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Autor:
Zhensong Jiang, Jianru Zhang
Publikováno v:
Cell Cycle
EXs (Exosomes) secreted by mesenchymal stem cells (MSCs) have the potential to treat spinal cord injury (SCI), this study aimed to further explore the therapeutic effect of EXs on SCI. Firstly, EXs were extracted from MSCs and analyzed with a transmi
Autor:
Yanjie Zhang, Yange Zhang, Yang Bin, Qin Miao, Yajun Sun, Li Lin, Qi Wang, Li Yanzhong, Ruiling Zhang
Publikováno v:
Biochemical and Biophysical Research Communications. 541:90-94
Chronic and excessive alcohol consumption leads to alcoholic liver disease (ALD). However, the molecular mechanisms in the regulation of ALD have not been fully deciphered. Liver lipid accumulation is an important research direction in ALD. In this s
Autor:
Gong Min, Xing Feng, Bin Sun, Lan-Lan Tan, Hong Li, Ning Sha, Po Miao, Qiuyan Tian, Xiaofeng Yang, Yuan-Yuan Yang, Jian Yu, Li-Xiao Xu, Chen-Xi Feng, Mei Li, Xin Ding
Publikováno v:
Biochemical and Biophysical Research Communications. 528:1-6
A common, yet often neglectable, feature of neonatal hypoxic-ischemic brain damage (HIBD) is circadian rhythm disorders resulted from pineal gland dysfunction. Our previous work demonstrated that miRNAs play an important role in regulating key circad
Publikováno v:
RNA Biol
The detailed pathogenesis of endometriosis remains largely unclear despite decades of research. Recent studies have demonstrated that miRNAs plays an important role in endometriosis. The expression of miR-142-3p was decreased in ectopic endometrial t
Autor:
Yiyun Geng, Xiaodong Chen, Xiaoying Zhao, Sai-Chuen Fu, Yung Shu-Huang Patrick, Xiaoling Zhang, Jiajia Xu, Guoli Hu, Xudong Zhang, Kerong Dai
Publikováno v:
Journal of Molecular Cell Biology
Tendinopathy, which is characterized by the ectopic ossification of tendon, is a common disease occurring in certain population, such as athletes that suffer from repetitive tendon strains. However, the molecular mechanism underlying the pathogenesis
Autor:
Takayoshi Kiba
Publikováno v:
Pancreas. 49(6)
Publikováno v:
Cell Cycle
The present study was designed to investigate whether and how lncRNA-GAS5 regulates cardiomyocyte apoptosis in MI. MI rat model was established by the left anterior descending (LAD) coronary artery ligation. MI model was further evaluated by biomarke
Autor:
Renata Peterkova, Zsuzsanna Izsvák, Vladimír Landa, Vladimír Křen, Miroslava Šimáková, Michal Pravenec, Colby G. Starker, Daniel F. Voytas, František Liška, Jan Šilhavý, Petr Mlejnek, Miroslav Peterka, Vaclav Zidek
Publikováno v:
PLoS ONE
PLoS ONE, Vol 15, Iss 1, p e0228139 (2020)
PLoS ONE, Vol 15, Iss 1, p e0228139 (2020)
Recently, it has been found that spontaneous mutation Lx (polydactyly-luxate syndrome) in the rat is determined by deletion of a conserved intronic sequence of the Plzf (Promyelocytic leukemia zinc finger protein) gene. In addition, Plzf is a promine
Autor:
Fu-Chan Wei, Chih-Fan Lin, Ling-Yi Shih, Cheng-Hung Lin, Nidal F. Al Deek, Hui-Yun Cheng, Xiao-Ting Huang
Publikováno v:
Journal of Immunology Research, Vol 2020 (2020)
Journal of Immunology Research
Journal of Immunology Research
Chimerism has been associated with the induction and maintenance of tolerance to vascularized composite allotransplants (VCA). Although most VCA studies have examined chimerism using flow cytometry, we proposed that precision in the measurement of ch
Publikováno v:
Journal of Investigative Medicine. 66:39-45
To investigate the role of miRNA-15b in cardiomyocyte apoptosis after ischemia reperfusion injury in acute myocardial infarction (AMI), we conducted the AMI rat model by using left anterior descending ligation and performed hypoxia/reoxygenation expe