Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Mark P. Foster"'
Publikováno v:
Biochemistry
Allostery pervades macromolecular function and drives cooperative binding of ligands to macromolecules. To decipher the mechanisms of cooperative ligand binding it is necessary to define, at a microscopic level, the thermodynamic consequences of bind
Mechanistic Models Fit to Variable Temperature Calorimetric Data Provide Insights into Cooperativity
Publikováno v:
Biophysical Journal. 112:1328-1338
Allostery pervades macromolecular function and drives cooperative binding of ligands to macromolecules. To decipher the mechanisms of cooperative ligand binding it is necessary to define at a microscopic level the structural and thermodynamic consequ
Publikováno v:
Nucleic Acids Research
The RNA-binding protein L7Ae, known for its role in translation (as part of ribosomes) and RNA modification (as part of sn/oRNPs), has also been identified as a subunit of archaeal RNase P, a ribonucleoprotein complex that employs an RNA catalyst for
Autor:
Alexandra B. Kuzmishin, Oscar Vargas-Rodriguez, Ronald Micura, Kotaro Nakanishi, Xiao Ma, Yuki Goto, Eric M. Danhart, Karin Musier-Forsyth, Mark P. Foster, Marina Bakhtina, Marija Košutić, Brianne L. Sanford, William A. Cantara, Hiroaki Suga
Publikováno v:
Proceedings of the National Academy of Sciences. 114
Molecular sieves ensure proper pairing of tRNAs and amino acids during aminoacyl-tRNA biosynthesis, thereby avoiding detrimental effects of mistranslation on cell growth and viability. Mischarging errors are often corrected through the activity of sp
Publikováno v:
Protein Science. 11:1850-1853
Identifying potential ligand binding sites on a protein surface is an important first step for targeted structure-based drug discovery. While performing control experiments with Escherichia coli peptide deformylase (PDF), we noted that the organic so
Publikováno v:
Journal of Virology. 82:4363-4370
Replication of picornaviral genomes requires recognition of at least three cis -acting replication elements: oriL, oriI, and oriR. Although these elements lack an obvious consensus sequence or structure, they are all recognized by the virus-encoded 3
Publikováno v:
Journal of Molecular Biology. 370:303-314
Site-specific recombinases of the lambda-integrase family recognize and cleave their cognate DNA sites through cooperative binding to opposite sides of the DNA substrate by a C-terminal catalytic domain and a flexibly linked "core-binding" domain; re
Autor:
Mark P. Foster, Steven J. McBryant, Ben Gedulin, Anne Leresche, Peter E. Wright, Paul J. Romaniuk, Joel M. Gottesfeld, Nik Veldhoen
Publikováno v:
Journal of Molecular Biology. 248:44-57
Zinc fingers 4 to 7 of Xenopus transcription factor IIIA (TFIIIA) represent the minimal polypeptide necessary for high-affinity binding to 5 S RNA. Mutations covering the entire 5 S RNA structure have been compared for their effects on the binding af
Publikováno v:
Journal of molecular biology. 415(2)
The trp RNA-binding attenuation protein (TRAP) is a paradigmatic allosteric protein that regulates the tryptophan biosynthetic genes associated with the trp operon in Bacilli. The ring-shaped 11-mer TRAP is activated for recognition of a specific trp