Zobrazeno 1 - 10
of 374
pro vyhledávání: '"35"'
Publikováno v:
Journal of Virology. 78:6715-6722
The D,DX 35 E motif characteristic of retroviral integrase enzymes (INs) is expected to bind the required metal cofactors (Mg 2+ or Mn 2+ ), but direct evidence for a catalytic role has been lacking. Here we used a metal rescue strategy to investigat
Autor:
Vaniambadi S. Kalyanaraman, Alagarsamy Srinivasan, Derhsing Lai, Brian Tomkowicz, Maria Cartas, Sundarasamy Mahalingam, Satya P. Singh, Ramachandran Murali
Publikováno v:
Journal of Virology. 74:10650-10657
Members of the lentivirus family of retroviruses have been shown to contain nonstructural proteins of viral origin in addition to the structural proteins in the virus particles, a feature noted with several DNA viruses (10, 15, 21, 27). Specifically,
Publikováno v:
Comparative Biochemistry and Physiology Part C: Comparative Pharmacology. 102:385-389
1. Larvae of yellow mealworm ( Tenebrio molitor L.), European rhinoceros beetle ( Oryctes nasicornis L.), garden chafer ( Phyllopertha horticola L.) and summer chafer ( Amphimallon solstitiale ) were kept in semi-natural substrates which had been mix
Publikováno v:
Cytokine. 76:70
We created peptides that protect broadly against severe, life-threatening infections and reveal a novel and critical regulatory role for costimulatory receptor homodimer interfaces in inflammatory T-cell hyperactivation. Our finding is that the inter
Publikováno v:
Journal of Virology. 49:142-153
We report on the properties of a genetically and immunologically related family of structural (gamma) polypeptides of herpes simplex virus 1 designated as infected cell polypeptides (ICP) 35. The members of this family were identified and studied wit
Publikováno v:
Transfusion. 21:219-223
DHA (dihydroxyacetone, 60 mM) with ascorbic acid (d-ascorbate, 10 mM) kept 2,3-DPG concentrations above normal for six weeks. Levels of 2,3-DPG were below normal after four weeks with DHA alone and after two weeks with DHA-ascorbate-phosphate. As in
Autor:
Aleksander Koj, Jerzy Silberring, Anna Bierczyńska-Krzysik, Emilia Bonar, Adam Dubin, Marek J. Noga, Krystyna Stalińska
Publikováno v:
Cytokine. 33(2)
Interleukin-1 (IL-1) and interleukin-6 (IL-6) are principal proinflammatory cytokines inducing the acute phase response of various tissues, including liver. Cultured human hepatoma HepG2 cells were stimulated with IL-1 (10 ng/ml) and IL-6 (10 ng/ml).
Autor:
Naveen Arora, Vikram K Jain, Shakuntala Lavasa, Bharti Arora, Swati Sharma, Shailendra Nath Gaur
Publikováno v:
Molecular Immunology. 137:84-93
Background Prosopis juliflora is a clinically relevant allergic sensitizer worldwide and shares cross-reactivity with allergens from several tree pollen and food. The present study aims to purify and immunobiochemically characterize a major allergen
Autor:
Ian W. Flinn, Jason C. Paik, Tian Tian, Tadeusz Robak, Emmanuelle Ferrant, Alessandra Tedeschi, Jennifer R. Brown, Jane Huang, Vanitha Ramakrishnan, Constantine S. Tam, Aileen Cohen, Peter Hillmen, Paolo Ghia, Sowmya B. Kuwahara
Publikováno v:
Blood. 138:67-67
Background: Zanubrutinib is a selective next-generation Bruton tyrosine kinase (BTK) inhibitor designed to have high specificity for BTK and minimize off-target effects (J Med Chem 2019;62:7923-40). Data from several phase 2 CLL trials assessing BCL-
Autor:
Mariela Sivina, William G. Wierda, Andreas Rosenwald, Michael J. Keating, Ekaterina Kim, Elena Hartmann, Alessandra Ferrajoli, Alicia Vaca, Jan A. Burger, Gordon S. Duncan, Takashi Sakamoto, Tak W. Mak
Publikováno v:
Blood. 134:5448-5448
Background: Toso, the FcR receptor (FcmR) for IgM, is a type I transmembrane protein belonging to the immunoglobulin gene superfamily. Toso is expressed in lymphocytes, and plays an important role in B cell development and survival. In normal B cells