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pro vyhledávání: '"Azzu, A."'
Publikováno v:
Diabetes, Obesity and Metabolism. 12:134-140
Pancreatic β-cells have remarkable bioenergetics in which increased glucose supply upregulates the cytosolic ATP/ADP ratio and increases insulin secretion. This arrangement allows glucose-stimulated insulin secretion (GSIS) to be regulated by the co
Autor:
Martin D. Brand, Vian Azzu
Publikováno v:
Trends in Biochemical Sciences. 35:298-307
Mitochondrial uncoupling proteins disengage substrate oxidation from ADP phosphorylation by dissipating the proton electrochemical gradient that is required for ATP synthesis. In doing this, the archetypal uncoupling protein, UCP1, mediates adaptive
Autor:
Martin D. Brand, Vian Azzu
Publikováno v:
Journal of Cell Science. 123:578-585
Mitochondrial uncoupling protein 2 (UCP2) is implicated in a wide range of pathophysiological processes, including immunity and diabetes mellitus, but its rapid degradation remains uncharacterized. Using pharmacological proteasome inhibitors, immunop
Publikováno v:
Biochimica et Biophysica Acta
Glucose intolerance in C57Bl/6 mice has been associated with mutations in the nicotinamide nucleotide transhydrogenase (Nnt) gene. It has been proposed that the absence of NNT from mitochondria leads to increased mitochondrial reactive oxygen species
Publikováno v:
Biochimica et Biophysica Acta
Uncoupling protein 2 (UCP2) regulates glucose-stimulated insulin secretion in pancreatic beta-cells. UCP2 content, measured by calibrated immunoblot in INS-1E insulinoma cells (a pancreatic beta-cell model) grown in RPMI medium, and INS-1E mitochondr
Publikováno v:
Biochemical Journal
Mitochondria generate reactive oxygen species, whose downstream lipid peroxidation products, such as 4-hydroxynonenal, induce uncoupling of oxidative phosphorylation by increasing proton leak through mitochondrial inner membrane proteins such as the
UCP3 (uncoupling protein 3) and its homologues UCP2 and UCP1 are regulators of mitochondrial function. UCP2 is known to have a short half-life of approx. 1 h, owing to its rapid degradation by the cytosolic 26S proteasome, whereas UCP1 is turned over
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c35cf9d3afec64a25ab4f6b72e51f4f9
https://europepmc.org/articles/PMC3661275/
https://europepmc.org/articles/PMC3661275/
Publikováno v:
European biophysics journal : EBJ. 35(4)
Muscle myosins are molecular motors that convert the chemical free energy available from ATP hydrolysis into mechanical displacement of actin filaments, bringing about muscle contraction. Myosin cross-bridges exert force on actin filaments during a c
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Bioenergetics. (6-7):785-791
Uncoupling proteins (UCP1, UCP2 and UCP3) are important in regulating cellular fuel metabolism and as attenuators of reactive oxygen species production through strong or mild uncoupling. The generic function and broad tissue distribution of the uncou
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Bioenergetics. :S77