Zobrazeno 1 - 10
of 21
pro vyhledávání: '"H Stacey"'
Serum bile acids as a sensitive biological marker for evaluating hepatic effects of organic solvents
Autor:
Neill H. Stacey, Masoud Neghab
Publikováno v:
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals. 5(2)
Serum bile acids (SBAs) are suggested as a potentially sensitive and specific indicator of liver function which, accordingly, could provide an early indication of hepatobiliary dysfunction. This offers advantages over more traditional parameters of l
Autor:
Neill H. Stacey, Samy A. Azer
Publikováno v:
Journal of Gastroenterology and Hepatology. 11:396-407
Hepatic sinusoidal uptake of bile acids is mediated by defined carrier proteins against unfavourable concentration and electrical gradients. Putative carrier proteins have been identified using bile acid photoaffinity labels and more recently using i
Publikováno v:
Hepatology. 11:750-756
Isolated rat hepatocytes have been advocated as a model to study aspects of mechanism of chemicalinduced interference with biliary excretory function. Some technical problems do exist in studying efflux, such as the reuptake of the previously excrete
Publikováno v:
Toxicology and Applied Pharmacology. 102:80-90
The effects of chlorinated aliphatic hydrocarbon solvent exposure on hepatocellular transport of some model substrates have been investigated. Exposure of isolated hepatocytes to 1,1,1-trichloroethane or tetrachloroethylene resulted in suppression of
Autor:
Samy A. Azer, Neill H. Stacey
Publikováno v:
Biochemical pharmacology. 42(10)
Autor:
Vicki Kefalas, Neill H. Stacey
Publikováno v:
Toxicology and applied pharmacology. 109(1)
A number of chemicals are known to potentiate the hepatotoxicity of carbon tetrachloride. The halocarbon trichloroethylene was shown in a previous study to enhance both carbon tetrachloride-induced toxicity and lipid peroxidation in isolated hepatocy
Autor:
Ludwig Müller, Neill H. Stacey
Publikováno v:
Biological Trace Element Research. 21:317-323
Effects of cadmium (Cd) in vivo and in vitro were studied in the absence of enhanced metallothionein (MT) production and overt Cd toxicity. Such a condition was established by extended oral exposure of male rats to 0.2 mumols Cd/kg and by incubation
Autor:
Neill H. Stacey
Publikováno v:
Immunopharmacology. 8:155-161
Ethanol has been shown to inhibit spontaneous cell-mediated cytotoxicity and antibody-dependent cell-mediated cytotoxicity in vitro in a dose-dependent manner. The effect was observed under differing assay conditions such as incubation time and effec
Publikováno v:
Carcinogenesis. 10:2119-2122
The mutagenic properties of Ethacure 300, Cyanacure and Polacure 740M, all possible substitutes for the industrial carcinogen, 4,4'-methylene bis(2-chloroaniline), have been determined in Salmonella typhimurium strains TA100, TA98, TA1535 and TA1537.
Publikováno v:
Biochemical Pharmacology. 37:4177-4181
Propiconazole, a foliar fungicide used for agricultural purposes was studied for its effects on the hepatic xenobiotic biotransformation in the rat. Rats were given an intraperitoneal injection of 0.1, 1, 10 or 100 mg/kg in corn oil for seven consecu