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Publikováno v:
J Med Chem
Snyder Robinson Syndrome (SRS) is a rare disease associated with a defective spermine synthase gene and low intracellular spermine levels. In this study, a spermine replacement therapy was developed using a spermine prodrug that enters cells via the
Publikováno v:
Neurochemical Research. 46:3059-3074
Paraquat (PQ), an environmental neurotoxicant, causes acute fatal poisoning upon accidental or intentional ingestion (suicidal cases) worldwide. To date, an effective remedy for PQ toxicity is not available. In this study, we have evaluated the thera
Autor:
Robert K Leśniak, Steven Andrew Baker, Curt R. Fischer, Nay L. Saw, Kathleen S. Montine, Thomas J. Montine, Adam M. Wawro, Mehrdad Shamloo, Chandresh R. Gajera
Publikováno v:
Journal of Neurochemistry. 158:1074-1082
Imbalance in the metabolic pathway linking excitatory and inhibitory neurotransmission has been implicated in multiple psychiatric and neurologic disorders. Recently, we described enantiomer-specific effects of 2-methylglutamate, which is not decarbo
Autor:
Caroline E. Bass, Megan Vik, Caitlin Szalkowski, Jinwoo Park, Ken T. Wakabayashi, Rohan V. Bhimani
Publikováno v:
J Neurochem
Methamphetamine (METH) is a potent psychostimulant that exerts many of its physiological and psychomotor effects by increasing extracellular dopamine (DA) concentrations in limbic brain regions. While several studies have focused on how potent, neuro
Autor:
Fernanda dos Santos Petry, J. Vladimir Oliveira, Aline E. dos Santos, Jefferson Pedroso, Sabrina Ester Schneider, Liz Girardi Müller, Marcelo Lanza, Cristiane Garbinato, Cássia Alves Lima-Rezende, Gean Pablo S. Aguiar, Anna Maria Siebel, Angelo Luis Stapassoli Piato
Publikováno v:
Neurochemical Research. 46:3025-3034
Epilepsy affects around 50 million people worldwide, and an important number of patients (30%) fail to respond to any available antiepileptic drug. Previous studies have shown that luteolin presents a promising potential as an anticonvulsant. On the
Autor:
Zhonghua Liu, Youlin Zeng, Peng Zhang, Yaqi Li, Songping Liang, Xinxin Zhao, Ying Wang, Saizhi Wu, Xiao He, Fengjiao Li
Publikováno v:
Journal of Medicinal Chemistry. 64:11483-11495
Glycosylation and fatty acid modification are promising strategies to improve peptide performance. We previously studied glycosylation and fatty acid modification of the anticancer peptide R-lycosin-I. In this study, we further investigated the co-mo
Autor:
Jing Wang, Jiaqi Liu, Lili Zhu, Rui Geng, Shuang Yang, Xiaoguang Yu, Jie Song, Tao Wang, Zhang Yang, Yanlong Han, Weimin Li, Lihong Wang
Publikováno v:
IUBMB Life. 73:1180-1190
The induction of ferroptosis is considered a new strategy for cancer treatment. Cytoplasmic polyadenylation element binding protein 1 (CPEB1) is a post-transcriptional regulatory factor, whose low expression has been reported to link to the enhanced
Autor:
Elfi B. Conemans, Alessandra D. Fisher, Suzanne M E Kuijpers, Chantal M. Wiepjes, Guy T'Sjoen, Martin den Heijer
Publikováno v:
Journal of Clinical Endocrinology and Metabolism, 106(10), E3936-E3945. The Endocrine Society
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
Kuijpers, S M E, Wiepjes, C M, Conemans, E B, Fisher, A D, Tsjoen, G & den Heijer, M 2021, ' Toward a Lowest Effective Dose of Cyproterone Acetate in Trans Women : Results from the ENIGI Study ', Journal of Clinical Endocrinology and Metabolism, vol. 106, no. 10, pp. E3936-E3945 . https://doi.org/10.1210/clinem/dgab427
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
Kuijpers, S M E, Wiepjes, C M, Conemans, E B, Fisher, A D, Tsjoen, G & den Heijer, M 2021, ' Toward a Lowest Effective Dose of Cyproterone Acetate in Trans Women : Results from the ENIGI Study ', Journal of Clinical Endocrinology and Metabolism, vol. 106, no. 10, pp. E3936-E3945 . https://doi.org/10.1210/clinem/dgab427
Context Cyproterone acetate (CPA) is a competitive inhibitor of the androgen receptor and exerts negative hypothalamic feedback. It is often used in combination with estrogens in trans women to achieve feminization. However, CPA has been associated w
Autor:
Caroline Hoffmann, Gregor Jung, Elmar Krause, Mark Bartholomae, Ina Hierlmeier, Stephan Maus, Tobias Stemler, Samer Ezziddin
Publikováno v:
Chemmedchem
The aim of this study was to identify a high‐affinity BODIPY peptidomimetic that targets the prostate‐specific membrane antigen (PSMA) as a potential bimodal imaging probe for prostate cancer. For the structure‐activity study, several BODIPY (d
Autor:
Tong-Cun Zhang, Chang Wang, Qing-Qing Dong, Rui Huang, Zhongyuan Li, Nan Wang, Wei Zhao, Yajian Song, Hai-Jie Hu, Xue-Gang Luo
Publikováno v:
Bioscience, Biotechnology, and Biochemistry. 85:1395-1404
Liraglutide is an analogue of human glucagon-like peptide-1 (GLP-1), an endogenous intestinal hormone which play essential roles in the regulation of glycolipid metabolism. To investigate the role of lactic acid bacteria (LAB) in the lipid-lowering e