Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Hiroyuki Miyachi"'
Publikováno v:
Acta crystallographica. Section F, Structural biology communications. 78(Pt 2)
Peroxisome proliferator-activated receptor δ (PPARδ) is a member of the nuclear receptor family and regulates glucose and lipid homeostasis in a ligand-dependent manner. Numerous phenylpropanoic acid derivatives targeting three PPAR subtypes (PPAR
Autor:
Hiroyuki Miyachi
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 9223, p 9223 (2021)
International Journal of Molecular Sciences, Vol 22, Iss 9223, p 9223 (2021)
Progress in understanding peroxisome proliferator-activated receptor (PPAR) subtypes as nuclear receptors that have pleiotropic effects on biological responses has enabled the exploration of new subtype-selective PPAR ligands. Such ligands are useful
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 25:2639-2644
We designed and synthesized acylsulfonamide derivative (3) as a human peroxisome proliferator-activated receptor gamma (hPPARγ) partial agonist by structural modification of hPPARγ full agonist 1. Co-crystallization of 3 with hPPARγ LBD afforded a
Autor:
Masao Ohashi, Naoyuki Kuwabara, Hiroyuki Miyachi, Toshiyuki Shimizu, Daisuke Tomioka, Takuji Oyama, Junn Yanagisawa
Publikováno v:
Journal of Medicinal Chemistry. 55:893-902
Human peroxisome proliferator-activated receptors (hPPARs) are ligand-dependent transcription factors that control various biological responses, and there are three subtypes: hPPARα, hPPARδ, and hPPARγ. We report here that α-substituted phenylpro
Autor:
Shuichi Hirono, Izumi Nakagome, Yoshino Nishio, Kosuke Morikawa, Takuji Oyama, Yuichi Hashimoto, Mayumi Satoh, Hiromi Nobusada, Masao Ohashi, Hiroyuki Miyachi
Publikováno v:
Journal of Medicinal Chemistry. 54:331-341
Peroxisome proliferator-activated receptor gamma (PPARγ) is a ligand-mediated transcription factor with roles in glucose, lipid, and lipoprotein homeostasis, and PPARγ ligands are expected have therapeutic potential in these as well as other areas.
Autor:
Tomomi Noguchi-Yachide, Yusuke Mita, Minoru Ishikawa, Hiroyuki Miyachi, Yuichi Hashimoto, Kosuke Dodo, Makoto Makishima
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:1712-1717
Suppression of vitamin D receptor (VDR)-mediated transcription is expected be of therapeutic value in Paget's disease. Once an agonist activates VDR, recruitment of additional coactivator proteins is essential for transcription. Neither non-secostero
Publikováno v:
Bioorganicmedicinal chemistry letters. 25(14)
In the course of studies directed toward the creation of human peroxisome proliferator-activated receptor gamma (hPPARγ) partial agonists, we designed and synthesized benzylsulfonylaminocarbonyl derivative (3) by structural modification of our repor
Autor:
Kazuo Nagasawa, Shinnosuke Hosoda, Yuichi Hashimoto, Makoto Makishima, Ken-ichi Wakabayashi, Keisuke Imai, Hiroyuki Miyachi, Aya Tanatani
Publikováno v:
Bioorganic & Medicinal Chemistry. 14:5489-5502
Ligands possessing dual vitamin D 3 (VD 3 )-agonistic and androgen–antagonistic activities with various activity spectra were prepared based on a substituted 3,3-diphenylpentane (DPP) skeleton. Among the compounds, ( R , S )-DPP-1023 [( R , S )- 7b
Publikováno v:
Chemicalpharmaceutical bulletin. 62(5)
Hesperidin, a flavanone glycoside present abundantly in citrus fruits, is predominantly metabolized to hesperetin-7-O-β-D-glucuronide (H7-OG) and hesperetin-3'-O-β-D-glucuronide (H3'-OG), which exhibit partial agonistic activity towards peroxisome
Publikováno v:
Bioorganicmedicinal chemistry letters. 23(6)
We designed a series of pyrazole-based carboxylic acids as candidate ligands of heart fatty acid binding protein (H-FABP, or FABP3), based on a comparison of the X-ray crystallographic structures of adipocyte fatty acid binding protein (FABP4)-select