Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Paul R. Race"'
Autor:
Ashley J. Winter, Matthew T. Rowe, Angus N. M. Weir, Nahida Akter, Sbusisiwe Z. Mbatha, Paul D. Walker, Christopher Williams, Zhongshu Song, Paul R. Race, Christine L. Willis, Matthew P. Crump
Publikováno v:
Winter, A J, Rowe, M T, Weir, A N M, Akter, N, Mbatha, S Z, Walker, P D, Williams, C, Song, Z, Race, P R, Willis, C L & Crump, M P 2022, ' Programmed Iteration Controls the Assembly of the Nonanoic Acid Side Chain of the Antibiotic Mupirocin ', Angewandte Chemie-International Edition, vol. 61, no. 50, e202212393 . https://doi.org/10.1002/anie.202212393
Mupirocin is a clinically important antibiotic produced by Pseudomonas fluorescens NCIMB 10586 that is assembled by a complex trans-AT polyketide synthase. The polyketide fragment, monic acid, is esterified by a 9-hydroxynonanoic acid (9HN) side chai
Autor:
Nahida Akter, Matthew T. Rowe, Ashley J. Winter, Christine L. Willis, Christopher Williams, Matthew P. Crump, Thomas J. Simpson, Paul R. Race, Zhongshu Song, Angus N M Weir, Luoyi Wang, Paul D. Walker
Publikováno v:
Walker, P D, Rowe, M T, Winter, A J, Weir, A N M, Akter, N, Wang, L, Race, P R, Williams, C, Song, Z, Simpson, T J, Willis, C L & Crump, M P 2020, ' A Priming Cassette Generates Hydroxylated Acyl Starter Units in Mupirocin and Thiomarinol Biosynthesis ', ACS Chemical Biology, vol. 2020 . https://doi.org/10.1021/acschembio.9b00969
Mupirocin, a commercially available antibiotic produced by Pseudomonas fluorescens NCIMB 10586, and thiomarinol, isolated from the marine bacterium Pseudoalteromonas sp. SANK 73390, both consist of a polyketide-derived monic acid homologue esterified
Autor:
Li-Chen Han, Matthew J. Byrne, James E. M. Stach, Carl O. Marsh, Nicholas R. Lees, Phillip W. Duke, Laurence Maschio, Sebastian Pagden‐Ratcliffe, Paul R. Race, Paul Curnow, Christine L. Willis, Sbusisiwe Z. Mbatha
Publikováno v:
Marsh, C O, Lees, N R, Han, L-C, Byrne, M J, Mbatha, S Z, Maschio, L, Pagden-Ratcliffe, S, Duke, P, Stach, J E M, Curnow, P, Willis, C L & Race, P R 2019, ' A Natural Diels-Alder Biocatalyst Enables Efficient [4 + 2] Cycloaddition Under Harsh Reaction Conditions ', ChemCatChem . https://doi.org/10.1002/cctc.201901285
Carbon‐carbon bond formation is a fundamental transformation in both synthetic chemistry and biosynthesis. Enzymes catalyze such reactions with exquisite selectivity which often cannot be achieved using non‐biological methods but may suffer from
Control of β‐Branching in Kalimantacin Biosynthesis: Application of13C NMR to Polyketide Programming
Autor:
John Crosby, Luoyi Wang, Thomas J. Simpson, Angus N M Weir, Christopher Williams, Paul R. Race, Paul D. Walker, Christine L. Willis, Matthew P. Crump
Publikováno v:
Walker, P, Williams, C, Weir, A, Wang, L, Crosby, J, Race, P, Simpson, T, Willis, C & Crump, M 2019, ' Control of beta-Branching in Kalimantacin Biosynthesis : Application of 13C NMR to Polyketide Programming ', Angewandte Chemie, vol. 131, no. 36, pp. 12576-12580 . https://doi.org/10.1002/ange.201905482
The presence of beta‐branches in the structure of polyketides that possess potent biological activity underpins their widespread importance. Kalimantacin is a polyketide antibiotic with selective activity against staphylococci and its biosynthesis
Autor:
Jonathan A. Davies, Marisa Till, Thomas D. Ackrill, Alice Robson, Christine L. Willis, Paul R. Race, Kavita Tiwari, Catherine R. Back, Matthew J. Byrne, Asha V. Nair
Publikováno v:
Nair, A V, Robson, A, Ackrill, T D, Till, M, Byrne, M J, Back, C, Tiwari, K, Davies, J, Willis, C L & Race, P R 2020, ' Structure and mechanism of a dehydratase/decarboxylase enzyme couple involved in polyketide β-methyl branch incorporation ', Scientific Reports, vol. 10 (2020), 15323 . https://doi.org/10.1038/s41598-020-71850-w
Scientific Reports, Vol 10, Iss 1, Pp 1-16 (2020)
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-16 (2020)
Scientific Reports
Complex polyketides of bacterial origin are biosynthesised by giant assembly-line like megaenzymes of the type 1 modular polyketide synthase (PKS) class. The trans-AT family of modular PKSs, whose biosynthetic frameworks diverge significantly from th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2dbbc44c86bc1a39ec33f8a583dea41
https://research-information.bris.ac.uk/en/publications/2740573e-9c26-441d-a581-c7abbcbe1641
https://research-information.bris.ac.uk/en/publications/2740573e-9c26-441d-a581-c7abbcbe1641
Autor:
Christine L. Willis, Jonathan A. Davies, Freya M. Bull, Joleen Masschelein, Angus N M Weir, Thomas J. Simpson, Matthew P. Crump, Paul D. Walker, Rob Lavigne, Paul R. Race
Publikováno v:
Davies, J A, Bull, F M, Walker, P D, Weir, A N M, Lavigne, R, Masschelein, J, Simpson, T J, Race, P R, Crump, M P & Willis, C L 2020, ' Total Synthesis of Kalimantacin A ', Organic Letters, vol. 22, no. 16, pp. 6349-6353 . https://doi.org/10.1021/acs.orglett.0c02190
The kalimantacins make up a family of hybrid polyketide-nonribosomal peptide-derived natural products that display potent and selective antibiotic activity against multidrug resistant strains of Staphylococcus aureus. Herein, we report the first tota
Autor:
Matthew P. Crump, Zhongshu Song, Paul R. Race, Freya M. Bull, Joleen Masschelein, Luoyi Wang, Chengsen Cui, Thomas J. Simpson, Rob Lavigne, Shu-Shan Gao, Iain R. G. Thistlethwaite, Paul D. Walker, Christine L. Willis
Publikováno v:
Thistlethwaite, I, Bull, F, Cui, C, Walker, P, Gao, S-S, Wang, L, Song, Z, Masschelein, J, Lavigne, R, Crump, M, Race, P, Simpson, T & Willis, C 2017, ' Elucidation of the relative and absolute stereochemistry of the kalimantacin/batumin antibiotics ', Chemical Science, vol. 8, no. 9, pp. 6196-6201 . https://doi.org/10.1039/c7sc01670k
Kalimantacin A and batumin exhibit potent and selective antibiotic activity against Staphylococcus species including MRSA. Both compounds are formed via a hybrid polyketide synthase/non-ribosomal peptide synthetase (PKS-NRPS) biosynthetic pathway and
Autor:
James E. M. Stach, Nicholas R. Lees, Jonathan A. Davies, Matthew J. Byrne, Marc W. van der Kamp, Alice E. Parnell, Christine L. Willis, Paul R. Race, Pollyanna E. J. Moreland, Li-Chen Han
Publikováno v:
Lees, N R, Han, L-C, Byrne, M, Davies, J, Parnell, A, Moreland, P, Stach, J E M, Van der Kamp, M, Willis, C & Race, P 2019, ' An Esterase-like Lyase Catalyzes Acetate Elimination in Spirotetronate/Spirotetramate Biosynthesis ', Angewandte Chemie-International Edition, vol. 58, no. 8, pp. 2305-2309 . https://doi.org/10.1002/anie.201812105
Spirotetronate and spirotetramate natural products include a multitude of compounds with potent antimicrobial and antitumor activities. Their biosynthesis incorporates many unusual biocatalytic steps, including regio- and stereo-specific modification
Autor:
Marc W. van der Kamp, Nicholas R. Lees, Li-Chen Han, Adrian J. Mulholland, James E. M. Stach, Christine L. Willis, Paul R. Race, Matthew J. Byrne
Publikováno v:
Byrne, M J, Lees, N R, Han, L C, Van Der Kamp, M W, Mulholland, A J, Stach, J E M, Willis, C L & Race, P R 2016, ' The Catalytic Mechanism of a Natural Diels-Alderase Revealed in Molecular Detail ', Journal of the American Chemical Society, vol. 138, no. 19, pp. 6095-6098 . https://doi.org/10.1021/jacs.6b00232
The Diels-Alder reaction, a [4 + 2] cycloaddition of a conjugated diene to a dienophile, is one of the most powerful reactions in synthetic chemistry. Biocatalysts capable of unlocking new and efficient Diels-Alder reactions would have major impact.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6617f4ca019f9d599e3f7b2d254fbf06
https://research-information.bris.ac.uk/en/publications/32041429-4e5a-4df8-944b-47b2dedb65f5
https://research-information.bris.ac.uk/en/publications/32041429-4e5a-4df8-944b-47b2dedb65f5