Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Haigang Ren"'
Autor:
Jun-Jie Niu, Wan-Lin Zhang, Feng Zhang, Xiao-Lin Yang, Qian Xu, Yu-Fang Pei, Gui-Juan Feng, Zi-Jia Zhang, Haigang Ren, Zi-Xuan Lin, Xin-Tong Wei, Shan-Shan Yan, Bai-Xue Han, Hong Zhang, Lei Zhang, Jing-Jing Ni, Rong Hai
Publikováno v:
The Journal of clinical endocrinology and metabolism. 106(9)
Background Age at natural menopause (ANM) is an important index for women’s health. Either early or late ANM is associated with a series of adverse outcomes later in life. Despite being an inheritable trait, its genetic determinant has not yet been
Autor:
Guanghui Wang, Xingshun Xu, Chenchen Mu, Zongbing Hao, Dongkai Guo, Haigang Ren, Shun Zhang, Xingyun Xu, Hongyang Sun
Publikováno v:
The Journal of biological chemistry. 293(14)
Abelson helper integration site 1 (AHI1) is associated with several neuropsychiatric and brain developmental disorders, such as schizophrenia, depression, autism, and Joubert syndrome. Ahi1 deficiency in mice leads to behaviors typical of depression.
Publikováno v:
FEBS Letters. 582:1151-1156
Sumoylation is an important post-translational modification, which is also involved in the pathogenesis of many neurodegenerative diseases. We previously reported that DJ-1 decreases Bcl-2 associated X protein expression through repressing p53 transc
Publikováno v:
Journal of Biological Chemistry. 283:4022-4030
DJ-1, originally identified as an oncogene product, is a protein with various functions in cellular transformation, oxidative stress response, and transcriptional regulation. Although previous studies suggest that DJ-1 is cytoprotective, the mechanis
Publikováno v:
Cell Death & Disease
Parkinson’s disease (PD) is the second most prevalent neurodegenerative disease. Although its pathogenesis remains unclear, mitochondrial dysfunction plays a vital role in the pathology of PD. P7C3, an aminopropyl carbazole, possesses a significant
Publikováno v:
Molecular neurobiology. 52(3)
Poly-ubiquitinated protein aggregate formation is the most striking hallmark of various neurodegenerative diseases such as Alzheimer's disease, Huntington's disease, amyotrophic lateral sclerosis, and prion disease. Mutations of many ubiquitin-associ
Publikováno v:
The Journal of biological chemistry. 286(40)
Parkinson disease (PD)- and cancer-associated protein, DJ-1, mediates cellular protection via many signaling pathways. Deletions or mutations in the DJ-1 gene are directly linked to autosomal recessive early-onset PD. DJ-1 has potential roles in mito
Autor:
Guanghui Wang, Hongfeng Wang, Bin Li, Longping Wen, Na Man, Nobuyuki Nukina, Haigang Ren, Qingsong Hu, E Fei
Publikováno v:
Cell death and differentiation. 17(11)
Omi, also known as high temperature requirement factor A2 (HtrA2), is a serine protease that was originally identified as a proapoptotic protein. Like Smac/Diablo, it antagonizes inhibitor of apoptosis proteins when released into the cytosol on apopt