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Publikováno v:
Alcohol. 96:55-61
Alcohol abuse has become a serious health issue worldwide. Ketamine can reduce addiction risk among patients with alcohol use disorders. This study aimed to determine the effects of alcohol on the pharmacokinetics of ketamine during long-term alcohol
Autor:
Fabio García-García, Mario Eduardo Acosta-Hernández, Luis Angel López-Muciño, Sergio Priego-Fernández, Carolina Peña-Escudero
Publikováno v:
Alcohol. 93:63-70
The reduction of sleep hours is a public health problem in contemporary society. It is estimated that humans sleep between 1.5 and 2 h less, per night, than 100 years ago. The reduction of sleep hours is a risk factor for developing cardiovascular, m
Autor:
Stefany Sousa Alves, Luciana Marangni Nolli, Marcus Vinicius von Zuben, Eloisa Dutra Caldas, Márcia Renata Mortari, Aline Pic-Taylor, Danilo Gustavo Rodrigues de Oliveira
Publikováno v:
Alcohol. 84:67-75
Ayahuasca is a hallucinogenic infusion used in religious rituals that has serotoninergic properties and may be a potential therapeutic option for drug addiction. In this study, Wistar rats had intermittent access to ethanol for 8 weeks, receiving wat
Autor:
Petr K. Anokhin, Olga Y. Frolova, Maria V. Belopolskaya, Vsevolod V. Pavshintsev, Ekaterina A. Kushnir, Maxim L. Lovat, Nikita A. Mitkin
Publikováno v:
Alcohol. 83:17-28
Chronic ethanol consumption in high doses is associated with constitutively elevated activity of the serum alcohol dehydrogenase I (ADH I) isoform, which demonstrates a high affinity not only for ethanol but also for a number of bioamine metabolites.
Autor:
Paula T. Tonin, Jair C. Soares, João Quevedo, Fernanda F. Gava, Gustavo C. Dal-Pont, Samira S. Valvassori, Roger B. Varela, Camila Ferreira, Monica L. Andersen
Publikováno v:
Pharmacology Biochemistry and Behavior. 183:56-63
The present study evaluated the effects of the coadministration of lithium (Li) and Cel on inflammatory parameters in an animal model of mania induced by dextroamphetamine (D-amph). It was used Wistar rats 60 days old (250–350 g). The animals (n =
Publikováno v:
Pharmacology Biochemistry and Behavior. 183:64-71
Addiction to the psychostimulant Methamphetamine (METH) is characterised by high rates of relapse. Currently there are no approved effective pharmacotherapies for METH dependence. The neuropeptide oxytocin (OXY) potently reduces METH-seeking behaviou
Publikováno v:
Pharmacol Biochem Behav
This study analyzed whether the positive allosteric modulator of metabotropic glutamate receptor type 5 (mGlu5) 3-Cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl) benzamide (CDPPB) would alleviate deficits in prepulse inhibition (PPI) and affect dopamine (DA)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6822689f97def7b414d731b72396426b
https://europepmc.org/articles/PMC9176413/
https://europepmc.org/articles/PMC9176413/
Publikováno v:
Pharmacol Biochem Behav
Over the past two decades, opioid abuse has risen especially among women. In both sexes hippocampal neural circuits involved in associative memory formation and encoding of motivational incentives are critically important in the transition from initi
Autor:
Kristin Ataras, Michael M. Morgan
Publikováno v:
Pharmacol Biochem Behav
Opioids such as morphine are the most effective treatment for pain, but termination of opioid use can produce severe withdrawal symptoms. The present study models this process by using home cage wheel running to assess well-being as a result of pain,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bae32a853df15649ca3c5ed6d8979b05
https://europepmc.org/articles/PMC8429200/
https://europepmc.org/articles/PMC8429200/
Autor:
Kenji Hashimoto, Yukihiko Shirayama, Tomihisa Niitsu, Nobuhisa Kanahara, Yuki Hirose, Yasunori Oda, Hiroshi Kimura, Masaomi Iyo, Kouhei Yoshino, Makoto Kimura
Publikováno v:
Pharmacology, biochemistry, and behavior. 211
Background The excessive blockade of dopamine D2 receptors (DRD2s) with long-term antipsychotic treatment is known to induce a dopamine supersensitivity state (DSS). The mechanism of DSS is speculated to be a compensatory up-regulation of DRD2s, but