Zobrazeno 1 - 10
of 480
pro vyhledávání: ''
Publikováno v:
Biochemistry. 56:1836-1840
Designing subtype-selective agonists for neuronal nicotinic acetylcholine receptors (nACh¬R) is a challenging and significant goal aided by intricate knowledge of each subtype’s binding patterns. We previously reported that in α6β2 receptors, ac
Autor:
Ozlem Keskin, Serena Muratcioglu, Michael Kilcooley, John R. Pooley, Ayse Derya Cavga, Attila Gursoy, Caroline A Rivers, Susana N. Paul, Stafford L. Lightman, YM Kershaw
Publikováno v:
PLoS ONE, Vol 15, Iss 1, p e0227520 (2020)
Pooley, J, Rivers, C A, Kilcooley, M, Paul, S N, Cavga, A D, Kershaw, Y M, Muratcioglu, S, Gursoy, A, Keskin, O & Lightman, S L 2020, ' Beyond the heterodimer model for mineralocorticoid and glucocorticoid receptor interactions in nuclei and at DNA. ', PLoS ONE, vol. 15, no. 1, e0227520 . https://doi.org/10.1371/journal.pone.0227520
PLOS One
PLoS ONE
Pooley, J, Rivers, C A, Kilcooley, M, Paul, S N, Cavga, A D, Kershaw, Y M, Muratcioglu, S, Gursoy, A, Keskin, O & Lightman, S L 2020, ' Beyond the heterodimer model for mineralocorticoid and glucocorticoid receptor interactions in nuclei and at DNA. ', PLoS ONE, vol. 15, no. 1, e0227520 . https://doi.org/10.1371/journal.pone.0227520
PLOS One
PLoS ONE
Glucocorticoid (GR) and mineralocorticoid receptors (MR) are believed to classically bind DNA as homodimers or MR-GR heterodimers to influence gene regulation in response to pulsatile basal or stress-evoked glucocorticoid secretion. Pulsed corticoste
Autor:
Hyunil Jo, William F. DeGrado, Yoga Srinivasan, David E. Shaw, Ron O. Dror, Shaun R. Coughlin, Michael Grabe, James R. Valcourt, Albert C. Pan, Michael P. Bokoch, Sara Capponi
Publikováno v:
Biochemistry, vol 57, iss 39
The pathways that G protein-coupled receptor (GPCR) ligands follow as they bind to or dissociate from their receptors are largely unknown. Protease-activated receptor-1 (PAR1) is a GPCR activated by intramolecular binding of a tethered agonist peptid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9cc10f18aa91a77f699cf29f1b515a0
https://europepmc.org/articles/PMC6584023/
https://europepmc.org/articles/PMC6584023/
Autor:
Stephen W. Doughty, Meyyammai Swaminathan, Noorsaadah Abd Rahman, Michael J. C. Buckle, Chin Fei Chee, Lip Yong Chung, Sek Peng Chin
Publikováno v:
Molecules, Vol 19, Iss 7, Pp 8933-8948 (2014)
Molecules; Volume 19; Issue 7; Pages: 8933-8948
Molecules
Molecules; Volume 19; Issue 7; Pages: 8933-8948
Molecules
Muscarinic acetylcholine receptor-active compounds have potential for the treatment of Alzheimer’s disease. In this study, a series of natural and synthetic flavones and flavonols was assayed in vitro for their ability to inhibit radioligand bindin
Autor:
John E. Baker, Gabriella A. Kartz, Jidong Su, Joshua J. Ziarek, Christopher T. Veldkamp, Fuming Zhang, Brian F. Volkman, Nathan J. Murray, Robert J. Linhardt, Xinle Liang
Publikováno v:
Journal of Biological Chemistry. 288:737-746
The ability to interact with cell surface glycosaminoglycans (GAGs) is essential to the cell migration properties of chemokines, but association with soluble GAGs induces the oligomerization of most chemokines including CXCL12. Monomeric CXCL12, but
Autor:
Zhong-Ze Fang, Fuyi Wang, Liang-Liang Zhu, Wenbing Hu, Jie Hou, Guang-Bo Ge, Guiyuan He, Chun-Zhi Ai, Si-Cheng Liang, Ling Yang
Publikováno v:
European Journal of Pharmaceutical Sciences. 48:360-369
Boc5, the first nonpeptidic agonist of Glucagon-like peptide-1 receptor, has been recognized as a potential candidate for treatment of diabetes. However, the metabolic behaviors of this novel molecule in both human and experimental animals remain unc
Publikováno v:
Current Medicinal Chemistry. 19:3044-3057
Tryptamine (T) and several T derivatives (Ts) inhibit in a voltage-dependent manner the NMDA receptor (NR). This effect is influenced by substituents at various positions, but has not yet been subjected to a detailed SAR study. Here, 64 Ts have been
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 335:600-606
Alcohols and inhaled anesthetics enhance the function of GABA(A) receptors containing α, β, and γ subunits. Molecular analysis has focused on the role of the α subunits; however, there is evidence that the β subunits may also be important. The g
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:4284-4287
At the GABA(A) receptor, low concentrations of etomidate potentiate the inhibitory effect of GABA on specific binding of the closed channel ligand [(3)H]ethynylpropylbicycloorthobenzoate ([(3)H]EBOB). Here, we present SARs for etomidate and structura
Autor:
Katie M. Vance, John R. Hepler, Matthew T. Geballe, Chian-Ming Low, Manuel Yepes, Hongjie Yuan, Candice E. Junge, James P. Snyder, Stephen F. Traynelis
Publikováno v:
Journal of Biological Chemistry. 284:12862-12873
Zinc is hypothesized to be co-released with glutamate at synapses of the central nervous system. Zinc binds to NR1/NR2A N-methyl-d-aspartate (NMDA) receptors with high affinity and inhibits NMDAR function in a voltage-independent manner. The serine p