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Publikováno v:
Current Medicinal Chemistry. 28:2048-2061
Prostate cancer is the second most common cancer affecting the male population all over the world. The existence of a correlation between lipid metabolism disorders and cancer of the prostate gland has been widely known for a long time. According to
Autor:
Helena Trevisan Schroeder, Paulo Ivo Homem de Bittencourt, Juliane da Silva Rossato, Sofia Pizzato Scomazzon, Claudia Vieira Marques, Lucila Ludmila Paula Gutierrez, João Roberto Fernandes
Publikováno v:
Biochimie. 182:37-50
Disruption of the intracellular lipid balance leading to cholesterol accumulation is one of the features of cells that participate in the development of atherosclerotic lesions. Evidence form our laboratory indicates that anti-inflammatory cyclopente
Autor:
Marta Casado, Liya Pi, Wei Wei, Minjie Chen, Xicui Sun, Qi Cao, Paloma Martín-Sanz, Carme Cucarella, Bin Ren
Publikováno v:
Alcohol (Fayetteville, N.Y.)
Digital.CSIC. Repositorio Institucional del CSIC
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Digital.CSIC. Repositorio Institucional del CSIC
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12 páginas, 5 figuras, 2 tablas
Purpose: A diet high in fat and ethanol often results in chronic metabolic disorder, hepatic steatosis, and liver inflammation. Constitutive hepatic cyclooxygenase-2 (COX-2) expression could protect from high fat
Purpose: A diet high in fat and ethanol often results in chronic metabolic disorder, hepatic steatosis, and liver inflammation. Constitutive hepatic cyclooxygenase-2 (COX-2) expression could protect from high fat
Publikováno v:
Current Medical Science. 40:1099-1106
The effects of low ratio of n-6/n-3 polyunsaturated fatty acids (PUFA) have been clarified against atherosclerosis. Increasing evidence indicated that plant sterols (PS) have a significant cholesterol-lowering effect. This study explored the effects
Autor:
Benjamin M. Abraham, Felix Zhou, Edward A. Fisher, Johannes von Lintig, Ivan Pinos, Jaume Amengual, Tessa J. Barrett, Xiaoyun Wu
Publikováno v:
Journal of Lipid Research, Vol 61, Iss 11, Pp 1491-1503 (2020)
J Lipid Res
J Lipid Res
Atherosclerosis is characterized by the pathological accumulation of cholesterol-laden macrophages in the arterial wall. Atherosclerosis is also the main underlying cause of CVDs, and its development is largely driven by elevated plasma cholesterol.
Autor:
Aleksander Owczarek, Katarzyna Kokoszczyk, Armand Cholewka, Agata Stanek, Joanna Katarzyna Strzelczyk, Tomasz Wielkoszyński, Jolanta Zalejska-Fiolka
Publikováno v:
Oxidative Medicine and Cellular Longevity
Oxidative Medicine and Cellular Longevity, Vol 2020 (2020)
Oxidative Medicine and Cellular Longevity, Vol 2020 (2020)
Objective. Oxidized cholesterol derivatives are compounds with proven atherogenic and mutagenic effects. However, little is known about the effect of oxidized plant sterol derivatives (oxyphytosterols), whose structure is similar to the one of oxycho
Publikováno v:
Alcohol. 85:49-56
Cholesterol homeostasis has been proposed to be implicated in the development of addiction. However, the effects of ethanol on cholesterol homeostasis within the brain are not well understood. One of the most important regulators of cholesterol homeo
Autor:
Lei Cai, Stanley L. Hazen, Ibrahim Choucair, Ryan E. Temel, Naseer Sangwan, Jennifer A. Buffa, Amanda L. Brown, Robert N. Helsley, Camelia Baleanu Gogonea, J. Mark Brown, Jose C. Garcia-Garcia, Ina Nemet, Zeneng Wang, Preeti Pathak, Valentin Gogonea
Publikováno v:
Am J Physiol Heart Circ Physiol
The gut microbe-derived metabolite trimethylamine-N-oxide (TMAO) has recently been linked to cardiovascular disease (CVD) pathogenesis, prompting the development of therapeutic strategies to reduce TMAO. Previous work has shown that experimental alte
Autor:
Yajun Duan, Jialing Ma, Jiamin Su, Yali Yan, Lipei Liu, Jihong Han, Xiaoxiao Yang, Miao Yu, Peng Zeng, Jie Yang, Wenquan Hu, Yuanli Chen
Publikováno v:
Biochemical and Biophysical Research Communications. 524:439-445
Calorie restriction (CR) ameliorates various diseases including cardiovascular disease. However, its protection and underlying mechanisms against atherosclerosis remain un-fully elucidated. In this study, we fed apoE deficient (apoE-/-) mice in Contr
Autor:
Min Chen, Wen-Li Pan, Xu-Cong Lv, Pingfan Rao, Bin Liu, Li Ni, Jia-Xin Xu, Qing Zhang, Lu Li, Weidong Bai, Yan-Yan Zhang, Yi-Chen Lin, Wei-Ling Guo
Publikováno v:
International Journal of Biological Macromolecules. 145:1208-1218
Polysaccharide from Grifola frondosa is an excellent metal-ion chelating agent owing to its distinctive structure and outstanding functional activities. Our previous research has successfully synthesized novel organic chromium derived from the chelat