Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Tobias L. Lenz"'
Autor:
Onur Özer, Tobias L. Lenz
Publikováno v:
Molecular Biology and Evolution
A key component of pathogen-specific adaptive immunity in vertebrates is the presentation of pathogen-derived antigenic peptides by major histocompatibility complex (MHC) molecules. The excessive polymorphism observed at MHC genes is widely presumed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f191819f5184ae3c3aeab5c93353873d
https://hdl.handle.net/21.11116/0000-000A-17DF-221.11116/0000-000A-17E1-E
https://hdl.handle.net/21.11116/0000-000A-17DF-221.11116/0000-000A-17E1-E
Autor:
Mary Carrington, Tobias L. Lenz, Federica Pierini, Jacques Fellay, Paul J. McLaren, Jatin Arora
Publikováno v:
Molecular biology and evolution, vol. 37, no. 3, pp. 639-650
Molecular Biology and Evolution
Molecular Biology and Evolution
Pathogen-mediated balancing selection is regarded as a key driver of host immunogenetic diversity. A hallmark for balancing selection in humans is the heterozygote advantage at genes of the human leukocyte antigen (HLA), resulting in improved HIV-1 c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::996687938bd13cc63fdb99d363b53a5f
https://serval.unil.ch/resource/serval:BIB_4A4E20C0A676.P001/REF.pdf
https://serval.unil.ch/resource/serval:BIB_4A4E20C0A676.P001/REF.pdf
Publikováno v:
Radwan, J, Babik, W, Kaufman, J, Lenz, T L & Winternitz, J 2020, ' Advances in the evolutionary understanding of MHC polymorphism ', Trends in Genetics, vol. 36, no. 4, pp. 298-311 . https://doi.org/10.1016/j.tig.2020.01.008
Trends in Genetics
Trends in Genetics
Proteins encoded by the classical major histocompatibility complex (MHC) genes incite the vertebrate adaptive immune response by presenting peptide antigens on the cell surface. Here, we review mechanisms explaining landmark features of these genes:
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::323bd5041e3338b2a43cfe7ff65e01ab
https://www.pure.ed.ac.uk/ws/files/139132969/1_s2.0_S0168952520300214_main.pdf
https://www.pure.ed.ac.uk/ws/files/139132969/1_s2.0_S0168952520300214_main.pdf
Autor:
Tobias L. Lenz, Federica Pierini
Publikováno v:
Molecular Biology and Evolution
The highly polymorphic genes of the major histocompatibility complex (MHC) play a key role in adaptive immunity. Divergent allele advantage, a mechanism of balancing selection, is proposed to contribute to their exceptional polymorphism. It assumes t
Publikováno v:
Molecular Biology and Evolution
Deleterious mutations are expected to evolve under negative selection and are usually purged from the population. However, deleterious alleles segregate in the human population and some disease-associated variants are maintained at considerable frequ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f630e31e1ae7f0dff4084328be2657a7
https://hdl.handle.net/11858/00-001M-0000-002B-58FC-411858/00-001M-0000-002B-58FE-F
https://hdl.handle.net/11858/00-001M-0000-002B-58FC-411858/00-001M-0000-002B-58FE-F
Publikováno v:
Evolution. 67:2400-2412
The immunologically important major histocompatibility complex (MHC) harbors some of the most polymorphic genes in vertebrates. These genes presumably evolve under parasite-mediated selection and frequently show inconsistent allelic genealogies, wher
Autor:
Tobias L. Lenz
Publikováno v:
Evolution. 65:2380-2390
The major histocompatibility complex (MHC), coding for antigen presenting molecules of the adaptive immune system, represents one of the most polymorphic regions in the vertebrate genome. The exceptional polymorphism, which is potentially maintained
Publikováno v:
Nature Communications
Nature Communications, 3 . p. 621.
Nature Communications, 3 . p. 621.
The genes of the major histocompatibility complex are the most polymorphic genes in vertebrates, with more than 1,000 alleles described in human populations. How this polymorphism is maintained, however, remains an evolutionary puzzle. Major histocom
Publikováno v:
Proceedings of the Royal Society B: Biological Sciences. 280:20130714
It is still debated whether main individual fitness differences in natural populations can be attributed to genome-wide effects or to particular loci of outstanding functional importance such as the major histocompatibility complex (MHC). In a long-t