Zobrazeno 21 - 30
of 54
pro vyhledávání: '"H Stacey"'
Autor:
Samy A. Azer, Neill H. Stacey
Publikováno v:
Biochemical pharmacology. 42(10)
Autor:
Vicki Kefalas, Neill H. Stacey
Publikováno v:
Toxicology and applied pharmacology. 109(1)
A number of chemicals are known to potentiate the hepatotoxicity of carbon tetrachloride. The halocarbon trichloroethylene was shown in a previous study to enhance both carbon tetrachloride-induced toxicity and lipid peroxidation in isolated hepatocy
Publikováno v:
Chemico-biological interactions. 77(3)
Transport of endogenous chemicals both into (at the basolateral membrane) and out of (at the canalicular membrane) hepatocytes plays an important role in bile formation. Hence, interference with these processes, for example by chemicals, may result i
Autor:
Masoud Neghab, Neill H. Stacey
Publikováno v:
Toxicology Letters. 95:228
Autor:
Neill H. Stacey, Curtis D. Klaassen
Publikováno v:
Toxicology and Applied Pharmacology. 58:8-18
The role of lipid peroxidation in tissue injury has been the subject of many investigations. Recently evidence has suggested that lipid peroxidation due to various chemicals is directly responsible for loss of hepatocyte viability. In the present stu
Autor:
Neill H. Stacey
Publikováno v:
Toxicology in Vitro. 3:137-143
Hepatocyte suspensions were exposed to carbon tetrachloride (CT), chloroform (CF) or 1,1,1-trichloroethane (TE) or the various combinations of these three chemicals over a 3-hr incubation period. Enhanced toxicity, as determined by loss of intracellu
Autor:
Ludwig Müller, Neill H. Stacey
Publikováno v:
Biological Trace Element Research. 21:317-323
Effects of cadmium (Cd) in vivo and in vitro were studied in the absence of enhanced metallothionein (MT) production and overt Cd toxicity. Such a condition was established by extended oral exposure of male rats to 0.2 mumols Cd/kg and by incubation
Autor:
Neill H. Stacey
Publikováno v:
Immunopharmacology. 8:155-161
Ethanol has been shown to inhibit spontaneous cell-mediated cytotoxicity and antibody-dependent cell-mediated cytotoxicity in vitro in a dose-dependent manner. The effect was observed under differing assay conditions such as incubation time and effec
Publikováno v:
Toxicology and Applied Pharmacology. 53:470-480
The toxicity of cadmium may be due to alteration in membrane structure which may be caused by peroxidation of the composite lipids. Isolated hepatocytes provide a suitable system to examine the role of lipid peroxidation in a toxic response at the ce
Autor:
Neill H. Stacey, Curtis D. Klaassen
Publikováno v:
Journal of Toxicology and Environmental Health. 7:139-147
Various mechanisms, including increases in lipid peroxidation, have been proposed to account for metal-induced cellular injury. By comparing several metals in the same cell population, it is possible to determine whether a correlation exists between