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Publikováno v:
The Journal of Clinical Endocrinology and Metabolism
Context The identification and biological actions of pituitary-derived exosomes remain elusive. Objective This work aimed to validate production of exosomes derived from human and rat pituitary and elucidate their actions. Methods Isolated extracellu
Autor:
Wilson I. Gonsalves, Larry M. Karnitz, Sadae Hitosugi, Kiran Kurmi, Taro Hitosugi, Annapoorna Sreedhar, Elizabeth K. Wiese, Yuan-Ping Pang, Lindsey G. Andres-Beck, Sharon T. Loa
Publikováno v:
Nature metabolism
Pharmacological activation of the glycolytic enzyme PKM2 or expression of the constitutively active PKM1 isoform in cancer cells results in decreased lactate production, a phenomenon known as the PKM2 paradox in the Warburg effect. Here we show that
Publikováno v:
Nature Metabolism. 3(2):131-141
Cancer cells reprogramme their metabolism to support unrestrained proliferation and survival in nutrient-poor conditions. Whereas non-transformed cells often have lower demands for serine and glycine, several cancer subtypes hyperactivate intracellul
Publikováno v:
Hormone and Metabolic Research. 53:63-70
MicroRNAs (miRNAs) are small, single-stranded, noncoding RNAs ~21 to ~23 nucleotides in length and have become a popular research topic in recent years due to their regulation of gene expression and many physiological processes, including fat metabol
Autor:
Teresa Zariñán, Rubén Gutiérrez-Sagal, Eduardo Jardón-Valadez, José L. Maravillas-Montero, Alfredo Ulloa-Aguirre, Julio Mayorga, Ma-del-Carmen Cravioto, Iván Martínez-Luis, Eric Reiter, Nancy R. Mejía-Domínguez, Omar G Yacini-Torres
Publikováno v:
Journal of Clinical Endocrinology and Metabolism
Journal of Clinical Endocrinology and Metabolism, Endocrine Society, 2020, 106 (2), pp.E534-E550. ⟨10.1210/clinem/dgaa782⟩
Journal of Clinical Endocrinology and Metabolism, 2021, 106 (2), pp.E534-E550. ⟨10.1210/clinem/dgaa782⟩
Journal of Clinical Endocrinology and Metabolism, Endocrine Society, 2020, 106 (2), pp.E534-E550. ⟨10.1210/clinem/dgaa782⟩
Journal of Clinical Endocrinology and Metabolism, 2021, 106 (2), pp.E534-E550. ⟨10.1210/clinem/dgaa782⟩
Context Follicle-stimulating hormone (FSH) plays an essential role in gonadal function. Loss-of-function mutations in the follicle-stimulating hormone receptor (FSHR) are an infrequent cause of primary ovarian failure. Objective To analyze the molecu
Autor:
Hua Dong, Wenfei Sun, Yang Shen, Miroslav Baláz, Lucia Balázová, Lianggong Ding, Mona Löffler, Bradford Hamilton, Nora Klöting, Matthias Blüher, Heike Neubauer, Holger Klein, Christian Wolfrum
Publikováno v:
Nature Metabolism
Nat. Metab. 4, 90–105 (2022)
Nature Metabolism, 4 (1)
Nat. Metab. 4, 90–105 (2022)
Nature Metabolism, 4 (1)
Healthy adipose tissue remodeling depends on the balance between de novo adipogenesis from adipogenic progenitor cells and the hypertrophy of adipocytes. De novo adipogenesis has been shown to promote healthy adipose tissue expansion, which confers p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::928a0b62b33cf32f952790cd50a377d2
Autor:
Jacob L. Jaremko, Jacqueline Halton, Conrad V. Fernandez, Khaldoun Koujok, Dcog-All, Nathalie Alos, Jinhui Ma, Josephine Ho, Ronald D. Barr, John Hay, Celia Rodd, Ronald Grant, Hester A. de Groot-Kruseman, Mariël L. te Winkel, Mary-Ann Matzinger, Stephanie A. Atkinson, Adam M. Huber, Robert de Jonge, Frank Rauch, Nazih Shenouda, Bianca Lang, Leanne M Ward, Emma J. Verwaaijen, Saskia M F Pluijm, Marry M. van den Heuvel-Eibrink, Rob Pieters, Inge M. van der Sluis, Jenneke E. van Atteveld, Annelies Hartman, Maarten H. Lequin
Publikováno v:
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 36(12), 2290-2299. Wiley-Blackwell
DCOG-ALL9 and Canadian STOPP Consortia 2021, ' A Validated Risk Prediction Model for Bone Fragility in Children With Acute Lymphoblastic Leukemia ', Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, vol. 36, no. 12, pp. 2290-2299 . https://doi.org/10.1002/jbmr.4442
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 36(12), 2290-2299
DCOG-ALL9 and Canadian STOPP Consortia 2021, ' A Validated Risk Prediction Model for Bone Fragility in Children With Acute Lymphoblastic Leukemia ', Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, vol. 36, no. 12, pp. 2290-2299 . https://doi.org/10.1002/jbmr.4442
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 36(12), 2290-2299
Introduction Due to bone fragility, children with acute lymphoblastic leukemia (ALL) have a 6-fold greater fracture risk during therapy compared to peers. Osteoporotic fractures are a concern, as they lead to adverse health outcomes including pain, l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::285adf5575a84709d0f3aa889d6d76d9
https://pure.eur.nl/en/publications/bdcd9b02-122e-45e0-b738-bcd4ec4d4f7d
https://pure.eur.nl/en/publications/bdcd9b02-122e-45e0-b738-bcd4ec4d4f7d
Autor:
Terry F. Davies, Syed A. Morshed
Publikováno v:
J Clin Endocrinol Metab
Understanding the regulatory mechanisms that control intracellular stress has fundamental importance since its failure results in cell death. Evidence has emerged indicating that the intracellular signals that are induced in response to diverse stres
Autor:
Francesco J. DeMayo, Thomas E. Spencer, San-Pin Wu, Steven L. Young, Tianyuan Wang, Ru-pin Alicia Chi, Nyssa Adams
Publikováno v:
J Clin Endocrinol Metab
Context Poor uterine receptivity is one major factor leading to pregnancy loss and infertility. Understanding the molecular events governing successful implantation is hence critical in combating infertility. Objective To define Progesterone Receptor
Autor:
Gerald V. Denis, Allison N Casey, Tova Meshulam, Yuhan Qiu, Manohar Kolla, Christina S Ennis, Nabil Rabhi, Jordan S. Shafran, Stephen R. Farmer, Carla Mazzeo, Naser Jafari, Isabella R Pompa
Publikováno v:
Sci Signal
Obesity and metabolic diseases, such as insulin resistance and type 2 diabetes (T2D), are associated with metastatic breast cancer in post-menopausal women. Here, we investigated the critical cellular and molecular factors behind this link. We found