Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Vivien R. Sutton"'
Autor:
Joseph A. Trapani, Vivien R. Sutton
Publikováno v:
Current Opinion in Immunology. 15:533-543
Granzyme B is a caspase-like serine protease that is released by cytotoxic lymphocytes to kill virus-infected and tumor cells. Major recent advances in our understanding of granzyme B biochemistry, biology and function include an appreciation of its
Publikováno v:
Immunity. 18:319-329
Apoptosis in response to granzyme B involves activation of caspase-dependent target cell death pathways. Herein, we show that granzyme B initiates caspase processing but cannot fully process procaspase-3 in intact Jurkat T leukemia or NT2 neuronal ce
Autor:
Kevin Y. T. Thia, Vivien R. Sutton, Joseph A. Trapani, Phillip I. Bird, Michael J. Pinkoski, Ricky W. Johnstone, Karin A Sedelies, Nigel J. Waterhouse, Green Dr
Publikováno v:
Cell death and differentiation. 13(4)
Loss of Bid confers clonogenic survival to granzyme B-treated cells, however the exact role of Bid-induced mitochondrial damage--upstream or downstream of caspases--remains controversial. Here we show that direct cleavage of Bid by granzyme B, but no
Autor:
Michelle E Wowk, Kylie A. Browne, Christopher J.P. Clarke, Phillip I. Bird, Vivien R. Sutton, Karin A Sedelies, Jane Oliaro, Joseph A. Trapani, Ricky W. Johnstone, Nigel J. Waterhouse, Ralph K. Lindemann, Andrea Newbold
Publikováno v:
The Journal of biological chemistry. 280(6)
Granzyme B, a protease released from cytotoxic lymphocytes, has been proposed to induce target cell death by cleaving and activating the pro-apoptotic Bcl-2 family member Bid. It has also been proposed that granzyme B can induce target cell death by
Autor:
Mark J. Smyth, Reinhard Kofler, Vivien R. Sutton, Kellie M. Tainton, Michael J. Ausserlechner, Ricky W. Johnstone, David Bernhard, Astrid A. Ruefli
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 98(19)
Many chemotherapeutic agents induce mitochondrial-membrane disruption to initiate apoptosis. However, the upstream events leading to drug-induced mitochondrial perturbation have remained poorly defined. We have used a variety of physiological and pha
Autor:
Karin A Sedelies, Joseph A. Trapani, Kylie A. Browne, Joanne E. Davis, Astrid A. Ruefli, Ricky W. Johnstone, Michael Cancilla, Vivien R. Sutton
Publikováno v:
The Journal of Experimental Medicine
The essential upstream steps in granzyme B–mediated apoptosis remain undefined. Herein, we show that granzyme B triggers the mitochondrial apoptotic pathway through direct cleavage of Bid; however, cleavage of procaspases was stalled when mitochond
Autor:
Joseph A. Trapani, Karin A Sedelies, Nigel J. Waterhouse, Phillip I. Bird, Ricky W. Johnstone, Ruth M. Kluck, Vivien R. Sutton, Melinda E. Christensen, Grant Dewson
Publikováno v:
Cell Death & Disease
Overexpression of Bcl-2 contributes to resistance of cancer cells to human cytotoxic lymphocytes (CL) by blocking granzyme B (GraB)-induced mitochondrial outer membrane permeabilization (MOMP). Drugs that neutralise Bcl-2 (e.g., ABT-737) may therefor