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Publikováno v:
Cell Cycle
Acute myeloid leukemia (AML) is a common hematopoietic malignancy with a generally poor prognosis. Long non-coding RNA (lncRNA) urothelial carcinoma-associated 1 (UCA1) has been identified as an oncogene in various malignancies including AML. However
Publikováno v:
DNA and Cell Biology. 39:615-630
Uterine corpus endometrial carcinoma (UCEC) is one of the leading causes of death from gynecological cancer due to the high recurrence rate. A recent study indicated that molecular biomarkers can enhance the recurrence prediction power if they were i
Publikováno v:
ChemBioChem. 21:1022-1027
Live-cell sensing of telomerase activity with simple and efficient strategies remains a challenging target. In this work, a strategy for telomerase sensing by using hybridization-sensitive fluorescent oligonucleotide probes is reported. In the presen
Autor:
Andreas R. Janecke, Georg F. Vogel, Thomas Müller, Katharina M.C. Klee, Lukas A. Huber, Peter Heinz-Erian, Štefan Rosipal, Hasret Ayyıldız Civan
Publikováno v:
Human Genetics
Congenital diarrheal disorders (CDD) comprise > 50 monogenic entities featuring chronic diarrhea of early-onset, including defects in nutrient and electrolyte absorption, enterocyte polarization, enteroendocrine cell differentiation, and epithelial i
Publikováno v:
Mol Immunol
The human hs1.2 enhancer within the Ig heavy chain gene (IGH) is polymorphic and associated with a number of autoimmune diseases. The polymorphic region is characterized by tandem repeats of an ∼53-bp invariant sequence containing possible binding
Autor:
Hendrik Milting, Hans Ebbinghaus, Marcus-André Deutsch, Brenda Gerull, Jens Tiesmeier, Andreas Peterschröder, Caroline Stanasiuk, Anna Gärtner, Jan Gummert, Henrik Fox, Bärbel Klauke, Thorsten Laser, Lech Paluszkiewicz, Jana Davina Debus, Jördis Bax, Jürgen Weiss, Andreas Brodehl
Publikováno v:
Journal of Molecular and Cellular Cardiology. 141:17-29
Aims We aimed to unravel the genetic, molecular and cellular pathomechanisms of DSC2 truncation variants leading to arrhythmogenic cardiomyopathy (ACM). Methods and results We report a homozygous 4-bp DSC2 deletion variant c.1913_1916delAGAA, p.Q638L
Publikováno v:
Applied Biochemistry and Biotechnology. 191:1638-1652
Microbes are often subjected to oxidative stress in nature that badly affects their growth rate and viability. Although the response of microbes against oxidative stress has been characterized at the chemical, physiological, and molecular levels, the
Autor:
Vanessa Schmidt, Isabel Faust, Doris Hendig, Joachim Kuhn, Jörg H W Distler, Bastian Fischer, Lara Riedel, Cornelius Knabbe, Thanh-Diep Ly
Publikováno v:
Biochemical and Biophysical Research Communications. 523:1001-1006
Remodelling of the extracellular matrix by myofibroblasts is crucial for wound repair, but if deregulated, it might contribute to the development of fibrosis. Fibroblast-to-myofibroblast differentiation is promoted by aberrant microRNA-145-5p (miR-14
Autor:
Xiaolin Wei, Xiaowu Li, Wenjing Zheng, Yong He, Minjie Peng, Peikai Tian, Xiangde Liu, Hui Liu
Publikováno v:
Cell Cycle
Circular RNAs (circRNAs) are new types of endogenous non-coding RNAs, which are identified to have critical regulatory roles in cancer biology. In this study, we aimed to find the abnormally expressed circRNAs in hepatocellular carcinoma (HCC) and in
Publikováno v:
Biochemical and Biophysical Research Communications. 524:190-197
Dishevelled-associated antagonist of beta-catenin 2 (Dact2) is involved in the regulation of intracellular signaling pathways during development. It negatively regulates the Nodal signaling pathway, possibly by promoting lysosomal degradation of Noda