Zobrazeno 1 - 10
of 414
pro vyhledávání: '"11"'
Publikováno v:
PLoS ONE
PLoS ONE, Vol 15, Iss 1, p e0227180 (2020)
PLOS ONE
PLoS ONE, Vol 15, Iss 1, p e0227180 (2020)
PLOS ONE
Recent evidence shows that the disruption of constitutive insulated neighbourhoods might lead to oncogene dysregulation. We present here a systematic pan-cancer characterisation of the associations between constitutive boundaries and genome alteratio
Decomposing the subclonal structure of tumors with two-way mixture models on copy number aberrations
Publikováno v:
PLoS ONE
PLoS ONE, Vol 13, Iss 12, p e0206579 (2018)
PLoS ONE, Vol 13, Iss 12, p e0206579 (2018)
Multistage tumorigenesis is a dynamic process characterized by the accumulation of mutations. Thus, a tumor mass is composed of genetically divergent cell subclones. With the advancement of next-generation sequencing (NGS), mathematical models have b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c7f850b26d57deb8b1050493f8abb11
https://doi.org/10.1101/278887
https://doi.org/10.1101/278887
Publikováno v:
PLoS ONE, Vol 11, Iss 10, p e0164870 (2016)
PLoS ONE
PLoS ONE
Amplification of 11q13.3 is a frequent event in human cancers, including head and neck squamous cell carcinoma. This chromosome region contains several genes that are potentially cancer drivers, including FADD (Fas associated via death domain), an ap
Publikováno v:
PLoS ONE
PLoS ONE, Vol 9, Iss 4, p e95210 (2014)
PLoS ONE, Vol 9, Iss 4, p e95210 (2014)
Aberrant changes in the expression of the pro-apoptotic protein, BCL-2-like 11 (BIM), can result in either impaired or excessive apoptosis, which can contribute to tumorigenesis and degenerative disorders, respectively. Altering BIM pre-mRNA splicing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa181ee905b8a80299fe439b2f138a8e
https://hdl.handle.net/10356/104198
https://hdl.handle.net/10356/104198
Autor:
Yongzhan Nie, Shanhong Tang, Jie Liu, Kaichun Wu, Zheng Chen, Jie Ding, Guanghui Xu, Rui Fan, Lin Xia, Jiang Jin, Rui Du, Qian Bi, Liucun Gao, Shuhui Liang, Yongquan Shi, Daiming Fan
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e40169 (2012)
PLoS ONE
PLoS ONE
Background Studies have been shown that miR-125a plays an important role in carcinogenesis, however, the role of miR-125a in hepatocellular carcinoma (HCC) remains elusive. Methodology/Principal Real time-PCR (qRT-PCR) was performed to test the signi
Autor:
Laura Marín, Luis O. González, Francisco J. Vizoso, Lucía González, Salomé González-Reyes, Maria L. Lamelas, Belen Fernandez-Garcia, Noemi Eiro, José M. del Casar
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e49047 (2012)
PLoS ONE
PLoS ONE
Inflammatory conditions may promote tumor progression and aggressiveness. In previous reports, we found a group of breast cancer tumors characterized by metalloprotease-11 (MMP-11) expression by intratumoral mononuclear inflammatory cells (MICs), whi
Autor:
Fernande René-Corail, Abir Al Ghuzlan, Marine Guillaud-Bataille, Yves Le Bouc, Johann Guillemot, Eric Clauser, Eric Baudin, Olivia Barreau, Marthe Rizk-Rabin, Isabelle Francillard, Jérôme Bertherat, Guillaume Assié, Aurélien de Reyniès, Claire Chevalier, Virginie Steunou, Bruno Ragazzon, Xavier Bertagna, Frédérique Tissier
Publikováno v:
PLoS ONE
PLoS ONE, Public Library of Science, 2014, 9 (8), pp.e103744. ⟨10.1371/journal.pone.0103744⟩
PLoS ONE, 2014, 9 (8), pp.e103744. ⟨10.1371/journal.pone.0103744⟩
PLoS ONE, Public Library of Science, 2014, 9 (8), pp.e103744. 〈10.1371/journal.pone.0103744〉
PLoS ONE, Vol 9, Iss 8, p e103744 (2014)
PLoS ONE, Public Library of Science, 2014, 9 (8), pp.e103744. ⟨10.1371/journal.pone.0103744⟩
PLoS ONE, 2014, 9 (8), pp.e103744. ⟨10.1371/journal.pone.0103744⟩
PLoS ONE, Public Library of Science, 2014, 9 (8), pp.e103744. 〈10.1371/journal.pone.0103744〉
PLoS ONE, Vol 9, Iss 8, p e103744 (2014)
International audience; Insulin-like growth factor 2 (IGF2) overexpression is an important molecular marker of adrenocortical carcinoma (ACC), which is a rare but devastating endocrine cancer. It is not clear whether IGF2 overexpression modifies the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad9eb05d6bd3e092f4191302dc96ebdf
https://hal.archives-ouvertes.fr/hal-02376096
https://hal.archives-ouvertes.fr/hal-02376096
Autor:
Hannah Breit, Benjamin Kefas, Christel Herold-Mende, Anindya Dutta, Kaitlyn Marks, Roger Abounader, Michael Synowitz, Desiree Floyd, Rainer Glass, Ying Zhang, Bijan K. Dey, Benjamin Purow
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e96239 (2014)
PLoS ONE
PLoS ONE
Glioblastoma is the most common and lethal primary brain tumor. Tumor initiation and recurrence are likely caused by a sub-population of glioblastoma stem cells, which may derive from mutated neural stem and precursor cells. Since CD133 is a stem cel
Autor:
Yang Li, Jun Li, Longgang Wei, Yingpu Tian, Wenjie Liu, Xiandong Lin, Gen-Sheng Feng, Baozhen Chen, Zhongxian Lu, Yujia Kang
Publikováno v:
PLoS ONE, Vol 9, Iss 7, p e102847 (2014)
PLoS ONE
PLoS ONE
The extranuclear estrogen receptor pathway opens up novel perspectives in many physiological and pathological processes, especially in breast carcinogenesis. However, its function and mechanisms are not fully understood. Herein we present data identi
Autor:
Sha Fu, Jian Yong Shao, Mu Sheng Zeng, Yi Xin Zeng, Yang Yang Li, Hai Yun Wang, Xiao Pai Wang, Zi Chen Zhang
Publikováno v:
PLoS ONE
PLoS ONE, Vol 9, Iss 1, p e86149 (2014)
PLoS ONE, Vol 9, Iss 1, p e86149 (2014)
MicroRNA-214 (MiR-214) is aberrantly expressed in several human tumors such as ovarian cancer and breast cancer. However, the role of miR-214 in nasopharyngeal carcinoma (NPC) is still unknown. In this study, we report that miR-214 was overexpressed