Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Yan, Jun"'
Neto proteins regulate gating of the kainate-type glutamate receptor GluK2 through two binding sites
Autor:
Yong-Yun Shi, Chang Ye, Guiquan Chen, Yun Stone Shi, Dan Wu, Yan-Jun Li, Gui-Fang Duan, Jun Wang, Yan-Yu Zang, Wei Zhang, Jia-Hui Sun
Publikováno v:
J Biol Chem
The neuropilin and tolloid-like (Neto) proteins Neto1 and Neto2 are auxiliary subunits of kainate-type glutamate receptors (KARs) that regulate KAR trafficking and gating. However, how Netos bind and regulate the biophysical functions of KARs remains
Publikováno v:
ACS chemical neuroscience. 11(24)
Cerebral ischemia is accompanied by mitochondrial integrity destruction. Thus, reversion of mitochondrial damage holds great potential for cerebral ischemia therapy. As a crucial Bcl-2 family member, pro-apoptotic Bax protein is a main effector of mi
Publikováno v:
Molecular Medicine Reports
Bone marrow mesenchymal stem cells (BM-MSCs) regulate the balance between regulatory T cells (Tregs) and T helper 17 (Th17) cells. However, the role of different factors on BM-MSCs-mediated regulation of the Treg/Th17 balance is unknown. BM-MSCs and
Autor:
Jia-le Wang, Yu-Qiong Zhang, Yu-Dong Tian, Shu-Yao Zhou, Yong-Yan Jia, Yan-Jun Sun, Yan-Bin Guan
Publikováno v:
Journal of Huazhong University of Science and Technology [Medical Sciences]. 37:371-378
The therapeutic potential of curcumin (Cur) is hampered by its poor aqueous solubility and low bioavailability. The aim of this study was to determine whether Cur nanoemulsions enhance the efficacy of Cur against prostate cancer cells and increase th
Publikováno v:
Molecular and Cellular Biochemistry. 436:23-28
Although CO2 is produced during the oxidation of different substrates in all types of cells, the role of this gas in the regulation of cellular function is not clearly understood. Since changes in several signal transduction as well as apoptotic, ant
Publikováno v:
Brazilian Journal of Medical and Biological Research, Volume: 51, Issue: 7, Article number: e6201, Published: 17 MAY 2018
Brazilian Journal of Medical and Biological Research
Brazilian Journal of Medical and Biological Research v.51 n.7 2018
Associação Brasileira de Divulgação Científica (ABDC)
instacron:ABDC
Brazilian Journal of Medical and Biological Research, Vol 51, Iss 7 (2018)
Brazilian Journal of Medical and Biological Research
Brazilian Journal of Medical and Biological Research v.51 n.7 2018
Associação Brasileira de Divulgação Científica (ABDC)
instacron:ABDC
Brazilian Journal of Medical and Biological Research, Vol 51, Iss 7 (2018)
This study aimed to investigate the role of hypoxia-inducible factor-2α (HIF-2α) in the expression of tight junction proteins and permeability alterations in rat glomerular endothelial cells (rGENCs) under hypoxia conditions. The expression level o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d65c4f7e381d1aaca13b7bb52f8fb8c
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2018000700604&lng=en&tlng=en
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2018000700604&lng=en&tlng=en
Publikováno v:
Molecular Medicine Reports
Stroke is considered an underlying etiology of the development of seizures. Stroke leads to glucose and oxygen deficiency in neurons, resulting in brain dysfunction and injury. Mild hypothermia is a therapeutic strategy to inhibit stroke-induced seiz
Publikováno v:
The Journal of Membrane Biology. 246:365-373
Resveratrol (RSV), a natural polyphenolic antioxidant, has been considered an anticarcinogenic agent as it triggers tumor cell apoptosis through activation of the mitochondrial pathway. In our study, the effects of RSV on mitochondria, especially on
Autor:
Qi Wang, Feilong Zhang, Yu-Long Tong, Yi He, Haiting An, Wen-Jing Zhang, Xiaomin Wang, Yan Zheng, Yan-Jun Jia, Lin Dong, Hao-Bo Zhang, Yanjing Qian, Hailong Song
SUMMARY Aims: To explore the effect of fucoidan treatment on oxidative stress-mediated dopaminergic neuronal damage and its potential mechanisms. Methods: The effect of fucoidan was investigated in a 6-hydroxydopamine (6-OHDA) rat model of PD, an ani
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55f1abcc24e1361a380c754f2338c4cf
https://europepmc.org/articles/PMC6493059/
https://europepmc.org/articles/PMC6493059/
Publikováno v:
Molecular and Cellular Biochemistry. 263:151-162
Although low Na(+) is known to increase the intracellular Ca(2+) concentration ([Ca(2+)]i) in cardiac muscle, the exact mechanisms of low Na(+)-induced increases in [Ca(2+)]i are not completely defined. To gain information in this regard, we examined