Zobrazeno 11 - 20
of 54
pro vyhledávání: '"H Stacey"'
Publikováno v:
Biomedical Chromatography. 4:136-140
A high performance liquid chromatographic (HPLC) method for analysis of 4 free and 8 conjugated bile acids in submicromolar quantities in serum is described using precolumn derivatization with 4-bromomethyl-7-methoxycoumarin (BMC) and fluorescence de
Publikováno v:
Hepatology. 11:750-756
Isolated rat hepatocytes have been advocated as a model to study aspects of mechanism of chemicalinduced interference with biliary excretory function. Some technical problems do exist in studying efflux, such as the reuptake of the previously excrete
Publikováno v:
Toxicology and Applied Pharmacology. 102:80-90
The effects of chlorinated aliphatic hydrocarbon solvent exposure on hepatocellular transport of some model substrates have been investigated. Exposure of isolated hepatocytes to 1,1,1-trichloroethane or tetrachloroethylene resulted in suppression of
Publikováno v:
Biochemical Pharmacology. 42:193-195
Autor:
Masoud Neghab, Neill H. Stacey
Publikováno v:
Journal of toxicology and environmental health. 52(3)
Raised concentrations of serum bile acids (SBA) following occupational exposure to a number of halogenated aliphatic hydrocarbon solvents and after in vivo exposure of experimental animals to these substances have been reported in several studies in
Publikováno v:
International archives of occupational and environmental health. 70(3)
Objectives: The objectives of this study were␣threefold. First, to examine the hepatic effects of occupational exposure to 1,1,2-trichloro-1,2,2-trifluoroethane (FC 113) using conventional and newer tests (serum bile acids) of hepatobiliary functio
Autor:
Neill H. Stacey, Shu-Xin Qu
Publikováno v:
Carcinogenesis. 17(1)
Exposure of humans to polycyclic aromatic hydrocarbons is an ongoing concern because of the carcinogenicity of these substances. DNA adducts are being increasingly used as indicators of carcinogen exposure. While considerable experimental evidence ex
Autor:
Masoud Neghab, Neill H. Stacey
Publikováno v:
Toxicology in vitro : an international journal published in association with BIBRA. 10(2)
In recent years workers in our laboratory have shown that several industrial chlorinated aliphatic hydrocarbon solvents interfere with the transport of bile acids by hepatocytes and this interference may account for the raised concentration of serum
Publikováno v:
Toxicology in vitro : an international journal published in association with BIBRA. 8(2)
Sinudoisal and canalicular plasma membranes were prepared from rat and fresh or frozen human liver and characterized using plasma membrane marker enzymes. The distributions of these enzymes were used as a means of comparison between the plasma membra
Autor:
Neill H. Stacey, C.L. Bai
Publikováno v:
Toxicology in vitro : an international journal published in association with BIBRA. 7(3)
The hepatotoxic effects of chlorinated hydrocarbon solvents have been well recognized for many years. More recently serum bile acids (SBA) have been considered as a sensitive indicator for the determination of liver dysfunction. However, changes in S