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Publikováno v:
Pharmacology, biochemistry, and behavior. 209
Neuronal adaptations involving dopaminergic, glutamatergic, and serotonergic neurotransmitter systems are responsible for behavioral sensitization. Because of common underlying mechanisms, cross-sensitization between compounds of different drug class
Publikováno v:
Pharmacology, biochemistry, and behavior. 211
Alcohol abuse is a widespread cause of aggressive and impulsive behaviors that impact the users as well as their entourage. However, only a few medications are effective. Recently, cannabidiol has been reported to improve mood disorders and recovery
Autor:
Paula T. Tonin, Jair C. Soares, João Quevedo, Fernanda F. Gava, Gustavo C. Dal-Pont, Samira S. Valvassori, Roger B. Varela, Camila Ferreira, Monica L. Andersen
Publikováno v:
Pharmacology Biochemistry and Behavior. 183:56-63
The present study evaluated the effects of the coadministration of lithium (Li) and Cel on inflammatory parameters in an animal model of mania induced by dextroamphetamine (D-amph). It was used Wistar rats 60 days old (250–350 g). The animals (n =
Publikováno v:
Chemico-Biological Interactions. 308:279-287
The dose-dependent neuroprotective role of licorice-derived glycyrrhizin during subacute neuroterminal norepinephrine (NE) depletion was studied in rat brain. Experimental design included thirty 5-week-old male rats randomly divided into five groups.
Autor:
Hannah White, Marty Cauley, Zachary Spiera, Leah Yao, Edward D. Levin, Shaqif Junaid, Andrew B. Hawkey
Publikováno v:
Birth Defects Res
Tobacco smoke is a complex mixture that includes thousands of compounds. Previously, we have found that gestational exposure to the complex mixture of tobacco smoke extract caused long-term neurobehavioral impairments. In this study, we examined the
Publikováno v:
Pharmacol Biochem Behav
Serotonin 5-HT(2A) receptors are expressed throughout the mesolimbic and mesocortical dopamine pathways, and manipulation of this receptor system has a profound impact on dopamine functions and dopamine-mediated behaviors. It is highly likely that 5-
Autor:
Jacob T. Krug, Matthew S. Mayes, Kathy Ayala, Aaron Ettenberg, Adam K. Klein, Erin M. Purvis, Lisette Collins, Matthew P. A. Fisher
Publikováno v:
Pharmacology Biochemistry and Behavior. 179:150-155
Bipolar illness is characterized by periods of “mania” — high energy, irritability, and increased psychomotor activation. While the neurobiological investigation of mania has been limited by the lack of reliable animal models, researchers have
Publikováno v:
Pharmacology Biochemistry and Behavior. 179:142-149
Parkinson's disease (PD) is a neurodegenerative disorder, which is characterized by microglia activation and dopaminergic neurons affected by inflammatory processes. Inflammation has been recognized to be necessary for initiation and progress of PD.
Publikováno v:
Food and Chemical Toxicology. 125:170-181
Clinical and experimental data have demonstrated that diabetes is associated with neurological complications. Protocatechuic acid (PCA) is a phenolic phytochemical widely reported to possess antidiabetic property. However, there is no scientific info
Publikováno v:
Neurotoxicology and Teratology. 71:32-40
Exposure to organophosphate (OP) compounds leads to behavioral alterations. To determine whether paraoxon has effects on anxiety, anxiety-like behaviors were assessed in paraoxon-exposed rats. Protein expression of glutamate transporters has also bee