Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Xindong Liu"'
Autor:
Lilin Ye, Xinyuan Zhou, Zhunyi Xie, Zhenyu Liu, Shupei Tang, Yi Cao, Xindong Liu, Yanyan Guo, Xiaoping Wu, Chunji Huang, Yuzhang Wu, Lan Zhou, Dongwei Meng, Haiyang He, Huang Huang
Publikováno v:
The Journal of Immunology. 203:323-327
The differentiation of memory CD8+ T cells is critical to the long-term cellular immunity. The transcription factor BCL6 has been reportedly important for the generation and maintenance of memory CD8+ T cells; however, using the newly established BCL
Publikováno v:
Immunity. 54:2740-2755.e6
Summary T follicular helper (Tfh) cells play essential roles in regulating humoral immunity, especially germinal center reactions. However, how CD4+ T cells integrate the antigenic and costimulatory signals in Tfh cell development is still poorly und
Autor:
Chen Dong, Xia Zhang, Xiaofeng Wen, Tingting Chen, Kalyan C. Nallaparaju, Shinya Tanaka, Qiang Tian, Huiping Lu, Wei Jin, Xiu-Wu Bian, Xiaowei Yan, Li Zhang, Lai Wei, Xindong Liu, Kenji Ichiyama
Publikováno v:
Cell Reports. 14:1735-1747
SummaryT follicular helper (Tfh) cell is a unique T cell subset specialized in promoting humoral immunity. B-cell lymphoma 6 protein (Bcl6) has been identified as an obligatory transcription factor in Tfh cells; however, the molecular mechanism under
Autor:
Han Feng, Xindong Liu, Xiaoshuang Wang, Wei Xu, Chen Dong, Wei Jin, Xiaohong Zhao, Mengting Gou, Xiaohu Wang
Publikováno v:
Immunity. 51:826-839.e5
T follicular helper (Tfh) cells provide essential help to B cells in germinal center (GC) reactions. Bcl6 is the obligatory lineage transcription factor in Tfh cells. Here, we examined the molecular pathways that induce Bcl6 gene expression and under
Autor:
Hiroko Nakatsukasa, Sattva S. Neelapu, Bo Zhong, Xindong Liu, Fuliang Chu, Aibo Wang, Roza Nurieva, Lai Wei, Chen Dong, Laurens G. van der Flier, Wanjun Chen, Xiaowei Yan, Ping Chen, Hai Qi, Xiaohu Wang, Xin Chen, Hans Clevers, Qiang Tian
Publikováno v:
Nature
Nature, 507(7493), 513-8. Nature Publishing Group
Nature, 507(7493), 513-8. Nature Publishing Group
In immune responses, activated T cells migrate to B-cell follicles and develop into follicular T-helper (TFH) cells, a recently identified subset of CD4(+) T cells specialized in providing help to B lymphocytes in the induction of germinal centres. A
Publikováno v:
Immunological reviews. 252(1)
T-follicular helper (Tfh) cells are a new subset of effector CD4(+) T cells that are specialized in helping B cells in the germinal center reaction. Tfh cells are distinct from other established CD4(+) T-cell lineages, Th1, Th2, Th17, and T-regulator
Autor:
Xiaohu Wang, Enric Esplugues, Seon Hee Chang, Yi-Hong Wang, Roza Nurieva, Xiaowei Yan, Aibo Wang, Xindong Liu, Chen Dong, Bo Zhong, Natalia Martin-Orozco, Qiang Tian, Richard A. Flavell
Publikováno v:
The Journal of Experimental Medicine
A novel Bcl6 reporter mouse is used to dissect the developmental requirements, plasticity, and genetic profile of Tfh cells.
T follicular helper cells (Tfh cells) play a pivotal role in germinal center reactions, which require B cell lymphoma 6
T follicular helper cells (Tfh cells) play a pivotal role in germinal center reactions, which require B cell lymphoma 6
Autor:
Bruce R. Blazar, Jun Qi, James E. Bradner, Joseph H. Antin, Katelyn Goodman, Corey Cutler, Ryan Flynn, Ari Melnick, Ivan Maillard, Leo Luznik, Kelli P. A. MacDonald, Angela Panoskaltsis-Mortari, Zhang Yi, Xindong Liu, Jerome Ritz, William J. Murphy, Jonathan S. Serody, Chen Dong, John Koreth, Geoffrey R. Hill, Du Jing, Robert J. Soiffer
Publikováno v:
Blood. 124:535-535
To study transcriptional pathways and develop targeted therapeutics for cGVHD, we studied the effects of emerging therapeutic agents targeting GCs. BCL6 is a master regulatory transcription factor, which facilitates GC development in a cooperative ma