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Autor:
Surya Sandeep Mullapudi, Yamini Gullapalli, Sridhar Vemulapalli, Naveen Babu Kilaru, Vijaya R. Dirisala, Ravindra Babu Pingili
Publikováno v:
Xenobiotica. 51:926-932
The aim of the present study was to investigate the effect of naringenin (4,5,7-trihydroxy flavonone) on the pharmacokinetics of metoprolol, a substrate of Cytochrome P-450 3A4 (CYP3A4), CYP2C9, and CYP2D6 in rats. Male Wistar rats were treated orall
Autor:
Fabio García-García, Mario Eduardo Acosta-Hernández, Luis Angel López-Muciño, Sergio Priego-Fernández, Carolina Peña-Escudero
Publikováno v:
Alcohol. 93:63-70
The reduction of sleep hours is a public health problem in contemporary society. It is estimated that humans sleep between 1.5 and 2 h less, per night, than 100 years ago. The reduction of sleep hours is a risk factor for developing cardiovascular, m
Autor:
Stefany Sousa Alves, Luciana Marangni Nolli, Marcus Vinicius von Zuben, Eloisa Dutra Caldas, Márcia Renata Mortari, Aline Pic-Taylor, Danilo Gustavo Rodrigues de Oliveira
Publikováno v:
Alcohol. 84:67-75
Ayahuasca is a hallucinogenic infusion used in religious rituals that has serotoninergic properties and may be a potential therapeutic option for drug addiction. In this study, Wistar rats had intermittent access to ethanol for 8 weeks, receiving wat
Autor:
Petr K. Anokhin, Olga Y. Frolova, Maria V. Belopolskaya, Vsevolod V. Pavshintsev, Ekaterina A. Kushnir, Maxim L. Lovat, Nikita A. Mitkin
Publikováno v:
Alcohol. 83:17-28
Chronic ethanol consumption in high doses is associated with constitutively elevated activity of the serum alcohol dehydrogenase I (ADH I) isoform, which demonstrates a high affinity not only for ethanol but also for a number of bioamine metabolites.
Publikováno v:
Journal of Biochemical and Molecular Toxicology. 36
The illicit abuse of anabolic steroids is associated with brutal aggression, which represents a serious health hazard and social threat. Boldenone is commonly used for doping by athletes and adolescents for esthetic purposes and to enhance performanc
Publikováno v:
Journal of biochemical and molecular toxicologyREFERENCES. 35(12)
Amiodarone (AMD), an antiarrhythmic drug, is used cautiously due to its lung toxicity that is characterized by alveolar inflammation followed by fatal fibrosis. AMD induces lung inflammation via increasing the alveolar macrophages and disturbing the
Publikováno v:
Journal of Biochemical and Molecular Toxicology. 35
Cisplatin-induced nephrotoxicity limits its wide application as a chemotherapeutic drug. Betaine is a natural trimethylglycine compound involved in several biological reactions. In this study, the protective effect of betaine against cisplatin-induce
Autor:
Ayman M. Mahmoud, Ahmed M. Sayed, Emad H.M. Hassanein, Eman K. Rashwan, Omnia A M Abd El-Ghafar, Marwa A. Ahmed
Publikováno v:
Journal of biochemical and molecular toxicologyREFERENCES. 35(11)
Hemorrhagic cystitis is a potentially deadly complication associated with radiation therapy and chemotherapy. This study explored the protective effect of edaravone (ED) on cyclophosphamide (CP)-induced hemorrhagic cystitis, oxidative stress, and inf
Publikováno v:
Journal of biochemical and molecular toxicologyREFERENCES. 35(11)
Although doxorubicin (DOX) is used in many cancer treatments, it causes neurotoxicity. In this study, the effect of thymoquinone (THQ), a powerful antioxidant, on DOX-induced neurotoxicity was evaluated. In total, 40 rats were used and 5 groups were
Autor:
Kenji Hashimoto, Yukihiko Shirayama, Tomihisa Niitsu, Nobuhisa Kanahara, Yuki Hirose, Yasunori Oda, Hiroshi Kimura, Masaomi Iyo, Kouhei Yoshino, Makoto Kimura
Publikováno v:
Pharmacology, biochemistry, and behavior. 211
Background The excessive blockade of dopamine D2 receptors (DRD2s) with long-term antipsychotic treatment is known to induce a dopamine supersensitivity state (DSS). The mechanism of DSS is speculated to be a compensatory up-regulation of DRD2s, but