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Autor:
Verónica Sanchez, Xavier Nadal, Ximena López Hill, Cecilia Scorza, Jessika Urbanavicius, José Pedro Prieto
Publikováno v:
Neurotoxicity Research. 38:478-486
In the last years, clinical and preclinical researchers have increased their interest in non-psychotomimetic cannabinoids, like cannabidiol (CBD), as a strategy for treating psychostimulant use disorders. However, there are discrepancies in the pharm
Autor:
Darshini Desai, Manoj Govindarajulu, Timothy Moore, Edwin McElroy, Satyanarayana R. Pondugula, Eddie Fahoury, Mohammed Almaghrabi, Rishi Nadar, Kristina Gill, Kodye L. Abbott, Muralikrishnan Dhanasekaran, Sindhu Ramesh, Mohammed Majrashi, Natasha Narayanan
Publikováno v:
Toxicology Mechanisms and Methods. 30:454-461
Endogenous (hyperglycemia) and exogenous (therapeutic, prophylactic, street drugs) factors can considerably contribute to cognitive impairment (CI). Currently, there are few invasive and/or noninvasive markers that correlate with CI and those that do
Publikováno v:
NeuroToxicology. 74:264-271
Ingestion of the noncompetitive GABAA receptor antagonist tetramethylenedisulfotetramine (TETS) results in arrhythmias, respiratory depression, and life-threatening convulsive status epilepticus. We have previously developed a realistic model of volu
Autor:
Paula T. Tonin, Jair C. Soares, João Quevedo, Fernanda F. Gava, Gustavo C. Dal-Pont, Samira S. Valvassori, Roger B. Varela, Camila Ferreira, Monica L. Andersen
Publikováno v:
Pharmacology Biochemistry and Behavior. 183:56-63
The present study evaluated the effects of the coadministration of lithium (Li) and Cel on inflammatory parameters in an animal model of mania induced by dextroamphetamine (D-amph). It was used Wistar rats 60 days old (250–350 g). The animals (n =
Publikováno v:
Chemico-Biological Interactions. 308:279-287
The dose-dependent neuroprotective role of licorice-derived glycyrrhizin during subacute neuroterminal norepinephrine (NE) depletion was studied in rat brain. Experimental design included thirty 5-week-old male rats randomly divided into five groups.
Publikováno v:
Pharmacol Biochem Behav
This study analyzed whether the positive allosteric modulator of metabotropic glutamate receptor type 5 (mGlu5) 3-Cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl) benzamide (CDPPB) would alleviate deficits in prepulse inhibition (PPI) and affect dopamine (DA)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6822689f97def7b414d731b72396426b
https://europepmc.org/articles/PMC9176413/
https://europepmc.org/articles/PMC9176413/
Autor:
Kristin Ataras, Michael M. Morgan
Publikováno v:
Pharmacol Biochem Behav
Opioids such as morphine are the most effective treatment for pain, but termination of opioid use can produce severe withdrawal symptoms. The present study models this process by using home cage wheel running to assess well-being as a result of pain,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bae32a853df15649ca3c5ed6d8979b05
https://europepmc.org/articles/PMC8429200/
https://europepmc.org/articles/PMC8429200/
Autor:
Shaimaa Kamel, Ahmed M. Hussien, Ashraf M. Morgan, Fatimah A. M. Al-Zahrani, Mona K. Galal, Marwa A. Ibrahim, Eman I. Hassanen, Hanan A. Ogaly, Maha M. Rashad, Sharah A. Al Dulmani
Publikováno v:
Journal of biochemical and molecular toxicologyREFERENCES. 35(10)
Penconazole (PEN) is a widely used systemic fungicide to treat various fungal diseases in plants but it leaves residues in crops and food products causing serious environmental and health problems. N-acetylcysteine (NAC) is a precursor of the antioxi
Publikováno v:
Basicclinical pharmacologytoxicologyREFERENCES. 129(6)
Peripheral neurotoxicity is a dose-limiting and a potentially lifelong persistent toxicity of cisplatin. This study investigated the possible protective effect of Piceatannol (PIC) in a model of cisplatin-induced peripheral neuropathy in rats. PIC (1
Autor:
Anni Fan, Mengmeng Wang, Nanxi Bi, Ruiqing Zhou, Xiaozhen Gu, Hui-Li Wang, Quan-Cai Sun, Danyang Li
Publikováno v:
Toxicology. 465
Bisphenol-A (BPA), an environmental endocrine disruptor, is toxic to the central nervous system. Although recent studies have shown BPA-induced neurotoxicity, it is far from clear what precisely epigenetic mechanisms are involved in BPA-induced cogni