Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Giorgi, G."'
Autor:
Gianluca Giorgi, Samantha Zanoli, Michela Di Mattia, Anna Ramunno, Giuseppe Campiani, Stefania Butini, Sandra Gemma, Alberto Bergamini, Salvatore Sanna Coccone, Giuseppe Borrelli, Sandro Cosconati, Luciana Marinelli, Margherita Brindisi, Alberta Samuele, Bruno Galletti, Ettore Novellino, Giovanni Maga, Silvana Lalli
Starting from the prototypic compound 4, we describe new, potent, and broad-spectrum pyrrolobenzo(py-rido)oxazepinones antivirals. A biochemical and enzymological investigation was performed for defining their mechanism of inhibition at either recomb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::454e0a9f045019b65519412b67085301
http://hdl.handle.net/11365/3650
http://hdl.handle.net/11365/3650
Autor:
Maurizio Anzini, Giulia Chemi, Alessia Chelini, Germano Giuliani, Angela Di Capua, Lorenzo Di Cesare Mannelli, Gianluca Giorgi, Concettina La Motta, Annalisa Reale, Massimo Valoti, Antonietta Rossi, Lidia Sautebin, Simona Pace, Marco Paolino, Elena Lucarini, Andrea Cappelli, Simone Brogi, Alessandro Grillo, Carla Ghelardini
A novel series of 1,5-diarylpyrrol-3-sulfur derivatives (10–12) was synthesized and characterized by NMR and mass spectroscopy and x-ray diffraction. The biological activity of these compounds was evaluated in in vitro and in vivo tests to assess t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6820359b41e3db181ca2676dc960a721
http://hdl.handle.net/11588/766499
http://hdl.handle.net/11588/766499
Nitrobutadienes as powerful benzannulating agents: An unprecedented easy access to rare nitroindoles
Autor:
Gianluca Giorgi, Angela Pagano, Lara Bianchi, Giovanni Petrillo, Michele Mancinelli, Massimo Maccagno, Cinzia Tavani
We report herein an original protocol to the indole nucleus, which could contribute to significantly expand the synthetic access to a heterocyclic moiety of undeniable paramount importance. The protocol consists in the construction of the benzene rin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35cc39c85954abdfa17ca5317bed1f27
http://hdl.handle.net/11365/1081768
http://hdl.handle.net/11365/1081768
Autor:
Lisa Dalla Via, Alessandra Silvani, Gaia Fumagalli, Franco Dosio, Giulia Giorgi, Eleonora Colombo, Daniele Passarella, Mariafrancesca Hyeraci, Monica Montopoli, Máté Vágvölgyi, Davide Prosperi, Giordano Lesma, Michael S. Christodoulou, Veronica Collico, Attila Hunyadi
[Image: see text] Heteronanoparticles (H-NPs) consisting of conjugates characterized by a squalene tail linked to doxorubicin and ecdysteroid derivatives are presented. Biological evaluation on A2780ADR cell line confirms not only the maintenance of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77cce67c1eed97aaa040b4363671e489
https://europepmc.org/articles/PMC5949839/
https://europepmc.org/articles/PMC5949839/
Autor:
Annamaria Martorana, Silvestre Buscemi, Antonio Palumbo Piccionello, Gianluca Giorgi, Andrea Pace
Publikováno v:
Org. Biomol. Chem.. 9:491-496
A novel base-induced rearrangement of isoxazoles into imidazole derivatives is reported. In the isoxazole series, this represents the first example of a three-atom side-chain rearrangement involving a CNC sequence. The reactions are carried out under
Autor:
Steven B. Karch, Vittorio Fineschi, Margherita Neri, Giorgio Giorgi, Carmela Fiore, Daniela Cerretani, Irene Riezzo, Cristoforo Pomara, F. Centini, Emanuela Turillazzi, Stefano D'Errico, Anna Ida Fiaschi
Publikováno v:
International Journal of Legal Medicine. 122:461-469
Experimental and clinical data indicate that 3,4-methylenedioxy-N-methylamphetamine (MDMA) abuse can produce significant cardiovascular toxicity. A mechanism may be a direct toxic effect of redox active metabolites of MDMA. To evaluate the effect of
Autor:
Daniela Cerretani, Angela Bruna Maffione, Carmela Fiore, Cristoforo Pomara, Pasini Franco Laghi, Cristina Nencini, Lucia Micheli, Stefano D'Errico, Anna Ida Fiaschi, Emanuela Turillazzi, Giorgio Giorgi, Pietro Euea Lazzerini, Margherita Neri, Irene Riezzo, Giancarlo Bruni, Vittorio Fineschi
Publikováno v:
Journal of Cellular and Molecular Medicine
Background: To investigate the cardiotoxic role of reactive oxygen species (ROS) and of products derived from catecholamines auto-oxidation, we studied: (1) the response of antioxidant cardiac cellular defence systems to oxidative stress induced by n
Publikováno v:
Tetrahedron Letters. 50:1472-1474
The reaction of 3-ethoxycarbonyl-5-perfluoroalkyl-1,2,4-oxadiazoles with hydroxylamines has been investigated, evidencing the possibility of competitive reaction paths. Nucleophilic addition of hydroxylamine to the electrophilic C(5) of the 1,2,4-oxa
Autor:
Gianfranco Giorgi, Brunella Del Re
Publikováno v:
Mobile Genetic Elements
Long interspersed nuclear elements -1 (LINEs, L1s) are retroelements occupying almost 17% of the human genome. L1 retrotransposition can cause deleterious effects on the host-cell and it is generally inhibited by suppressive mechanisms, but it can oc
Autor:
Gianluca Giorgi, Sandra Gemma, O Taglialatela-Scafati, Bhupendra Prasad Joshi, Silvio Caccia, Giuseppe Campiani, Mario Salmona, Claudia Fracasso, Ettore Novellino, Isabella Fiorini, Stefania Butini, Gianluigi Forloni, Margherita Brindisi, Luisa Savini, Laura Colombo, Pierangela Tripaldi
Publikováno v:
Organicbiomolecular chemistry. 9(14)
Here we describe the identification and preliminary characterization of a new class of pyrrolo(imidazo)quinoxaline hydrazones as flurescent probes for Aβ 1-42 fibrils. All the newly developed compounds were able to bind amyloid fibrils formed in vit