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Autor:
Jiarui Wang, Xianqin Zhang, Tingting Zou, Dazhi Zhang, Wenqiang Liu, Zhenxing Liu, Xuejie Peng, Zhengyi Ni, Yang Tan, Meiqi Hou, Mi Zhou, Chao Yuan, Xiaopei Zhou
Publikováno v:
Biochemical and Biophysical Research Communications. 591:124-129
Mendelian susceptibility to mycobacterial disease (MSMD) is a rare monogenetic disease, which is characterized by susceptibility to some weakly virulent mycobacteria. Here, we explored the pathogenic genes and molecular mechanisms of MSMD patients. W
Autor:
Takatoshi Hikida, Hiroshi Shiraishi, Minoru Fujiki, Takashi Kobayashi, Hiroyuki Fujinami, Ikuko Morisaki, Josef M. Penninger, Toshikatsu Hanada, Reiko Hanada, Nobuyuki Shimizu, Yuji Arai
Publikováno v:
Biochemical and Biophysical Research Communications. 570:60-66
Cleavage factor polyribonucleotide kinase subunit 1 (CLP1), an RNA kinase, plays essential roles in protein complexes involved in the 3'-end formation and polyadenylation of mRNA and the tRNA splicing endonuclease complex, which is involved in precur
Autor:
Goran Kokic, Patrick Cramer, Claudia Höbartner, Jana Schmitzová, Hauke S. Hillen, Carina Stiller, Christian Dienemann, Florian Kabinger
Publikováno v:
Nature Structural & Molecular Biology
Signal Transduction and Targeted Therapy
Nature Structural and Molecular Biology
Signal Transduction and Targeted Therapy
Nature Structural and Molecular Biology
Molnupiravir is an orally available antiviral drug candidate currently in phase III trials for the treatment of patients with COVID-19. Molnupiravir increases the frequency of viral RNA mutations and impairs SARS-CoV-2 replication in animal models an
Autor:
Yuntao Liu, Chun Zhang, Hua Su, Yaling Shi, Hongchun Lin, Xinxin Ma, Hui Peng, Zhongde Zhang, Lan Song, Fang Xiao
Publikováno v:
The Febs Journal
The kidney tropism of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) has been well‐validated clinically and often leads to various forms of renal damage in coronavirus disease‐2019 (COVID‐19) patients. However, the underlying
Autor:
Marcel I. Ramirez, Silvio Sanches Veiga, Elidiana De-Bona, Zelinda Schemczssen-Graeff, Izadora Volpato Rossi, Antonielle Beatriz Baldissera, Jenifer Nowatzki, Andrea Senff-Ribeiro, João Carlos Minozzo, Luiza Helena Gremski, Nayanne Louise Costacurta Polli, Fernando Hitomi Matsubara, Hanna Câmara da Justa
Publikováno v:
International Journal of Biological Macromolecules. 183:1607-1620
Several classes of toxins are present in the venom of Brown spiders (Loxosceles genus), some of them are highly expressed and others are less expressed. In this work, we aimed to clone the sequence of a little expressed novel toxin from Loxosceles ve
Autor:
Jiqun Geng, Kaihua Yang
Publikováno v:
DNA and Cell Biology. 40:675-682
Circular RNAs have been shown to regulate cancer tumorigenesis and drug resistance. Recently, circCCND1 is reported to promote laryngeal squamous cell carcinoma; however, whether circCCND1 is implicated in non-small cell lung cancer (NSCLC) remains u
Publikováno v:
Biochemical and Biophysical Research Communications. 548:174-181
Background Sepsis is a serious and elusive syndrome caused by infection, with high mortality worldwide. Circular RNAs vacuolar ATPase assembly factor (circVMA21) has been reported to be related to the inflammatory damages in sepsis. This study is des
Publikováno v:
Biochemical and Biophysical Research Communications. 548:112-119
Long noncoding RNAs (lncRNAs) have been identified as functional modulators in human tumors. The purpose of our study was to determine the expressing trend, clinical significance and functions of lncRNA LINC02381(LINC02381) in osteosarcoma. We observ
Autor:
Liangxue Lai, Jinfu Lin, Shixue Gou, Xiaoping Li, Yaqin Li, Hui Shi, Cheng Zhang, Anding Xu, Lei Li, Liang Wang, Huan Li, Wenjing Guo, Xiaoyu Yang, Xiaomin Wang, Qin Jin, Zhiwu Jiang, Menglong Chen, Huili Zhang, Yuling Zhu, Han Wu
Publikováno v:
Genome Medicine, Vol 13, Iss 1, Pp 1-19 (2021)
Genome Medicine
Genome Medicine
Background Mutations in the DMD gene encoding dystrophin—a critical structural element in muscle cells—cause Duchenne muscular dystrophy (DMD), which is the most common fatal genetic disease. Clustered regularly interspaced short palindromic repe
Publikováno v:
Molecular Biology Reports. 48:2223-2233
TEOSINTE BRANCHED 1/CYCLOIDEA/PROLIFERATING CELL FACTOR 1 (TCP) transcription factors control multiple aspects of growth and development in various plant species. However, few genes were reported to be directly targeted and regulated by them through