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Publikováno v:
Journal of Proteome Research. 20:5036-5053
A suboptimal blood vitamin C (ascorbate) level increases the risk of several chronic diseases. However, the detection of hypovitaminosis C is not a simple task, as ascorbate is unstable in blood samples. In this study, we examined the serum proteome
Autor:
Kerry L. Hildreth, Kerrie L. Moreau, Robert S. Schwartz, Brian L. Stauffer, Wendy M. Kohrt, Matthew C. Babcock, Lyndsey E. DuBose, Teresa L. Witten
Publikováno v:
J Clin Endocrinol Metab
Context Vascular aging, including endothelial dysfunction secondary to oxidative stress and inflammation, increases the risk for age-associated cardiovascular disease (CVD). Low testosterone in middle-aged/older men is associated with increased CVD r
Autor:
Merve Acikel Elmas, Feriha Ercan, M. Kutay Köroğlu, Nesrin Kartal Ozer, Tugce Demirel-Yalciner, Erdi Sozen
Publikováno v:
IUBMB Life. 74:85-92
The seminiferous tubules where spermatogenesis occurs are enveloped and protected by the Sertoli cells to support germ cells undergoing meiosis to produce haploid gametes. Clearly, induction of apoptosis in seminiferous tubules leads to abnormalities
Autor:
In Jeoung Baek, Dae Won Jun, Brian Raught, Eun-Jung Jin, Chang Yeob Han, Jinsoo Song, Peter K. Kim, Sujeong Park, Kyu Yun Jang
Publikováno v:
Experimental & Molecular Medicine
In this study, we hypothesized that deregulation in the maintenance of the pool of coenzyme A (CoA) may play a crucial role in the pathogenesis of nonalcoholic fatty liver disease (NAFLD). Specific deletion of Acot12 (Acot12−/−), the major acyl-C
Autor:
Yaokun Li, Baoli Sun, Ming Deng, Guangbin Liu, Yao Liang, Dewu Liu, Hanchen Tian, Yongqing Guo
Publikováno v:
International Journal of Biological Macromolecules. 182:595-611
This study investigated the effects of Moringa oleifera polysaccharides (MOP) on the serum indexes, small intestinal morphology, small intestinal metabolic profile, and caecal microbiota of mice. A new type of polysaccharides with 104,031 Da molecula
Publikováno v:
Biological Trace Element Research. 200:1089-1094
Copper as an essential trace element is hypothesized to be involved in stroke risk. However, the evidence for associations between copper and stroke risk factors such as lipid levels has been mixed. This study aimed to examine the relationships betwe
Publikováno v:
Biochemical and Biophysical Research Communications. 553:1-8
Background and aims Hypercholesterolemia is characterized by the elevation of plasma total cholesterol level, especially low-density lipoprotein (LDL) cholesterol. This disease is usually caused by a mutation in genes such as LDL receptor, apolipopro
Autor:
M. Reza Azarpazhooh, Mitra Darbandi, Farid Najafi, Temilola Oduyemi, Soushyant Kiarasi, J. David Spence
Publikováno v:
Lipids. 56:405-412
High serum levels of triglycerides (Tg) and low levels of high-density lipoprotein cholesterol (HDL-C) are characteristic of the Metabolic Syndrome (MetS). We assessed the ratio of Tg to HDL-C as a way to identify MetS and insulin resistance. We also
Autor:
Tong-Cun Zhang, Chang Wang, Qing-Qing Dong, Rui Huang, Zhongyuan Li, Nan Wang, Wei Zhao, Yajian Song, Hai-Jie Hu, Xue-Gang Luo
Publikováno v:
Bioscience, Biotechnology, and Biochemistry. 85:1395-1404
Liraglutide is an analogue of human glucagon-like peptide-1 (GLP-1), an endogenous intestinal hormone which play essential roles in the regulation of glycolipid metabolism. To investigate the role of lactic acid bacteria (LAB) in the lipid-lowering e
Publikováno v:
The Journal of Biochemistry. 170:239-243
The translocator protein (TSPO) is a five-helix transmembrane protein localized to the outer mitochondria membrane. Radioligand binding assays and chemical crosslinking showed TSPO to be a high affinity cholesterol-binding protein. In this report, we