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Publikováno v:
Xenobiotica. 51:1292-1302
Zolmitriptan (ZOL), a member of triptans, has been used for the treatment of migraine with definite therapeutic effects. However, several cases of liver injury associated with ZOL have been reported and the underlying mechanisms remain unclear.The pr
Publikováno v:
Alcohol. 96:55-61
Alcohol abuse has become a serious health issue worldwide. Ketamine can reduce addiction risk among patients with alcohol use disorders. This study aimed to determine the effects of alcohol on the pharmacokinetics of ketamine during long-term alcohol
Publikováno v:
Xenobiotica. 51:1010-1018
Bovis Calculus Artifactus (BCA) is the main substitute for natural Calculus bovis, a traditional drug in China used to treat high fever, convulsion, and sore throat. The effect of BCA on cytochrome P450 (CYP) activities is unknown. This study was to
Autor:
Min Zhang, Wang Bin, Rui Yang, Li Jinliang, Zeng Fuqiang, Li Xuting, Li Sicong, Yuan Dingsheng
Publikováno v:
Xenobiotica. 51:961-967
Paeoniflorin is the major constituent in extracts of the paeony root, the purpose of the present study was to assess the effects of paeoniflorin on the activities and mRNA expression of the rat hepatic drug-metabolizing enzymes cytochrome P450 (CYP1A
Autor:
Surya Sandeep Mullapudi, Yamini Gullapalli, Sridhar Vemulapalli, Naveen Babu Kilaru, Vijaya R. Dirisala, Ravindra Babu Pingili
Publikováno v:
Xenobiotica. 51:926-932
The aim of the present study was to investigate the effect of naringenin (4,5,7-trihydroxy flavonone) on the pharmacokinetics of metoprolol, a substrate of Cytochrome P-450 3A4 (CYP3A4), CYP2C9, and CYP2D6 in rats. Male Wistar rats were treated orall
Autor:
Fabio García-García, Mario Eduardo Acosta-Hernández, Luis Angel López-Muciño, Sergio Priego-Fernández, Carolina Peña-Escudero
Publikováno v:
Alcohol. 93:63-70
The reduction of sleep hours is a public health problem in contemporary society. It is estimated that humans sleep between 1.5 and 2 h less, per night, than 100 years ago. The reduction of sleep hours is a risk factor for developing cardiovascular, m
Publikováno v:
Journal of Biochemical and Molecular Toxicology. 35:1-13
Cyclosporine-A (CsA) is a powerful immunosuppressive agent and hepatotoxicity results from CsA treatment. This study aimed to elucidate the effectiveness of tyrosine kinase inhibitor nilotinib against CsA-induced hepatotoxicity and the underlying mol
Autor:
Pankul Kotwal, Prashant Mishra, Anjna Sharma, S. B. Bhatt, Abhishek Gour, Priya Wazir, Priyanka Sharma, Utpal Nandi, Gurdarshan Singh, Ashish Dogra
Publikováno v:
Xenobiotica. 50:1332-1340
Diclofenac is an extensively used nonsteroidal anti-inflammatory drug, but gastrointestinal liabilities and cardiovascular complications take the shine away from such a widely prescribed drug. On the other hand, rutin, a dietary bioflavonoid, has qui
Autor:
Miroslav Styblo, Yuanyuan Li, Susan Sumner, Rowan Beck, Christelle Douillet, Madelyn C. Huang
Publikováno v:
Arch Toxicol
Inorganic arsenic (iAs) is an environmental diabetogen, but mechanisms underlying its diabetogenic effects are poorly understood. Exposures to arsenite (iAs(III)) and its methylated metabolites, methylarsonite (MAs(III)) and dimethylarsinite (DMAs(II
Autor:
Basit L Jan, Ajaz Ahmad, Mohammad A Alkharfy, Saeed Alqahtani, Fahad A Ali, Khalid M. Alkharfy, Mohammad Raish
Publikováno v:
Xenobiotica. 50:858-862
The current research explored the effect of hepatic and renal dysfunctions on the pharmacokinetics of thymoquinone (TQ) in a rat model.An acute kidney injury was induced using gentamicin and a liver damage was elicited using a single dose of d-galact