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Autor:
Stephen L. Atkin, Amirhossein Sahebkar, Parvin Zamani, Jamshid Gholizadeh Navashenaq, Reza Kazemi Oskuee
Publikováno v:
Progress in Biophysics and Molecular Biology. 150:50-61
Inflammasomes are a group of cytosolic multi-protein signaling complexes that regulate maturation of the interleukin (IL)-1 family cytokines IL-1β and IL-18 through activation of inflammatory caspase-1. The NOD-like receptor family, pyrin domain con
Lnc-SNHG1 may promote the progression of non-small cell lung cancer by acting as a sponge of miR-497
Publikováno v:
Biochemical and Biophysical Research Communications. 506:632-640
Lnc-SNHG1 (small nucleolar RNA host gene 1) is considered an important regulating factor in several types of cancers. However, the biological functions and underlying molecular mechanisms in which lnc-SNHG1 is involved in non-small cell lung cancer (
Autor:
Yonghwan Shin, Seulki Choi, Eun Namkoong, Seunghee Cha, Jong-Ho Lee, Minkyoung Kim, Se-Young Choi, Kyungpyo Park, Nahyun Kim
Publikováno v:
Biochemical and Biophysical Research Communications. 466:704-710
Purinergic receptors, particularly type 7 (P2RX7), are involved in apoptotic cell death. However, the expression and function of P2RX7 are suppressed in HSG cells. In the present study, we explored whether P2RX7 function is regulated by epigenetic al
Autor:
Masaya Sato, Motoyuki Otsuka, Takeshi Yoshikawa, Kazuhiko Koike, Takahiro Kishikawa, Motoko Ohno
Publikováno v:
Biochemical and Biophysical Research Communications. 465:764-768
Immune cells, such as natural killer (NK) cells, recognize virally infected and transformed cells, and eliminate them through the interaction between NKG2D receptors on NK cells and NKG2D ligands on pathogenic cells. Shedding of NKG2D ligands is thou
Publikováno v:
Biochimica et biophysica acta. Gene regulatory mechanisms. 1861(3)
miR-1275 is one of the microRNAs (miRNAs) that are differentially expressed during follicular atresia in pig ovaries, as identified by a miRNA microarray assay in our previous study [1]. However, its functions in follicular atresia remain unknown. In
Publikováno v:
Biochemical and Biophysical Research Communications. 463:853-858
Succinate acts as an extracellular signaling molecule as well as an intermediate in the citric acid cycle. It binds to and activates its specific G protein-coupled receptor 91 (GPR91). GPR91 is present in hepatic stellate cells (HSCs), but its role i
Autor:
Jung Hwan Yu, Hyeonjin Choi, Jo Woon Seok, Yoo Jeong Lee, Yoon Jeong Choi, Jae Woo Kim, Hyo Jung Kim
Publikováno v:
Biochemical and Biophysical Research Communications. 460:715-720
Monoacylglycerol O-acyltransferase (MGAT) is an enzyme that is involved in triglyceride synthesis by catalyzing the formation of diacylglycerol from monoacylglycerol and fatty acyl CoAs. Recently, we reported that MGAT1 has a critical role in hepatic
Publikováno v:
FEBS Letters. 589:756-765
MicroRNAs (miRNAs) play a critical role in the development of cancers. However, the role of miRNAs in glioma is still poorly understood. In this study, we demonstrate that microRNA-10a (miR-10a) promotes cell migration and invasion by negatively regu
Autor:
Alberto Papi, Gaetano Caramori, Chao Meng, Stephen J. Wort, Marc Humbert, Ian M. Adcock, Peter Dormuller, David J. Welsh, Paolo Casolari, Frédéric Perros, Andrew J. Peacock, Pai Chien Chou, Colin Church, Dongmin Shao
Publikováno v:
Biochemical and Biophysical Research Communications. 451:8-14
Idiopathic pulmonary arterial hypertension (IPAH) is an incurable condition leading to right ventricular failure and death and inflammation is postulated to be associated with vascular remodelling. Interleukin (IL)-33, a member of the "alarmin" famil
Publikováno v:
Biochemical and Biophysical Research Communications. 450:1547-1552
High mobility group box 1 protein (HMGB1) is a chromatin protein which can be released extracellularly, eliciting a pro-inflammatory response and promoting tissue repair process. This study aimed to examine the expression and distribution of HMGB1 an