Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Dara K. Mohammad"'
Autor:
Laurent Schmied, Thuy T. Luu, Jonas N. Søndergaard, Sophia H. Hald, Stephan Meinke, Dara K. Mohammad, Sunitha B. Singh, Corinna Mayer, Giovanna Perinetti Casoni, Michael Chrobok, Heinrich Schlums, Giorgia Rota, Hieu M. Truong, Lisa S. Westerberg, Greta Guarda, Evren Alici, Arnika K. Wagner, Nadir Kadri, Yenan T. Bryceson, Mezida B. Saeed, Petter Höglund
Publikováno v:
Science Signaling. 16
Natural killer (NK) cells recognize virally infected cells and tumors. NK cell function depends on balanced signaling from activating receptors, recognizing products from tumors or viruses, and inhibitory receptors (such as KIR/Ly49), which recognize
Translocation-generated ITK-FER and ITK-SYK fusions induce STAT3 phosphorylation and CD69 expression
Autor:
C. I. Edvard Smith, Dara K. Mohammad, Samir El Andaloussi, Rula Zain, Narmeen N. Fathi, André Görgens, Beston F. Nore
Publikováno v:
Biochemical and Biophysical Research Communications. 504:749-752
Many cancer types carry mutations in protein tyrosine kinase (PTK) and such alterations frequently drive tumor progression. One category is gene translocation of PTKs yielding chimeric proteins with transforming capacity. In this study, we characteri
Autor:
C. I. Edvard Smith, Dara K. Mohammad, Abdalla J. Mohamed, Manuela O. Gustafsson, Beston F. Nore
Publikováno v:
The International Journal of Biochemistry & Cell Biology. 78:63-74
The Protein kinase B (AKT) regulates a plethora of intracellular signaling proteins to fine-tune signaling of multiple pathways. Here, we found that following B-cell receptor (BCR)-induced tyrosine phosphorylation of the cytoplasmic tyrosine kinase S
Autor:
K E M Blomberg, A. Hamasy, C. I. E. Smith, Anna Berglöf, Mauno Vihinen, Liang Yu, Dara K. Mohammad, Qing Wang
Publikováno v:
Leukemia
Irreversible Bruton tyrosine kinase (BTK) inhibitors, ibrutinib and acalabrutinib have demonstrated remarkable clinical responses in multiple B-cell malignancies. Acquired resistance has been identified in a sub-population of patients in which mutati
Autor:
Dara K. Mohammad, Hernando Yesid Estupiñan Velasquez, Anna Berglöf, Qing Wang, Edvard C.I. Smith, Rula Zain, Yuye Shi, Mauno Vihinen
Publikováno v:
Blood. 134:5759-5759
Resistance to the irreversible Bruton´s tyrosine kinase (BTK) inhibitors is the main cause of disease progression in patients with Chronic Lymphocytic Leukemia (Quinquenel et. al. Blood 2019). Cysteine to serine substitution at the position 481 in B
Publikováno v:
PLoS ONE
PLoS ONE, Vol 11, Iss 8, p e0160255 (2016)
PLoS ONE, Vol 11, Iss 8, p e0160255 (2016)
Protein kinase B (AKT) phosphorylates numerous substrates on the consensus motif RXRXXpS/T, a docking site for 14-3-3 interactions. To identify novel AKT-induced phosphorylation events following B cell receptor (BCR) activation, we performed proteomi
Autor:
Qing Wang, C. I. Edvard Smith, Dara K. Mohammad, Kalle Saksela, Hyunseok Choi, Subhash Shrestha, Manuela O. Gustafsson, Erkko Ylösmäki, Beston F. Nore
Publikováno v:
PLoS ONE
PLoS ONE, Vol 12, Iss 4, p e0174909 (2017)
PLoS ONE, Vol 12, Iss 4, p e0174909 (2017)
Bruton's Tyrosine Kinase (BTK) is a cytoplasmic protein tyrosine kinase with a fundamental role in B-lymphocyte development and activation. The nucleocytoplasmic shuttling of BTK is specifically modulated by the Ankyrin Repeat Domain 54 (ANKRD54) pro
Autor:
Dara K. Mohammad, Merve Uslu, C. I. Edvard Smith, Abdalla J. Mohamed, Abdulrahman Hamasy, Alamdar Hussain, Manuela O. Gustafsson, Beston F. Nore
The inducible T cell kinase-spleen tyrosine kinase (ITK-SYK) oncogene consists of the Tec homology-pleckstrin homology domain of ITK and the kinase domain of SYK, and it is believed to be the cause of peripheral T cell lymphoma. We and others have re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::931a30690e2fe15a0d6b22f129b7f6d3
https://europepmc.org/articles/PMC3591642/
https://europepmc.org/articles/PMC3591642/