Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Shyam S. Chauhan"'
Publikováno v:
Molecular and Cellular Biochemistry. 322:119-125
In this study, we demonstrate that pGEM-4Z can be used as a mammalian expression vector. Western blotting and Immunocytochemical analyses revealed that transfection of pGEM-4Z-containing human cathepsin L cDNA under T-7 but not under SP-6 promoter in
Publikováno v:
Gene. 399:129-136
The role of vascular endothelial growth factor (VEGF) on cathepsin L expression was investigated in human glioblastoma cells (U87MG). Our results demonstrate the transcriptional upregulation of cathepsin L expression by VEGF. Transient transfection o
Autor:
Shivani Arora, Shyam S. Chauhan
Publikováno v:
Gene. 293:123-131
Human cathepsin L (hCATL) has been implicated in a variety of physiological and pathological processes. It was hitherto known to be encoded by four mRNA species, namely hCATL A, AI, AII and hCATL B, differing in their 5' untranslated regions (UTRs).
Autor:
Digamber Behera, Vikas Kumar Verma, Sangeeta Sharma, Vishnubhatla Sreenivas, Shyam S. Chauhan, H. K. Prasad, Anand Jaiswal, Vibha Taneja
Publikováno v:
PLoS ONE
PLoS ONE, Vol 7, Iss 4, p e34355 (2012)
PLoS ONE, Vol 7, Iss 4, p e34355 (2012)
Cytokine/cytokine receptor gene polymorphisms related to structure/expression could impact immune response. Hence, the -237 polymorphic site in the 5' promoter region of the IL-12Rβ2 (SNP ID: rs11810249) gene associated with the AP-4 transcription m
Publikováno v:
Biological chemistry. 392(5)
The expression of cathepsin L, a lysosomal protease, is known to be elevated in cancer and other pathologies. Multiple splice variants of human cathepsin L with variable 5′UTRs exist, which encode for the same protein. Previously we have observed t
Publikováno v:
The FEBS journal. 277(8)
Dipetidyl-peptidase III is a metallopeptidase involved in a number of physiological processes and its expression has been reported to increase with the histological aggressiveness of human ovarian primary carcinomas. Because no information regarding
Autor:
Shyam S. Chauhan, Michael M. Gottesman
Publikováno v:
Gene. 120:281-285
We describe here the construction of a vector (pSSC-9) which can be used for the insertional mutagenesis of any gene for which genomic sequences have been cloned. This vector contains a neomycin-resistance-encoding gene (neoR) which is driven by a mo
Publikováno v:
Gene. 321
Cathepsin L is a lysosomal cysteine protease over-expressed in malignancy. It is very potent in degrading collagen, elastin, laminin and other components of the basement membrane and therefore, has been implicated in tumor invasion and metastasis. Tw
Publikováno v:
Gene. 275(1)
Cathepsin L is a lysosomal cysteine protease, which is over-expressed and secreted by malignant cells. It is very potent in degrading collagen, elastin, laminin and other components of the basement membrane and, therefore, has been implicated in tumo
Publikováno v:
Biochemistry. 37(23)
Cathepsin L, a lysosomal cysteine protease, is overexpressed and secreted by malignantly transformed cells. However, the reason for secretion of this man 6-phosphate-containing lysosomal protease into the extracellular medium is not clear. We wished