Zobrazeno 1 - 6
of 6
pro vyhledávání: '"David Flyer"'
Autor:
Bin Zhou, Larry Elllingsworth, Ye Liu, Gregory M. Glenn, Jing-Hui Tian, David Flyer, Gale Smith, Eddie Sullivan, Hua Wu, James F. Cummings
Publikováno v:
Vaccine. 35:4079-4087
Clostridium difficile is the number one cause of nosocomial antibiotic-associated diarrhea in developed countries. Historically, pathogenesis was attributed two homologous glucosylating toxins, toxin-A (TcdA) and toxin-B (TcdB). Over the past decade,
Autor:
Irina Petrushina, David H. Cribbs, Hayk Davtyan, Lars Østergaard Pedersen, Anahit Ghochikyan, David Flyer, Jianmei Yu, Peter Juul Madsen, Michael G. Agadjanyan, Armine Hovakimyan
Publikováno v:
Journal of Neuroimmunology. 268:50-57
Immunotherapeutic approaches to treating Alzheimer's disease (AD) using vaccination strategies must overcome the obstacle of achieving adequate responses to vaccination in the elderly. Here we demonstrate for the first time that application of the Es
Autor:
Steven R. Fuhrmann, Larry Ellingsworth, Stefanie Kluepfel-Stahl, Robert J. Carman, Jing-Hui Tian, David Flyer
Publikováno v:
Vaccine. 30:4249-4258
Antibodies targeting the Clostridium difficile toxin A and toxin B confer protective immunity to C. difficile associated disease in animal models and provided protection against recurrent C. difficile disease in human subjects. These antibodies are d
Autor:
Gregory M. Glenn, Robin McKenzie, Christina P. Villar, Sarah A. Frech, A. Louis Bourgeois, Robert M. Lavker, David Flyer
Publikováno v:
Infection and Immunity. 75:2163-2170
Transcutaneous immunization allows safe delivery of native heat-labile enterotoxin (LT) from Escherichia coli via application of a simple patch. Physical disruption of the stratum corneum can improve the efficiency of delivery. In the current study,
Transcutaneous immunization with heat-labile enterotoxin: development of a needle-free vaccine patch
Autor:
Larry Ellingsworth, Gregory M. Glenn, Jianmei Yu, David Flyer, David Frerichs, Sarah A. Frech, Robert C. Seid
Publikováno v:
Expert review of vaccines. 6(5)
The skin is an attractive target for vaccine delivery. Adjuvants and antigens delivered into the skin can result in potent immune responses and an unmatched safety profile. The heat-labile enterotoxin (LT) from Escherichia coli, which acts both as an
Autor:
Kazem Kazempour, David Flyer, A. Louis Bourgeois, Gregory M. Glenn, Sarah A. Frech, Robin McKenzie, Arlene Bloom
Publikováno v:
Vaccine. 25(18)
Background An enterotoxigenic Escherichia coli (ETEC) vaccine could reduce diarrhea among children in developing countries and travelers to these countries. The heat-labile toxin (LT) of ETEC is immunogenic but too toxic for oral or nasal vaccines. M