Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Dalian Ding"'
Autor:
Hong Sun, Jeanne M. Manalo, Dalian Ding, John Hicks, Richard Salvi, Fred A. Pereira, Rodney E. Kellems, Yang Xia, Hong Liu
Publikováno v:
The FASEB Journal. 34:15771-15787
Over 466 million people worldwide are diagnosed with hearing loss (HL). About 90% of HL cases are sensorineural HL (SNHL) with treatments limited to hearing aids and cochlear implants with no FDA-approved drugs. Intriguingly, ADA-deficient patients h
Autor:
Shinichi Someya, Kevin Boyd, Hyo-Jin Park, Dalian Ding, Chul Han, Richard Salvi, Karessa White, Mi-Jung Kim
Publikováno v:
Exp Gerontol
The glutathione transferase (GST) detoxification system converts exogenous and endogenous toxins into a less toxic form by conjugating the toxic compound to reduced glutathione (GSH) by a variety of GST enzymes. Of the ~20 GST isoforms, GSTA4 exhibit
Autor:
Chul Han, Shinichi Someya, Kaitlyn Evans, Mi-Jung Kim, Suraiya Haroon, Marc Vermulst, Lijie Liu, Isabela Caicedo, Hyo-Jin Park, Guang-Di Chen, Paul J. Linser, Kevin Boyd, Masaru Tanokura, Dalian Ding, Jonathan Wanagat, Tomas A. Prolla, Richard Salvi, Karessa White, Yanping Zhang
Publikováno v:
Exp Gerontol
Mitochondrial DNA (mtDNA) mutations are thought to have a causal role in a variety of age-related neurodegenerative diseases, including age-related hearing loss (AHL). In the current study, we investigated the roles of mtDNA deletions and point mutat
Autor:
Peter Carmichael, Dalian Ding, Masaru Tanokura, Chul Han, Upal Bose, Richard Salvi, Karessa White, Mi-Jung Kim, Shinichi Someya, Kevin Boyd, Christina Rothenberger, Hyo-Jin Park, Paul J. Linser
Publikováno v:
Exp Gerontol
Thioredoxin 2 (TXN2) is a small redox protein found in nearly all organisms. As a mitochondrial member of the thioredoxin antioxidant defense system, TXN2 interacts with peroxiredoxin 3 (PRDX3) to remove hydrogen peroxide. Accordingly, TXN2 is though
Autor:
Richard Salvi, Dalian Ding, Masaru Tanokura, Chul Han, Zaimary Meneses, Karessa White, Paul J. Linser, Mi-Jung Kim, Hyo-Jin Park, Shinichi Someya
Glucose-6-phosphate dehydrogenase (G6PD) is the first and rate-limiting enzyme of the pentose phosphate pathway; it catalyzes the conversion of glucose-6-phosphate to 6-phosphogluconate and NADP+ to NADPH and is thought to be the principal source of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecbc76e893769737ba25ff7710998c66
https://europepmc.org/articles/PMC5469311/
https://europepmc.org/articles/PMC5469311/
Publikováno v:
BioMetals. 27:125-134
Divalent metal transporter 1 (DMT1) is generally considered to be the major transmembrane protein responsible for the uptake of a variety of divalent cations. Four isoforms of DMT1 have been identified in mammalian cells encoded by a single gene that
Autor:
Sneha Hinduja, Donald E. Coling, Jun Qu, Richard Salvi, Gail M. Seigel, Jun Li, Samson Jamesdaniel, Dalian Ding, Linda Cassidy
Publikováno v:
Journal of Biological Chemistry. 287:18674-18686
Tyrosine nitration is an important sequel of cellular signaling induced by reactive oxygen species. Cisplatin is an anti-neoplastic agent that damages the inner ear through reactive oxygen species and by the formation of DNA adducts. This study revea
Autor:
Dalian Ding, Mohammad Habiby Kermany, Samson Jamesdaniel, Bo Hua Hu, Richard Salvi, Haiyan Jiang, Donald E. Coling
Publikováno v:
Journal of Proteomics. 75:410-424
Noise exposure is a major cause of hearing loss. Classical methods of studying protein involvement have provided a basis for understanding signaling pathways that mediate hearing loss and damage repair but do not lend themselves to studying large net
Autor:
Dalian Ding, Jingchun He, Gail M. Seigel, Dongzhen Yu, Brian L. Allman, Haiyan Jiang, Richard Salvi
Publikováno v:
Hearing Research. 282:196-203
Ototoxicity is a dose-limiting side effect of chemotherapeutic treatment with cisplatin. In a series of experiments on neonatal rat cochlear organotypic cultures, the extent of damage induced by a broad range of cisplatin treatment concentrations was
Autor:
Mohammad Habiby Kermany, Bruce A. Davidson, Dalian Ding, Paul R. Knight, Richard Salvi, Donald E. Coling, Samson Jamesdaniel
Publikováno v:
Journal of Proteome Research. 7:3516-3524
Cisplatin, a widely used anticancer drug, preferentially damages outer hair cells (OHCs) of the inner ear. In this study, an antibody microarray was used to identify early changes in protein expression in the rat cochlea induced by cisplatin. Only sm