Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Andrew J. Gale"'
Autor:
Wolfram Ruf, Sriram Krishnaswamy, Jennifer N. Orje, Andrew J. Gale, Andrea S. Rothmeier, Yu-ichi Kamikubo, Lars Christian Petersen, Zaverio M. Ruggeri, Antonella Zampolli, G. Loredana Mendolicchio, Patrizia Marchese, Henrik Østergaard, Andras Gruber
Publikováno v:
Blood. 130:1661-1670
Safe and effective antithrombotic therapy requires understanding of mechanisms that contribute to pathological thrombosis but have a lesser impact on hemostasis. We found that the extrinsic tissue factor (TF) coagulation initiation complex can select
Publikováno v:
Thrombosis and Haemostasis
Thrombosis and Haemostasis, Schattauer, 2017, 83 (01), pp.78-85. ⟨10.1055/s-0037-1613761⟩
Thrombosis and Haemostasis, Schattauer, 2017, 83 (01), pp.78-85. ⟨10.1055/s-0037-1613761⟩
SummaryThree dimensional homology models for the C1 and C2 domains of factor VIII (FVIII) were generated. Each C domain formed a β-sandwich, and C1 was covalently connected to C2 in a head-to-head orientation. Of the >250 missense mutations that cau
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3492e588e6e8c7d871d2bae8f843dcd8
https://hal.archives-ouvertes.fr/hal-03274036
https://hal.archives-ouvertes.fr/hal-03274036
Autor:
Brennen Arthur Lynch, Andrew K. Udit, Zinaida Polonskaya, Ho Yong Cheong, Kevin Hong, Andrew J. Gale, M. G. Finn, Myles Groner, Jin Kyu Rhee, Michael M. Baksh, William Hollingsworth
Publikováno v:
Biomacromolecules. 18(12)
The anticoagulant activity of heparin administered during medical interventions must be reversed to restore normal clotting, typically by titrating with protamine. Given the acute toxicity associated with protamine, we endeavored to generate safer he
Publikováno v:
The FASEB Journal. 27:2918-2925
Protein S (PS) is a multifunctional plasma protein of the hemostatic and inflammatory pathways, although mechanisms for its regulation are poorly understood. Since certain plasma proteins are regulated through extracellular phosphorylation, we invest
Publikováno v:
Thrombosis and Haemostasis. 109:229-237
SummaryAnticoagulant plasma protein S (PS) is essential for maintaining haemostatic balance. About 2.5% of PS is stored in platelets and released upon platelet stimulation. So far, little is known about the functionality and importance of platelet (p
Publikováno v:
PROTEOMICS. 11:2377-2388
Proteases are critical in many physiological processes and the human genome encodes for 566 predicted proteolytic enzymes. Therefore, there is great interest in identifying and characterizing physiologic protease-substrate relationships. The coagulat
Publikováno v:
Protein Science. 11:2091-2101
Procoagulant factor Va (FVa) is inactivated via limited proteolysis at three Arg residues in the A2 domain by the anticoagulant serine protease, activated protein C (APC). Cleavage by APC at Arg306 in FVa causes dissociation of the A2 domain from the
Publikováno v:
Thrombosis and Haemostasis. 101:55-61
SummaryThe hypothesis that prothrombin (FII) protects coagulation factor Va (FVa) from proteolytic inactivation by activated protein C (APC) was tested using purified proteins. FII dose-dependently protected FVa from APC proteolysis under conditions
Publikováno v:
Journal of Biological Chemistry. 282:21848-21855
Prothrombin is proteolytically activated by the prothrombinase complex comprising the serine protease Factor (F) Xa complexed with its cofactor, FVa. Based on inhibition of the prothrombinase complex by synthetic peptides, FVa residues 493-506 were p
Autor:
K.-P. Radtke, John H. Griffin, Andrew J. Gale, D. Chamberlain, Jean-Luc Pellequer, M. A. Cunningham
Publikováno v:
Journal of Thrombosis and Haemostasis
Journal of Thrombosis and Haemostasis, Wiley, 2006, 4 (6), pp.1315-1322. ⟨10.1111/j.1538-7836.2006.01951.x⟩
Journal of Thrombosis and Haemostasis, 2006, 4 (6), pp.1315-1322. ⟨10.1111/j.1538-7836.2006.01951.x⟩
Journal of Thrombosis and Haemostasis, Wiley, 2006, 4 (6), pp.1315-1322. ⟨10.1111/j.1538-7836.2006.01951.x⟩
Journal of Thrombosis and Haemostasis, 2006, 4 (6), pp.1315-1322. ⟨10.1111/j.1538-7836.2006.01951.x⟩
Summary. Background: The utility of purified coagulation factor (F)VIII for treatment of hemophilia A is limited in part by its instability following activation by thrombin, which is caused by spontaneous dissociation of the A2 domain from the activa