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Publikováno v:
Biochemistry and Cell Biology. 100:28-36
Interleukin-1β, a key cytokine in gouty inflammation, is precisely regulated by the NLRP3 inflammasome and NF-κB. Our previous study demonstrated that paeonol suppressed IL-1β production in rats with monosodium urate (MSU)-induced arthritis. Wheth
Autor:
Tracy M. Josephs, Le Vi Dinh, Aaron DeBono, Karen J. Gregory, Ben Capuano, Katie Leach, Andrew N. Keller
Publikováno v:
ChemMedChem. 16:3451-3462
The calcium-sensing receptor (CaSR) is a clinical target in the treatment of hyperparathyroidism and related diseases. However, clinical use of approved CaSR-targeting drugs such as cinacalcet ( 1 ) is limited due to adverse side effects including hy
Publikováno v:
ACS Chemical Neuroscience. 12:2373-2384
Adenosine receptors (ARs) have been involved in neurodegenerative diseases such as Alzheimer disease, where oxidative stress contributes to neurodegeneration and cell death. Therefore, there is increasing interest in developing antioxidative strategi
Autor:
Motoo Yamasaki, Emiko Akashi, Sayaka Nagata, Nobuko Kuroishi, Kazuo Kitamura, Johji Kato, Shinya Ashizuka
Publikováno v:
The Journal of Biochemistry. 170:445-451
Adrenomedullin is a biologically active peptide with multiple functions. Here, we have developed a novel human serum albumin-adrenomedullin (HSA-AM) conjugate, which was synthesized by the covalent attachment of a maleimide derivative of adrenomedull
Autor:
John G. Kingma, Ismail Laher
Publikováno v:
Biochemical and Biophysical Research Communications. 540:56-60
Sex dependent differences in coronary artery vasoregulation may be due to variations in responses to endogenous vasoactive compounds including endothelin (ET-1) and nitric oxide (NO).Septal coronary arteries (200 μm) from healthy, sexually mature ma
Publikováno v:
ACS Chemical Neuroscience. 11:2978-2988
This study aimed to investigate whether the proinflammatory and pressor effects of endogenous angiotensin II (AngII) are mediated by binding to the AngII type 1 receptor (AT1R) and subsequently activating central Toll-like receptor 4 (TLR4) in the ro
Autor:
Keywan Mortezaee, Homayoon Bana Derakhshan, Jamal Majidpoor, Reza Shirazi, Alireza Zali, Fardin Fathi, Mohammad Taghi Joghataie, Fatemeh Moradi, Mehdi Ghasemzadeh Bariki, Zahra Khezri
Publikováno v:
Cell Biochemistry and Function. 39:267-276
Spinal cord injury (SCI) is a common devastating condition that causes neuronal loss and dysfunction. Neuroinflammation takes cardinal roles in the pathogenesis of SCI, and nucleotide-binding domain-like receptor protein 3 (NLRP3) inflammasome is a m
Autor:
Dirk Schepmann, Wilma Quaglia, Maria Vittoria Micioni Di Bonaventura, Bernhard Wünsch, Alessandro Piergentili, Alessandro Bonifazi, Giulio Vistoli, Fabio Del Bello, Pegi Pavletić, Carlo Cifani, Luca Botticelli, Gianfabio Giorgioni, Emanuela Micioni Di Bonaventura
Publikováno v:
ACS Chemical Neuroscience
In this paper, the benzo-cracking approach was applied to the potent sigma1 (σ1) receptor antagonist 1 to afford the less conformationally constrained 1,3-dioxane derivatives 2 and 3. To evaluate the effect of the increase in the distance between th
Publikováno v:
The FASEB Journal. 34:13993-14005
Many factors are involved in the process of nerve regeneration. Understanding the mechanisms regarding how these factors promote an efficient remyelination is crucial to deciphering the molecular and cellular processes required to promote nerve repai
Autor:
Saeed Esmaeili-Mahani, Ali Mohammad Pourrahimi, Mehdi Abbasnejad, Razieh Kooshki, Maryam Raoof
Publikováno v:
Pourrahimi, A M, Abbasnejad, M, Raoof, M, Esmaeili-Mahani, S & Kooshki, R 2021, ' The involvement of orexin 1 and cannabinoid 1 receptors within the ventrolateral periaqueductal gray matter in the modulation of migraine-induced anxiety and social behavior deficits of rats ', Peptides, vol. 146, 170651 . https://doi.org/10.1016/j.peptides.2021.170651
Peptides, 146:170651. Elsevier Inc.
Peptides, 146:170651. Elsevier Inc.
© 2021 Elsevier Inc.Orexin 1 receptors (Orx1R) and cannabinoid 1 receptors (CB1R) are implicated in migraine pathophysiology. This study evaluated the potential involvement of Orx1R and CB1R within the ventrolateral periaqueductal gray matter (vlPAG