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Publikováno v:
Pharmacology, biochemistry, and behavior. 209
Neuronal adaptations involving dopaminergic, glutamatergic, and serotonergic neurotransmitter systems are responsible for behavioral sensitization. Because of common underlying mechanisms, cross-sensitization between compounds of different drug class
Publikováno v:
Pharmacology, biochemistry, and behavior. 211
Alcohol abuse is a widespread cause of aggressive and impulsive behaviors that impact the users as well as their entourage. However, only a few medications are effective. Recently, cannabidiol has been reported to improve mood disorders and recovery
Autor:
Paula T. Tonin, Jair C. Soares, João Quevedo, Fernanda F. Gava, Gustavo C. Dal-Pont, Samira S. Valvassori, Roger B. Varela, Camila Ferreira, Monica L. Andersen
Publikováno v:
Pharmacology Biochemistry and Behavior. 183:56-63
The present study evaluated the effects of the coadministration of lithium (Li) and Cel on inflammatory parameters in an animal model of mania induced by dextroamphetamine (D-amph). It was used Wistar rats 60 days old (250–350 g). The animals (n =
Publikováno v:
Pharmacology Biochemistry and Behavior. 183:64-71
Addiction to the psychostimulant Methamphetamine (METH) is characterised by high rates of relapse. Currently there are no approved effective pharmacotherapies for METH dependence. The neuropeptide oxytocin (OXY) potently reduces METH-seeking behaviou
Publikováno v:
Alcohol. 77:79-89
Methylphenidate (MPD) is a psychostimulant used to treat attention deficit hyperactivity disorder (ADHD). Most adult ADHD patients use ethanol in combination with MPD. This research examined the effects of MPD and ethanol on flash-evoked potentials (
Autor:
Marisela Hernández-González, Tania Molina-Jiménez, Rossana C. Zepeda, Malinalli Brianza-Padilla, Herlinda Bonilla-Jaime, Martín Jiménez-Tlapa
Publikováno v:
Pharmacology Biochemistry and Behavior. 180:83-91
Administering clomipramine during the early days of life induced several behavioral and neurochemical alterations in adult male rats, which resemble major depression disorder. The alterations included poor sexual performance, which is considered a re
Publikováno v:
Pharmacol Biochem Behav
Serotonin 5-HT(2A) receptors are expressed throughout the mesolimbic and mesocortical dopamine pathways, and manipulation of this receptor system has a profound impact on dopamine functions and dopamine-mediated behaviors. It is highly likely that 5-
Autor:
Jacob T. Krug, Matthew S. Mayes, Kathy Ayala, Aaron Ettenberg, Adam K. Klein, Erin M. Purvis, Lisette Collins, Matthew P. A. Fisher
Publikováno v:
Pharmacology Biochemistry and Behavior. 179:150-155
Bipolar illness is characterized by periods of “mania” — high energy, irritability, and increased psychomotor activation. While the neurobiological investigation of mania has been limited by the lack of reliable animal models, researchers have
Autor:
Yingxian Xiao, Amir H. Rezvani, Edward D. Levin, Corinne Wells, Kenneth J. Kellar, Susan Slade
Publikováno v:
Pharmacology Biochemistry and Behavior. 179:109-112
Sazetidine-A selectively desensitizes α4β2 nicotinic receptors and also has partial agonist effects. We have shown that subcutaneous acute and repeated injections as well as chronic infusions of sazetidine-A significantly reduce intravenous (IV) ni
Autor:
Joseph P. Huston, Maria A. de Souza Silva, Christina Antke, Anja Müller-Lutz, Markus Beu, Hans-Jörg Wittsack, Hans-Wilhelm Müller, Hubertus Hautzel, Susanne Nikolaus, Frithjof Wickrath, Gerald Antoch
Publikováno v:
Pharmacology Biochemistry and Behavior. 179:156-170
Purpose The present study assessed the influence of the NMDA receptor (R) antagonist amantadine (AMA) on cerebral dopamine D2/3R binding in relation to motor and exploratory activity in the rat. Methods D2/3R binding was determined in anaesthetized a