synuclein (α-syn) aggregates is one of the neuropathological hallmarks of synucleinopathies including Parkinson's disease, dementia with Lewy bodies, and multiple-system atrophy. In vivo detection of α-syn aggregates with SPECT or
Publikováno v:
ACS medicinal chemistry letters. 13(10)
We have reported that the chelator-based clickable radiotheranostic platform, ADIBO-DOTADG-ALB (ADA), has favorable properties as a radiotheranostic platform for low-molecular-weight ligands. In this study, we evaluated the applicability of ADA to mo
Publikováno v:
ACS medicinal chemistry letters. 13(10)
Synucleinopathies are characterized by the deposition of α-synuclein (α-syn) aggregates before the onset of clinical symptoms. Therefore
Autor:
Hiroyuki Watanabe, Yoichi Shimizu, Shimpei Iikuni, Yuji Nakamoto, Yuta Tarumizu, Sho Kaide, Masahiro Ono
Publikováno v:
ACS Med Chem Lett
[Image: see text] Noninvasive imaging of tau aggregates with a positron emission tomography (PET) tracer is useful for the diagnosis and staging of Alzheimer’s disease (AD). Recently, we found that benzimidazopyridine (BIP) is an attractive scaffol
Autor:
Hiroyuki Watanabe, Rinka Maekawa, Shimpei Iikuni, Masashi Kakae, Nagisa Matsuo, Hisashi Shirakawa, Shuji Kaneko, Masahiro Ono
Publikováno v:
ACS chemical neuroscience. 13(3)
Multiple sclerosis (MS) is an intractable disease of the central nervous system that results from destruction of the myelin sheath. Direct measurement of de- and remyelination is required for monitoring the disease stage of MS, but no useful method h
Publikováno v:
ACS Med Chem Lett
[Image: see text] Tau aggregate, which is the main component of the neurofibrillary tangle, is an attractive imaging target for diagnosing and monitoring the progression of Alzheimer’s disease (AD). In this study, we designed and synthesized six ra
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 62:885-891
Labeling agents with radioisotopes or fluorescent dyes are useful for investigating the biodistributions of biologically active proteins and peptides. Compared with molecular imaging with a single modality, dual imaging probes provide complementary i
Autor:
Hiroyuki Watanabe, Takeaki Kishimoto, Masahiro Ono, Yuta Tarumizu, Sho Kaide, Haruka Tatsumi, Shimpei Iikuni
Publikováno v:
ACS Med Chem Lett
[Image: see text] The accumulation of hyperphosphorylated tau protein in the brain is regarded as one of the hallmarks of Alzheimer’s disease (AD). In vivo imaging of tau aggregates is helpful for diagnosis and monitoring of the progression of AD.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8ed422a1886827a03c4c210cb4d4a5d
https://europepmc.org/articles/PMC8155298/
https://europepmc.org/articles/PMC8155298/