Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Christian Gaiddon"'
Autor:
Marta Martínez-Alonso, Albert Gandioso, Chloé Thibaudeau, Xue Qin, Philippe Arnoux, Nurikamal Demeubayeva, Vincent Guérineau, Céline Frochot, Alain C. Jung, Christian Gaiddon, Gilles Gasser
Publikováno v:
ChemBioChem
ChemBioChem, 2023, ⟨10.1002/cbic.202300203⟩
ChemBioChem, 2023, ⟨10.1002/cbic.202300203⟩
International audience; A novel Ru(II) cyclometalated photosensitizer (PS), Ru-NH2, for photodynamic therapy (PDT) of formula [Ru(appy)(bphen)2]PF6 (where appy = 4-amino-2-phenylpyridine and bphen = bathophenanthroline) and its cetuximab (CTX) biocon
Publikováno v:
Journal of Biological Inorganic Chemistry
Journal of Biological Inorganic Chemistry, 2022, 27 (4-5), pp.393-403. ⟨10.1007/s00775-022-01939-2⟩
Journal of Biological Inorganic Chemistry, 2022, 27 (4-5), pp.393-403. ⟨10.1007/s00775-022-01939-2⟩
International audience; Metal ion dysregulation has been implicated in a number of diseases from neurodegeneration to cancer. While defective metal ion transport mechanisms are known to cause specific diseases of genetic origin, the role of metal dys
Publikováno v:
Current opinion in chemical biology. 72
The p53 protein plays a critical role in the prevention of genome mutations in the body, however, this protein is frequently mutated in cancer and almost all cancers exhibit malfunction along the p53 pathway. In addition to a loss of activity, mutant
Autor:
Jessica J. Miller, Kalvin Kwan, Anaïs Blanchet, Christophe Orvain, Georg Mellitzer, Jason Smith, Cristina Lento, Lucienne Nouchikian, Sabrina Omoregbee-Leichnitz, Marie Sabatou, Derek Wilson, Christian Gaiddon, Tim Storr
Publikováno v:
Journal of Inorganic Biochemistry. 242:112164
Autor:
Jean-Noël Freund, Christian Gaiddon, Priscila da Silva Figueiredo Celestino Gomes, Gilles Riegel, Ronan Le Lagadec, Jean-Baptiste Delhorme, Catherine Tomasetto, Cynthia Licona, Ricardo Cerón-Camacho, Michel Pfeffer, Vania Vidimar, Georg Mellitzer, Isabelle Gross, Bastien Boff, Aina Venkatasamy, Didier Rognan
Publikováno v:
Inorganic Chemistry Frontiers
Inorganic Chemistry Frontiers, Royal Society of Chemistry, 2020, 7 (3), pp.678-688. ⟨10.1039/C9QI01148J⟩
Inorganic Chemistry Frontiers, Royal Society of Chemistry, 2020, 7 (3), pp.678-688. ⟨10.1039/c9qi01148j⟩
Inorganic Chemistry Frontiers, Royal Society of Chemistry, 2020, 7 (3), pp.678-688. ⟨10.1039/C9QI01148J⟩
Inorganic Chemistry Frontiers, Royal Society of Chemistry, 2020, 7 (3), pp.678-688. ⟨10.1039/c9qi01148j⟩
Ruthenium and osmium complexes have been shown to bypass several resistance mechanisms of platinum anticancer drugs, suggesting that they might represent therapeutic alternatives. However, the resistance mechanisms that may alter the cytotoxicity of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3821807e383b9c46a4c3ce35ca4296b2
https://hal.archives-ouvertes.fr/hal-03013615
https://hal.archives-ouvertes.fr/hal-03013615
Autor:
Alice Santoro, Peter Faller, Manuel David Peris-Díaz, Christian Gaiddon, Òscar Palacios, Bertrand Vileno, Gilles Riegel, Artur Krężel
Publikováno v:
Metallomics
Metallomics, Royal Society of Chemistry, 2019, 11 (5), pp.994-1004. ⟨10.1039/C9MT00061E⟩
Metallomics, Royal Society of Chemistry, 2019, 11 (5), pp.994-1004. ⟨10.1039/C9MT00061E⟩
Thiosemicarbazones (TSCs) are a class of strong metal ion ligands, which are currently being investigated for several applications, such as anticancer treatment. In addition to these ligands only, which exert their activity upon interaction with meta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::458ffbfdf03cd202b7b1be2708ead066
http://xlink.rsc.org/?DOI=C9MT00061E
http://xlink.rsc.org/?DOI=C9MT00061E
Autor:
Maria V. Babak, Wee Han Ang, Mun Juinn Chow, Giorgia Pastorin, Daniel Yuan Qiang Wong, Christian Gaiddon
Publikováno v:
Molecular Pharmaceutics
Molecular Pharmaceutics, 2016, 13 (7), pp.2543-2554. ⟨10.1021/acs.molpharmaceut.6b00348⟩
Molecular Pharmaceutics, American Chemical Society, 2016, 13 (7), pp.2543-2554. ⟨10.1021/acs.molpharmaceut.6b00348⟩
Molecular Pharmaceutics, 2016, 13 (7), pp.2543-2554. ⟨10.1021/acs.molpharmaceut.6b00348⟩
Molecular Pharmaceutics, American Chemical Society, 2016, 13 (7), pp.2543-2554. ⟨10.1021/acs.molpharmaceut.6b00348⟩
International audience; p53 is a key tumor suppressor gene involved in key cellular processes and implicated in cancer therapy. However, it is inactivated in more than 50% of all cancers due to mutation or overexpression of its negative regulators. T
Autor:
Jorge Andrés Solís-Ruiz, Anaïs Barthe, Rafael Omar Saavedra-Díaz, Ronan Le Lagadec, Christian Gaiddon, Gilles Riegel
Publikováno v:
Journal of Inorganic Biochemistry
Journal of Inorganic Biochemistry, Elsevier, 2020, 208, pp.111080. ⟨10.1016/j.jinorgbio.2020.111080⟩
Journal of Inorganic Biochemistry, Elsevier, 2020, 208, pp.111080. ⟨10.1016/j.jinorgbio.2020.111080⟩
Polypyridyl ruthenium complexes have been intensively investigated for their remarkable antiproliferative properties and some are currently being tested in clinical trials. Here, we investigated the impact of illumination on the biological properties
Autor:
Kwan Wei Tan, Mun Juinn Chow, Mei Chi Cheong, Christian Gaiddon, Wee Han Ang, Giorgia Pastorin, Maria V. Babak
Publikováno v:
Molecular Pharmaceutics
Molecular Pharmaceutics, 2018, 15 (8), pp.3020-3031. ⟨10.1021/acs.molpharmaceut.8b00003⟩
Molecular Pharmaceutics, American Chemical Society, 2018, 15 (8), pp.3020-3031. ⟨10.1021/acs.molpharmaceut.8b00003⟩
Molecular Pharmaceutics, 2018, 15 (8), pp.3020-3031. ⟨10.1021/acs.molpharmaceut.8b00003⟩
Molecular Pharmaceutics, American Chemical Society, 2018, 15 (8), pp.3020-3031. ⟨10.1021/acs.molpharmaceut.8b00003⟩
International audience; Current anticancer drug discovery efforts focus on the identification of first-in-class compounds with a mode-of-action distinct from conventional DNA-targeting agents for chemotherapy. An emerging trend is the identification
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::127630819ea87a98410b91db57739f58
https://www.hal.inserm.fr/inserm-02364152/document
https://www.hal.inserm.fr/inserm-02364152/document
Autor:
Christophe Orvain, Michel Pfeffer, Adel Hamada, Moussa Ali, Jennifer Weckbach, Houda Habbita, Christian Gaiddon
Publikováno v:
Journal of Organometallic Chemistry
Journal of Organometallic Chemistry, Elsevier, 2017, 845, pp.206-212. ⟨10.1016/j.jorganchem.2017.05.022⟩
Journal of Organometallic Chemistry, 2017, 845, pp.206-212. ⟨10.1016/j.jorganchem.2017.05.022⟩
Journal of Organometallic Chemistry, Elsevier, 2017, 845, pp.206-212. ⟨10.1016/j.jorganchem.2017.05.022⟩
Journal of Organometallic Chemistry, 2017, 845, pp.206-212. ⟨10.1016/j.jorganchem.2017.05.022⟩
International audience; Two novel cycloruthenated compounds, 2 and 3, derived from cycloruthenated 2-phenyl pyridine(Ru(PhPy)) have been synthesized by adding one equivalent of 2,20;60,200-terpyridine (terpy) to [Ru(2-C6H4-20-C5H4N-kC,N)(MeCN)4]PF6 i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a48050abfb0f582d9cbe6bd6832ddaa0
https://www.hal.inserm.fr/inserm-02365254/file/1-s2.0-S0022328X17303182-main.pdf
https://www.hal.inserm.fr/inserm-02365254/file/1-s2.0-S0022328X17303182-main.pdf